Canonical Secretomes, Innate Immune Caspase-1-, 4/11-Gasdermin D Non-Canonical Secretomes and Exosomes May Contribute to Maintain Treg-Ness for Treg Immunosuppression, Tissue Repair and Modulate Anti-Tumor Immunity

Animals Biomarkers Caspases / metabolism Computational Biology / methods Disease Susceptibility Exosomes / metabolism Gene Expression Profiling Gene Expression Regulation, Enzymologic Gene Expression Regulation, Neoplastic Humans Immunity, Innate Mice Models, Biological Neoplasms / genetics Organ Specificity / immunology Reactive Oxygen Species / metabolism Signal Transduction T-Lymphocytes, Regulatory / immunology
CD4+Foxp3+ regulatory T cells (Treg) canonical secretome immune checkpoint receptors innate immune caspase-1 dependent secretome innate immune caspase-4/11 dependent secretome

Journal

Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960

Informations de publication

Date de publication:
2021
Historique:
received: 09 03 2021
accepted: 01 04 2021
entrez: 4 6 2021
pubmed: 5 6 2021
medline: 27 10 2021
Statut: epublish

Résumé

We performed a transcriptomic analyses using the strategies we pioneered and made the following findings:

Identifiants

DOI: 10.3389/fimmu.2021.678201 PMID: 34084175 PMC: PMC8168470
pubmed: 34084175
doi: 10.3389/fimmu.2021.678201
pmc: PMC8168470
doi:

Substances chimiques

Biomarkers 0
Reactive Oxygen Species 0
Caspases EC 3.4.22.-

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

678201

Subventions

Organisme : NIAID NIH HHS
ID : R01 AI145034
Pays : United States

Informations de copyright

Copyright © 2021 Ni, Tang, Lu, Xu, Shao, Saaoud, Saredy, Liu, Drummer, Sun, Hu, Lopez-Pastrana, Luo, Jiang, Choi, Wang and Yang.

Déclaration de conflit d'intérêts

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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Auteurs

Dong Ni (D)

Centers for Cardiovascular Research, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, United States.

TingTing Tang (T)

Metabolic Disease Research & Thrombosis Research, Department of Cardiovascular Sciences, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, United States.

Yifan Lu (Y)

Centers for Cardiovascular Research, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, United States.

Keman Xu (K)

Centers for Cardiovascular Research, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, United States.

Ying Shao (Y)

Centers for Cardiovascular Research, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, United States.

Fatma Saaoud (F)

Centers for Cardiovascular Research, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, United States.

Jason Saredy (J)

Metabolic Disease Research & Thrombosis Research, Department of Cardiovascular Sciences, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, United States.

Lu Liu (L)

Metabolic Disease Research & Thrombosis Research, Department of Cardiovascular Sciences, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, United States.

Charles Drummer (C)

Centers for Cardiovascular Research, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, United States.

Yu Sun (Y)

Centers for Cardiovascular Research, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, United States.

Wenhui Hu (W)

Metabolic Disease Research & Thrombosis Research, Department of Cardiovascular Sciences, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, United States.

Jahaira Lopez-Pastrana (J)

Department of Psychiatry, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, United States.

Jin J Luo (JJ)

Department of Neurology, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, United States.

Xiaohua Jiang (X)

Centers for Cardiovascular Research, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, United States.
Metabolic Disease Research & Thrombosis Research, Department of Cardiovascular Sciences, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, United States.

Eric T Choi (ET)

Division of Vascular and Endovascular Surgery, Department of Surgery, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, United States.

Hong Wang (H)

Metabolic Disease Research & Thrombosis Research, Department of Cardiovascular Sciences, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, United States.

Xiaofeng Yang (X)

Centers for Cardiovascular Research, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, United States.
Metabolic Disease Research & Thrombosis Research, Department of Cardiovascular Sciences, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, United States.
Inflammation, Translational & Clinical Lung Research, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, United States.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Canonical Secretomes, Innate Immune...
questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › Canonical Secretomes, Innate Immune...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protéines régulatrices de l'apoptose › Caspases › Canonical Secretomes, Innate Immune...
questionsmedicales.fr › Sciences de l'information › Informatique › Biologie informatique › Canonical Secretomes, Innate Immune...
questionsmedicales.fr › Phénomènes physiologiques › Constitution physique › Prédisposition aux maladies › Canonical Secretomes, Innate Immune...
questionsmedicales.fr › Cellules › Structures cellulaires › Espace intracellulaire › Cytoplasme › Structures cytoplasmiques › Organites › Vésicules cytoplasmiques › Vésicules de transport › Exosomes › Canonical Secretomes, Innate Immune...
questionsmedicales.fr › Techniques d'investigation › Techniques génétiques › Analyse de profil d'expression de gènes › Canonical Secretomes, Innate Immune...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Régulation de l'expression des gènes codant pour des enzymes › Canonical Secretomes, Innate Immune...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Régulation de l'expression des gènes tumoraux › Canonical Secretomes, Innate Immune...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Canonical Secretomes, Innate Immune...
questionsmedicales.fr › Phénomènes du système immunitaire › Immunité › Immunité innée › Canonical Secretomes, Innate Immune...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Canonical Secretomes, Innate Immune...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Canonical Secretomes, Innate Immune...
questionsmedicales.fr › Tumeurs › Canonical Secretomes, Innate Immune...
questionsmedicales.fr › Phénomènes physiologiques › Spécificité d'organe › Canonical Secretomes, Innate Immune...
questionsmedicales.fr › Produits chimiques inorganiques › Composés de l'oxygène › Espèces réactives de l'oxygène › Canonical Secretomes, Innate Immune...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › Canonical Secretomes, Innate Immune...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Sous-populations de lymphocytes T › Lymphocytes T régulateurs › Canonical Secretomes, Innate Immune...