An antiviral trap made of protein nanofibrils and iron oxyhydroxide nanoparticles.
Journal
Nature nanotechnology
ISSN: 1748-3395
Titre abrégé: Nat Nanotechnol
Pays: England
ID NLM: 101283273
Informations de publication
Date de publication:
08 2021
08 2021
Historique:
received:
22
01
2021
accepted:
27
04
2021
pubmed:
5
6
2021
medline:
28
8
2021
entrez:
4
6
2021
Statut:
ppublish
Résumé
Minimizing the spread of viruses in the environment is the first defence line when fighting outbreaks and pandemics, but the current COVID-19 pandemic demonstrates how difficult this is on a global scale, particularly in a sustainable and environmentally friendly way. Here we introduce and develop a sustainable and biodegradable antiviral filtration membrane composed of amyloid nanofibrils made from food-grade milk proteins and iron oxyhydroxide nanoparticles synthesized in situ from iron salts by simple pH tuning. Thus, all the membrane components are made of environmentally friendly, non-toxic and widely available materials. The membrane has outstanding efficacy against a broad range of viruses, which include enveloped, non-enveloped, airborne and waterborne viruses, such as SARS-CoV-2, H1N1 (the influenza A virus strain responsible for the swine flu pandemic in 2009) and enterovirus 71 (a non-enveloped virus resistant to harsh conditions, such as highly acidic pH), which highlights a possible role in fighting the current and future viral outbreaks and pandemics.
Identifiants
pubmed: 34083772
doi: 10.1038/s41565-021-00920-5
pii: 10.1038/s41565-021-00920-5
doi:
Substances chimiques
Amyloid
0
Antiviral Agents
0
Ferric Compounds
0
Lactoglobulins
0
ferric hydroxide
2UA751211N
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
918-925Informations de copyright
© 2021. The Author(s), under exclusive licence to Springer Nature Limited.
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