Fatma Saaoud

Affiliations

Cardiovascular Research Center, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, United States.

Publications (36)

A Novel Subset of CD95

Frontiers in immunology

Avec: Candice Johnson , Charles Drummer Iv , Huimin Shan , Ying Shao , Yu Sun , Yifan Lu , Fatma Saaoud , Keman Xu , Gayani Nanayakkara , Pu Fang , Zsolt Bagi , Xiaohua Jiang , Eric T Choi , Hong Wang , Xiaofeng Yang

Caspase-4/11 promotes hyperlipidemia and chronic kidney disease-accelerated vascular inflammation by enhancing trained immunity.

JCI insight

Avec: Yu Sun , Yifan Lu , Lu Liu , Fatma Saaoud , Ying Shao , Keman Xu , Charles Drummer Iv , Ramon Cueto , Huimin Shan , Xiaohua Jiang , Huaqing Zhao , Hong Wang , Xiaofeng Yang

Chronic Kidney Disease Transdifferentiates Veins into a Specialized Immune-Endocrine Organ with Increased MYCN-AP1 Signaling.

Cells

Avec: Fatma Saaoud , Laisel Martinez , Yifan Lu , Keman Xu , Ying Shao , Jia L Zhuo , Avrum Gillespie , Hong Wang , Marwan Tabbara , Alghidak Salama , Xiaofeng Yang , Roberto I Vazquez-Padron

A new paradigm in intracellular immunology: Mitochondria emerging as leading immune organelles.

Redox biology

Avec: Keman Xu , Fatma Saaoud , Ying Shao , Yifan Lu , Qiaoxi Yang , Xiaohua Jiang , Hong Wang , Xiaofeng Yang

Increased acetylation of H3K14 in the genomic regions that encode trained immunity enzymes in lysophosphatidylcholine-activated human aortic endothelial cells - Novel qualification markers for chronic disease risk factors and conditional DAMPs.

Redox biology

Avec: Yifan Lu , Yu Sun , Charles Drummer , Gayani K Nanayakkara , Ying Shao , Fatma Saaoud , Candice Johnson , Ruijing Zhang , Daohai Yu , Xinyuan Li , William Y Yang , Jun Yu , Xiaohua Jiang , Eric T Choi , Hong Wang , Xiaofeng Yang

Twenty Novel Disease Group-Specific and 12 New Shared Macrophage Pathways in Eight Groups of 34 Diseases Including 24 Inflammatory Organ Diseases and 10 Types of Tumors.

Frontiers in immunology

Avec: Bin Lai , Jiwei Wang , Alexander Fagenson , Yu Sun , Jason Saredy , Yifan Lu , Gayani Nanayakkara , William Y Yang , Daohai Yu , Ying Shao , Charles Drummer , Candice Johnson , Fatma Saaoud , Ruijing Zhang , Qian Yang , Keman Xu , Kevin Mastascusa , Ramon Cueto , Hangfei Fu , Susu Wu , Lizhe Sun , Peiqian Zhu , Xuebin Qin , Jun Yu , Daping Fan , Ying H Shen , Jianxin Sun , Thomas Rogers , Eric T Choi , Hong Wang , Xiaofeng Yang

IL-35 promotes CD4+Foxp3+ Tregs and inhibits atherosclerosis via maintaining CCR5-amplified Treg-suppressive mechanisms.

JCI insight

Avec: Ying Shao , William Y Yang , Fatma Saaoud , Charles Drummer , Yu Sun , Keman Xu , Yifan Lu , Huimin Shan , Ethan M Shevach , Xiaohua Jiang , Hong Wang , Xiaofeng Yang

Canonical Secretomes, Innate Immune Caspase-1-, 4/11-Gasdermin D Non-Canonical Secretomes and Exosomes May Contribute to Maintain Treg-Ness for Treg Immunosuppression, Tissue Repair and Modulate Anti-Tumor Immunity

Frontiers in immunology

Avec: Dong Ni , TingTing Tang , Yifan Lu , Keman Xu , Ying Shao , Fatma Saaoud , Jason Saredy , Lu Liu , Charles Drummer , Yu Sun , Wenhui Hu , Jahaira Lopez-Pastrana , Jin J Luo , Xiaohua Jiang , Eric T Choi , Hong Wang , Xiaofeng Yang

Early hyperlipidemia triggers metabolomic reprogramming with increased SAH, increased acetyl-CoA-cholesterol synthesis, and decreased glycolysis.

Redox biology

Avec: Keman Xu , Fatma Saaoud , Ying Shao , Yifan Lu , Sheng Wu , Huaqing Zhao , Kaifu Chen , Roberto Vazquez-Padron , Xiaohua Jiang , Hong Wang , Xiaofeng Yang

End-stage renal disease is different from chronic kidney disease in upregulating ROS-modulated proinflammatory secretome in PBMCs - A novel multiple-hit model for disease progression.

Redox biology

Avec: Ruijing Zhang , Jason Saredy , Ying Shao , Tian Yao , Lu Liu , Fatma Saaoud , William Y Yang , Yu Sun , Candice Johnson , Charles Drummer , Hangfei Fu , Yifan Lu , Keman Xu , Ming Liu , Jirong Wang , Elizabeth Cutler , Daohai Yu , Xiaohua Jiang , Yafeng Li , Rongshan Li , Lihua Wang , Eric T Choi , Hong Wang , Xiaofeng Yang

ROS systems are a new integrated network for sensing homeostasis and alarming stresses in organelle metabolic processes.

Redox biology

Avec: Yu Sun , Yifan Lu , Jason Saredy , Xianwei Wang , Charles Drummer Iv , Ying Shao , Fatma Saaoud , Keman Xu , Ming Liu , William Y Yang , Xiaohua Jiang , Hong Wang , Xiaofeng Yang

Approaching Inflammation Paradoxes-Proinflammatory Cytokine Blockages Induce Inflammatory Regulators.

Frontiers in immunology

Avec: Ming Liu , Jason Saredy , Ruijing Zhang , Ying Shao , Yu Sun , William Y Yang , Jirong Wang , Lu Liu , Charles Drummer , Candice Johnson , Fatma Saaoud , Yifan Lu , Keman Xu , Li Li , Xin Wang , Xiaohua Jiang , Hong Wang , Xiaofeng Yang

Procaspase-1 patrolled to the nucleus of proatherogenic lipid LPC-activated human aortic endothelial cells induces ROS promoter CYP1B1 and strong inflammation.

Redox biology

Avec: Yifan Lu , Gayani Nanayakkara , Yu Sun , Lu Liu , Keman Xu , Charles Drummer , Ying Shao , Fatma Saaoud , Eric T Choi , Xiaohua Jiang , Hong Wang , Xiaofeng Yang

Monocyte Adhesion Assays for Detecting Endothelial Cell Activation in Vascular Inflammation and Atherosclerosis.

Methods in molecular biology (Clifton, N.J.)

Avec: Keman Xu , Fatma Saaoud , Stephanie Yu , Charles Drummer , Ying Shao , Yu Sun , Yifan Lu , Jianxin Sun , Jun Yu , Xiaohua Jiang , Hong Wang , Xiaofeng Yang

Aorta- and liver-generated TMAO enhances trained immunity for increased inflammation via ER stress/mitochondrial ROS/glycolysis pathways.

JCI insight

Avec: Fatma Saaoud , Lu Liu , Keman Xu , Ramon Cueto , Ying Shao , Yifan Lu , Yu Sun , Nathaniel W Snyder , Sheng Wu , Ling Yang , Yan Zhou , David L Williams , Chuanfu Li , Laisel Martinez , Roberto I Vazquez-Padron , Huaqing Zhao , Xiaohua Jiang , Hong Wang , Xiaofeng Yang

The Microbial Metabolite Trimethylamine N-Oxide Links Vascular Dysfunctions and the Autoimmune Disease Rheumatoid Arthritis.

Nutrients

Avec: Marion M Chan , Xiaofeng Yang , Hong Wang , Fatma Saaoud , Yu Sun , Dunne Fong

Bone marrow deficiency of mRNA decaying protein Tristetraprolin increases inflammation and mitochondrial ROS but reduces hepatic lipoprotein production in LDLR knockout mice.

Redox biology

Avec: Fatma Saaoud , Junfeng Wang , Stephen Iwanowycz , Yuzhen Wang , Diego Altomare , Ying Shao , Jianguo Liu , Perry J Blackshear , Susan M Lessner , E Angela Murphy , Hong Wang , Xiaofeng Yang , Daping Fan

Overexpression of microRNA-155 enhances the efficacy of dendritic cell vaccine against breast cancer.

Oncoimmunology

Avec: Johnie Hodge , Fang Wang , Junfeng Wang , Qing Liu , Fatma Saaoud , Yuzhen Wang , Udai P Singh , Hexin Chen , Ming Luo , Walden Ai , Daping Fan

Novel Knowledge-Based Transcriptomic Profiling of Lipid Lysophosphatidylinositol-Induced Endothelial Cell Activation.

Frontiers in cardiovascular medicine

Avec: Keman Xu , Ying Shao , Fatma Saaoud , Aria Gillespie , Charles Drummer , Lu Liu , Yifan Lu , Yu Sun , Hang Xi , Çagla Tükel , Domenico Pratico , Xuebin Qin , Jianxin Sun , Eric T Choi , Xiaohua Jiang , Hong Wang , Xiaofeng Yang

Liver Ischemia Reperfusion Injury, Enhanced by Trained Immunity, Is Attenuated in Caspase 1/Caspase 11 Double Gene Knockout Mice.

Pathogens (Basel, Switzerland)

Avec: Alexander M Fagenson , Keman Xu , Fatma Saaoud , Gayani Nanayakkara , Nirag C Jhala , Lu Liu , Charles Drummer , Yu Sun , Kwan N Lau , Antonio Di Carlo , Xiaohua Jiang , Hong Wang , Sunil S Karhadkar , Xiaofeng Yang

Ultrasound May Suppress Tumor Growth, Inhibit Inflammation, and Establish Tolerogenesis by Remodeling Innatome via Pathways of ROS, Immune Checkpoints, Cytokines, and Trained Immunity/Tolerance.

Journal of immunology research

Avec: Qian Yang , Ruijing Zhang , Peng Tang , Yu Sun , Candice Johnson , Jason Saredy , Susu Wu , Jiwei Wang , Yifan Lu , Fatma Saaoud , Ying Shao , Charles Drummer , Keman Xu , Daohai Yu , Rongshan Li , Shuping Ge , Xiaohua Jiang , Hong Wang , Xiaofeng Yang

29 m

Journal of immunology research

Avec: Ming Liu , Keman Xu , Fatma Saaoud , Ying Shao , Ruijing Zhang , Yifan Lu , Yu Sun , Charles Drummer , Li Li , Sheng Wu , Satya P Kunapuli , Gerard J Criner , Jianxin Sun , Huimin Shan , Xiaohua Jiang , Hong Wang , Xiaofeng Yang

Protein-rich foods, sea foods, and gut microbiota amplify immune responses in chronic diseases and cancers - Targeting PERK as a novel therapeutic strategy for chronic inflammatory diseases, neurodegenerative disorders, and cancer.

Pharmacology & therapeutics

Avec: Fatma Saaoud , Yifan Lu , Keman Xu , Ying Shao , Domenico Praticò , Roberto I Vazquez-Padron , Hong Wang , Xiaofeng Yang

Vascular Endothelial Cells and Innate Immunity.

Arteriosclerosis, thrombosis, and vascular biology

Avec: Ying Shao , Jason Saredy , William Y Yang , Yu Sun , Yifan Lu , Fatma Saaoud , Charles Drummer , Candice Johnson , Keman Xu , Xiaohua Jiang , Hong Wang , Xiaofeng Yang

Tissue Treg Secretomes and Transcription Factors Shared With Stem Cells Contribute to a Treg Niche to Maintain Treg-Ness With 80% Innate Immune Pathways, and Functions of Immunosuppression and Tissue Repair.

Frontiers in immunology

Avec: Ruijing Zhang , Keman Xu , Ying Shao , Yu Sun , Jason Saredy , Elizabeth Cutler , Tian Yao , Ming Liu , Lu Liu , Charles Drummer Iv , Yifan Lu , Fatma Saaoud , Dong Ni , Jirong Wang , Yafeng Li , Rongshan Li , Xiaohua Jiang , Hong Wang , Xiaofeng Yang

Circular RNAs are a novel type of non-coding RNAs in ROS regulation, cardiovascular metabolic inflammations and cancers.

Pharmacology & therapeutics

Avec: Fatma Saaoud , Charles Drummer I V , Ying Shao , Yu Sun , Yifan Lu , Keman Xu , Dong Ni , Xiaohua Jiang , Hong Wang , Xiaofeng Yang

MiR155 modulates vascular calcification by regulating Akt-FOXO3a signalling and apoptosis in vascular smooth muscle cells.

Journal of cellular and molecular medicine

Avec: Yong Li , Wei Sun , Fatma Saaoud , Yuzhen Wang , Quanyi Wang , Johnie Hodge , Yvonne Hui , Sophia Yin , Susan M Lessner , Xiangqing Kong , Daping Fan

Trained Immunity and Reactivity of Macrophages and Endothelial Cells.

Arteriosclerosis, thrombosis, and vascular biology

Avec: Charles Drummer , Fatma Saaoud , Ying Shao (邵颖) , Yu Sun (孙宇) , Keman Xu (徐克曼) , Yifan Lu (路一凡) , Dong Ni (倪栋) , Diana Atar , Xiaohua Jiang (蒋晓华) , Hong Wang (王虹) , Xiaofeng Yang

Hyperlipidemia May Synergize with Hypomethylation in Establishing Trained Immunity and Promoting Inflammation in NASH and NAFLD.

Journal of immunology research

Avec: Charles I V Drummer , Fatma Saaoud , Yu Sun , Diana Atar , Keman Xu , Yifan Lu , Ying Shao , Candice Johnson , Lu Liu , Huimin Shen , Nirag C Jhala , Xiaohua Jiang , Hong Wang , Xiaofeng Yang

Organelle Crosstalk Regulators Are Regulated in Diseases, Tumors, and Regulatory T Cells: Novel Classification of Organelle Crosstalk Regulators.

Frontiers in cardiovascular medicine

Avec: Ming Liu , Na Wu , Keman Xu , Fatma Saaoud , Eleni Vasilopoulos , Ying Shao , Ruijing Zhang , Jirong Wang , Haitao Shen , William Y Yang , Yifan Lu , Yu Sun , Charles Drummer , Lu Liu , Li Li , Wenhui Hu , Jun Yu , Domenico Praticò , Jianxin Sun , Xiaohua Jiang , Hong Wang , Xiaofeng Yang

Endothelial Immunity Trained by Coronavirus Infections, DAMP Stimulations and Regulated by Anti-Oxidant NRF2 May Contribute to Inflammations, Myelopoiesis, COVID-19 Cytokine Storms and Thromboembolism.

Frontiers in immunology

Avec: Ying Shao , Jason Saredy , Keman Xu , Yu Sun , Fatma Saaoud , Charles Drummer , Yifan Lu , Jin J Luo , Jahaira Lopez-Pastrana , Eric T Choi , Xiaohua Jiang , Hong Wang , Xiaofeng Yang

Aorta in Pathologies May Function as an Immune Organ by Upregulating Secretomes for Immune and Vascular Cell Activation, Differentiation and Trans-Differentiation-Early Secretomes may Serve as Drivers for Trained Immunity.

Frontiers in immunology

Avec: Yifan Lu , Yu Sun , Keman Xu , Fatma Saaoud , Ying Shao , Charles Drummer , Sheng Wu , Wenhui Hu , Jun Yu , Satya P Kunapuli , John R Bethea , Roberto I Vazquez-Padron , Jianxin Sun , Xiaohua Jiang , Hong Wang , Xiaofeng Yang

Cigarette Smoke and Morphine Promote Treg Plasticity to Th17 via Enhancing Trained Immunity.

Cells

Avec: Ying Shao , Fatma Saaoud , William Cornwell , Keman Xu , Aaron Kirchhoff , Yifan Lu , Xiaohua Jiang , Hong Wang , Thomas J Rogers , Xiaofeng Yang

Caspase-11 promotes high-fat diet-induced NAFLD by increasing glycolysis, OXPHOS, and pyroptosis in macrophages.

Frontiers in immunology

Avec: Charles Drummer , Fatma Saaoud , Nirag C Jhala , Ramon Cueto , Yu Sun , Keman Xu , Ying Shao , Yifan Lu , Huimin Shen , Ling Yang , Yan Zhou , Jun Yu , Sheng Wu , Nathaniel W Snyder , Wenhui Hu , Jia 'Joe' Zhuo , Yinghui Zhong , Xiaohua Jiang , Hong Wang , Xiaofeng Yang

ER stress mediates Angiotensin II-augmented innate immunity memory and facilitates distinct susceptibilities of thoracic from abdominal aorta to aneurysm development.

Frontiers in immunology

Avec: Yifan Lu , Yu Sun , Fatma Saaoud , Ying Shao , Keman Xu , Xiaohua Jiang , Sheng Wu , Jun Yu , Nathaniel W Snyder , Ling Yang , Xinghua Mindy Shi , Huaqing Zhao , Hong Wang , Xiaofeng Yang

Innate immunity of vascular smooth muscle cells contributes to two-wave inflammation in atherosclerosis, twin-peak inflammation in aortic aneurysms and trans-differentiation potential into 25 cell types.

Frontiers in immunology

Avec: Qiaoxi Yang , Fatma Saaoud , Yifan Lu , Yujiang Pu , Keman Xu , Ying Shao , Xiaohua Jiang , Sheng Wu , Ling Yang , Ying Tian , Xiaolei Liu , Avrum Gillespie , Jin Jun Luo , Xinghua Mindy Shi , Huaqing Zhao , Laisel Martinez , Roberto Vazquez-Padron , Hong Wang , Xiaofeng Yang

Réseau de co-auteurs

Xiaofeng Yang 34 collaborations

Hong Wang 33 collaborations

Ying Shao 31 collaborations

Yifan Lu 30 collaborations

Keman Xu 30 collaborations

Xiaohua Jiang 28 collaborations

Yu Sun 26 collaborations

Charles Drummer 18 collaborations

Lu Liu 11 collaborations

Jason Saredy 9 collaborations

Candice Johnson 8 collaborations

Eric T Choi 8 collaborations

Ruijing Zhang 8 collaborations

William Y Yang 8 collaborations

Jun Yu 7 collaborations

Sheng Wu 7 collaborations

Jianxin Sun 6 collaborations

Ming Liu 6 collaborations

Huaqing Zhao 5 collaborations

Charles Drummer Iv 4 collaborations

Huimin Shan 4 collaborations

Gayani Nanayakkara 4 collaborations

Ramon Cueto 4 collaborations

Roberto I Vazquez-Padron 4 collaborations

Daohai Yu 4 collaborations

Daping Fan 4 collaborations

Wenhui Hu 4 collaborations

Jirong Wang 4 collaborations

Ling Yang 4 collaborations

Laisel Martinez 3 collaborations

Dong Ni 3 collaborations

Rongshan Li 3 collaborations

Li Li 3 collaborations

Nathaniel W Snyder 3 collaborations

Yuzhen Wang 3 collaborations

Nirag C Jhala 3 collaborations

Avrum Gillespie 2 collaborations

Qiaoxi Yang 2 collaborations

Jiwei Wang 2 collaborations

Qian Yang 2 collaborations

Hangfei Fu 2 collaborations

Susu Wu 2 collaborations

Xuebin Qin 2 collaborations

Jahaira Lopez-Pastrana 2 collaborations

Jin J Luo 2 collaborations

Roberto Vazquez-Padron 2 collaborations

Tian Yao 2 collaborations

Elizabeth Cutler 2 collaborations

Yafeng Li 2 collaborations

Yan Zhou 2 collaborations

Junfeng Wang 2 collaborations

Susan M Lessner 2 collaborations

Johnie Hodge 2 collaborations

Satya P Kunapuli 2 collaborations

Domenico Praticò 2 collaborations

Diana Atar 2 collaborations

Huimin Shen 2 collaborations

Xinghua Mindy Shi 2 collaborations

Pu Fang 1 collaboration

Zsolt Bagi 1 collaboration

Jia L Zhuo 1 collaboration

Marwan Tabbara 1 collaboration

Alghidak Salama 1 collaboration

Gayani K Nanayakkara 1 collaboration

Xinyuan Li 1 collaboration

Bin Lai 1 collaboration

Alexander Fagenson 1 collaboration

Kevin Mastascusa 1 collaboration

Lizhe Sun 1 collaboration

Peiqian Zhu 1 collaboration

Ying H Shen 1 collaboration

Thomas Rogers 1 collaboration

Ethan M Shevach 1 collaboration

TingTing Tang 1 collaboration

Kaifu Chen 1 collaboration

Lihua Wang 1 collaboration

Xianwei Wang 1 collaboration

Xin Wang 1 collaboration

Stephanie Yu 1 collaboration

David L Williams 1 collaboration

Chuanfu Li 1 collaboration

Marion M Chan 1 collaboration

Dunne Fong 1 collaboration

Stephen Iwanowycz 1 collaboration

Diego Altomare 1 collaboration

Jianguo Liu 1 collaboration

Perry J Blackshear 1 collaboration

E Angela Murphy 1 collaboration

Fang Wang 1 collaboration

Qing Liu 1 collaboration

Udai P Singh 1 collaboration

Hexin Chen 1 collaboration

Ming Luo 1 collaboration

Walden Ai 1 collaboration

Aria Gillespie 1 collaboration

Hang Xi 1 collaboration

Çagla Tükel 1 collaboration

Domenico Pratico 1 collaboration

Alexander M Fagenson 1 collaboration

Kwan N Lau 1 collaboration

Antonio Di Carlo 1 collaboration

Sunil S Karhadkar 1 collaboration

Peng Tang 1 collaboration

Shuping Ge 1 collaboration

Gerard J Criner 1 collaboration

Charles Drummer I V 1 collaboration

Yong Li 1 collaboration

Wei Sun 1 collaboration

Quanyi Wang 1 collaboration

Yvonne Hui 1 collaboration

Sophia Yin 1 collaboration

Xiangqing Kong 1 collaboration

Ying Shao (邵颖) 1 collaboration

Yu Sun (孙宇) 1 collaboration

Keman Xu (徐克曼) 1 collaboration

Yifan Lu (路一凡) 1 collaboration

Dong Ni (倪栋) 1 collaboration

Xiaohua Jiang (蒋晓华) 1 collaboration

Hong Wang (王虹) 1 collaboration

Charles I V Drummer 1 collaboration

Na Wu 1 collaboration

Eleni Vasilopoulos 1 collaboration

Haitao Shen 1 collaboration

John R Bethea 1 collaboration

William Cornwell 1 collaboration

Aaron Kirchhoff 1 collaboration

Thomas J Rogers 1 collaboration

Jia 'Joe' Zhuo 1 collaboration

Yinghui Zhong 1 collaboration

Yujiang Pu 1 collaboration

Ying Tian 1 collaboration

Xiaolei Liu 1 collaboration

Jin Jun Luo 1 collaboration