Trained Immunity and Reactivity of Macrophages and Endothelial Cells.
Animals
Cardiovascular Diseases
/ etiology
Cytokines
/ biosynthesis
Endothelial Cells
/ immunology
Energy Metabolism
Epigenesis, Genetic
Humans
Immunity, Innate
Immunologic Memory
Infections
/ etiology
Inflammation
/ etiology
Macrophages
/ immunology
Metabolic Diseases
/ etiology
Metabolic Networks and Pathways
/ immunology
Models, Immunological
Reactive Oxygen Species
/ metabolism
Reperfusion Injury
/ etiology
Risk Factors
atherosclerosis
cardiovascular diseases
endothelial cells
macrophages
trained immunity
Journal
Arteriosclerosis, thrombosis, and vascular biology
ISSN: 1524-4636
Titre abrégé: Arterioscler Thromb Vasc Biol
Pays: United States
ID NLM: 9505803
Informations de publication
Date de publication:
03 2021
03 2021
Historique:
pubmed:
1
1
2021
medline:
16
3
2021
entrez:
31
12
2020
Statut:
ppublish
Résumé
Innate immune cells can develop exacerbated immunologic response and long-term inflammatory phenotype following brief exposure to endogenous or exogenous insults, which leads to an altered response towards a second challenge after the return to a nonactivated state. This phenomenon is known as trained immunity (TI). TI is not only important for host defense and vaccine response but also for chronic inflammations such as cardiovascular and metabolic diseases such as atherosclerosis. TI can occur in innate immune cells such as monocytes/macrophages, natural killer cells, endothelial cells (ECs), and nonimmune cells, such as fibroblast. In this brief review, we analyze the significance of TI in ECs, which are also considered as innate immune cells in addition to macrophages. TI can be induced by a variety of stimuli, including lipopolysaccharides, BCG (bacillus Calmette-Guerin), and oxLDL (oxidized low-density lipoprotein), which are defined as risk factors for cardiovascular and metabolic diseases. Furthermore, TI in ECs is functional for inflammation effectiveness and transition to chronic inflammation. Rewiring of cellular metabolism of the trained cells takes place during induction of TI, including increased glycolysis, glutaminolysis, increased accumulation of tricarboxylic acid cycle metabolites and acetyl-coenzyme A production, as well as increased mevalonate synthesis. Subsequently, this leads to epigenetic remodeling, resulting in important changes in chromatin architecture that enables increased gene transcription and enhanced proinflammatory immune response. However, TI pathways and inflammatory pathways are separated to ensure memory stays when inflammation undergoes resolution. Additionally, reactive oxygen species play context-dependent roles in TI. Therefore, TI plays significant roles in EC and macrophage pathology and chronic inflammation. However, further characterization of TI in ECs and macrophages would provide novel insights into cardiovascular disease pathogenesis and new therapeutic targets. Graphic Abstract: A graphic abstract is available for this article.
Identifiants
pubmed: 33380171
doi: 10.1161/ATVBAHA.120.315452
pmc: PMC7904591
mid: NIHMS1656862
doi:
Substances chimiques
Cytokines
0
Reactive Oxygen Species
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1032-1046Subventions
Organisme : NHLBI NIH HHS
ID : R01 HL138749
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL130233
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL131460
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK104116
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL132399
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL147565
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK113775
Pays : United States
Références
Circulation. 1993 Nov;88(5 Pt 1):2149-55
pubmed: 8222109
Science. 2016 Apr 22;352(6284):aaf1098
pubmed: 27102489
Nat Genet. 2019 Jan;51(1):138-150
pubmed: 30531872
J Hematol Oncol. 2014 Oct 31;7:80
pubmed: 25387998
Stroke. 2010 Mar;41(3):e117-22
pubmed: 20075350
Circulation. 2016 Aug 23;134(8):611-24
pubmed: 27496857
Angiology. 1999 Mar;50(3):201-8
pubmed: 10088799
J Gen Physiol. 1927 Mar 7;8(6):519-30
pubmed: 19872213
J Exp Med. 2012 May 7;209(5):947-54
pubmed: 22493516
Oncogene. 2010 Jan 21;29(3):313-24
pubmed: 19881548
Biochem Biophys Res Commun. 2013 Oct 11;440(1):105-11
pubmed: 24051091
Front Immunol. 2019 Jan 23;10:13
pubmed: 30728822
Am J Physiol. 1999 Jan;276(1):L9-L19
pubmed: 9887050
Cond Med. 2018 Aug;1(5):247-258
pubmed: 30338315
Clin Immunol. 2014 Dec;155(2):213-9
pubmed: 25451159
Cell Host Microbe. 2012 Aug 16;12(2):223-32
pubmed: 22901542
Cardiovasc Res. 2010 Oct 1;88(1):58-66
pubmed: 20558442
Nat Immunol. 2018 Dec;19(12):1403-1414
pubmed: 30397350
Arterioscler Thromb Vasc Biol. 2020 Jun;40(6):e138-e152
pubmed: 32459541
Cell Rep. 2016 Dec 6;17(10):2562-2571
pubmed: 27926861
Biol Chem. 2014 Apr;395(4):387-99
pubmed: 24445237
Immunity. 2018 Nov 20;49(5):819-828.e6
pubmed: 30413362
Front Biosci (Landmark Ed). 2019 Nov 1;24:96-132
pubmed: 30468648
Nat Rev Urol. 2014 Mar;11(3):153-62
pubmed: 24492433
Front Immunol. 2020 Feb 21;11:284
pubmed: 32153588
Sci Immunol. 2018 Dec 14;3(30):
pubmed: 30552101
Atherosclerosis. 2015 Apr;239(2):496-502
pubmed: 25721701
J Mol Med (Berl). 2020 Jul;98(7):1051
pubmed: 32529344
Am J Transplant. 2020 Jan;20(1):10-18
pubmed: 31561273
Immunity. 2015 Mar 17;42(3):419-30
pubmed: 25786174
Vaccine. 2009 Nov 16;27(49):6950-8
pubmed: 19747577
Am J Respir Crit Care Med. 2006 Jul 1;174(1):41-50
pubmed: 16574938
Cell Host Microbe. 2018 Jan 10;23(1):89-100.e5
pubmed: 29324233
Circ Res. 2016 May 13;118(10):1525-39
pubmed: 27006445
Nature. 2013 Apr 11;496(7444):238-42
pubmed: 23535595
Nat Immunol. 2015 Jul;16(7):675-9
pubmed: 26086132
Front Physiol. 2018 Oct 12;9:1297
pubmed: 30369883
J Immunol. 2010 May 15;184(10):5562-70
pubmed: 20382886
J Virol. 2005 Jan;79(1):264-76
pubmed: 15596822
Nat Immunol. 2006 May;7(5):507-16
pubmed: 16617337
Innate Immun. 2015 Aug;21(6):565-74
pubmed: 25540284
J Neurosci. 2010 May 5;30(18):6398-408
pubmed: 20445066
Cell. 2018 Jan 11;172(1-2):135-146.e9
pubmed: 29328908
Expert Rev Anticancer Ther. 2011 Nov;11(11):1671-6
pubmed: 22050015
mBio. 2018 May 22;9(3):
pubmed: 29789368
Circulation. 2009 Nov 10;120(19):1893-902
pubmed: 19858416
Arterioscler Thromb Vasc Biol. 2014 Aug;34(8):1731-8
pubmed: 24903093
Science. 2014 Sep 26;345(6204):1251086
pubmed: 25258085
Curr Opin HIV AIDS. 2011 Jul;6(4):266-71
pubmed: 21546831
Pathogens. 2020 Oct 24;9(11):
pubmed: 33114395
Arterioscler Thromb Vasc Biol. 2019 Oct;39(10):2097-2119
pubmed: 31366217
Cell Stem Cell. 2020 May 7;26(5):793
pubmed: 32386557
J Clin Med. 2020 May 11;9(5):
pubmed: 32403217
N Engl J Med. 2020 Sep 10;383(11):1078-1080
pubmed: 32905684
Hypertension. 2018 Apr;71(4):761-770
pubmed: 29507101
Prog Cardiovasc Dis. 2007 Sep-Oct;50(2):112-25
pubmed: 17765473
J Hematol Oncol. 2013 Aug 22;6:61
pubmed: 23965413
Cell. 2013 Jan 17;152(1-2):157-71
pubmed: 23332752
N Engl J Med. 2019 Jan 10;380(2):171-176
pubmed: 30625066
J Cardiovasc Transl Res. 2016 Aug;9(4):343-59
pubmed: 27230673
Nat Immunol. 2015 Oct;16(10):1034-43
pubmed: 26322480
Cell Metab. 2017 Jul 5;26(1):142-156
pubmed: 28683282
Cell Metab. 2016 Dec 13;24(6):807-819
pubmed: 27866838
J Innate Immun. 2014;6(2):152-8
pubmed: 24192057
Am J Respir Cell Mol Biol. 2016 May;54(5):683-96
pubmed: 26452072
Phlebology. 2016 Oct;31(9):625-31
pubmed: 26405065
Epigenetics Chromatin. 2019 Nov 11;12(1):65
pubmed: 31711545
Cold Spring Harb Perspect Med. 2012 Jan;2(1):a006429
pubmed: 22315715
Thromb Res. 2020 Dec;196:143-151
pubmed: 32871306
J Neurochem. 2010 Jun;113(6):1685-91
pubmed: 20402966
J Am Coll Cardiol. 2010 May 4;55(18):1988-95
pubmed: 20236788
Redox Biol. 2020 Jan;28:101373
pubmed: 31731100
Nature. 2013 Oct 24;502(7472):489-98
pubmed: 24153302
J Mol Cell Cardiol. 2020 Sep;146:121-132
pubmed: 32726647
J Virol. 2012 Jun;86(12):6408-15
pubmed: 22496214
Front Immunol. 2017 Dec 01;8:1714
pubmed: 29250078
Redox Biol. 2019 Jun;24:101221
pubmed: 31153039
Cell. 2018 Jan 11;172(1-2):162-175.e14
pubmed: 29328911
Neurotherapeutics. 2013 Oct;10(4):789-97
pubmed: 23868468
Thromb Res. 2011 Sep;128(3):216-20
pubmed: 21620438
J Biol Chem. 2010 Jun 11;285(24):18217-24
pubmed: 20368331
Int Immunopharmacol. 2015 Sep;28(1):655-65
pubmed: 26253657
Nat Rev Immunol. 2015 Feb;15(2):104-16
pubmed: 25614320
Cardiovasc Res. 2020 Feb 1;116(2):317-328
pubmed: 31119285
Redox Biol. 2020 Oct;37:101759
pubmed: 33086106
Trends Endocrinol Metab. 2018 Sep;29(9):602-605
pubmed: 29627292
Nat Rev Immunol. 2020 Jun;20(6):375-388
pubmed: 32132681
Science. 2014 Sep 26;345(6204):1250684
pubmed: 25258083
J Cereb Blood Flow Metab. 2010 Apr;30(4):744-56
pubmed: 20010955
Circulation. 2007 Mar 13;115(10):1285-95
pubmed: 17353456
Am J Physiol Heart Circ Physiol. 2003 Jun;284(6):H2053-60
pubmed: 12521944
Front Immunol. 2020 Oct 19;11:554301
pubmed: 33193322
Eur J Prev Cardiol. 2017 Dec;24(18):1958-1966
pubmed: 28764553
Can J Cardiol. 2020 May;36(5):635-647
pubmed: 32389337
Redox Biol. 2020 Oct;37:101696
pubmed: 32950427
J Am Coll Cardiol. 2004 May 19;43(10):1731-7
pubmed: 15145091
Front Immunol. 2019 Jan 22;9:3155
pubmed: 30723479
Nat Rev Nephrol. 2017 Jun;13(6):368-380
pubmed: 28392564
Nat Commun. 2019 Dec 11;10(1):5670
pubmed: 31827093
Cardiovasc Res. 2018 Sep 1;114(11):1547-1563
pubmed: 29800237
Science. 2009 May 22;324(5930):1076-80
pubmed: 19461003
Infect Immun. 2011 Sep;79(9):3576-87
pubmed: 21646453
PLoS One. 2015 May 04;10(5):e0125342
pubmed: 25938548
J Leukoc Biol. 2014 Nov;96(5):833-41
pubmed: 25024399
Biochim Biophys Acta. 1989 Nov 23;977(2):171-6
pubmed: 2804096
J Immunol. 2005 Nov 15;175(10):6265-70
pubmed: 16272276
Am J Pathol. 2000 Jan;156(1):287-93
pubmed: 10623677
Novartis Found Symp. 2006;277:3-16; discussion 16-22, 71-3, 251-3
pubmed: 17319151
Clin Infect Dis. 2017 Oct 1;65(7):1183-1190
pubmed: 29579158
Front Physiol. 2012 May 07;3:128
pubmed: 22586409
Circ Res. 2007 Feb 2;100(2):174-90
pubmed: 17272819
Mol Aspects Med. 2021 Feb;77:100897
pubmed: 32891423
Antioxid Redox Signal. 2018 Oct 10;29(11):1023-1040
pubmed: 28978221
Clin Infect Dis. 2016 Aug 15;63(4):495-500
pubmed: 27193746
Am J Epidemiol. 1984 Nov;120(5):653-69
pubmed: 6496446
Immunity. 2015 Mar 17;42(3):443-56
pubmed: 25786176
Arterioscler Thromb Vasc Biol. 2017 Nov;37(11):2087-2101
pubmed: 28882872
Redox Biol. 2020 Oct;37:101609
pubmed: 32591281
Mol Cancer Res. 2020 Jan;18(1):166-178
pubmed: 31619507
Arterioscler Thromb Vasc Biol. 2008 Mar;28(3):387-91
pubmed: 18296594
Cell. 2018 Jan 11;172(1-2):147-161.e12
pubmed: 29328910
Am J Physiol. 1997 Oct;273(4):C1233-40
pubmed: 9357767
Front Cell Dev Biol. 2018 Aug 07;6:82
pubmed: 30131957
Proc Natl Acad Sci U S A. 2012 Oct 23;109(43):17537-42
pubmed: 22988082
Circulation. 2008 Oct 28;118(18):1837-47
pubmed: 18852364
Cell Mol Life Sci. 2008 Oct;65(20):3231-40
pubmed: 18668203
J Biol Chem. 2015 Jul 10;290(28):17485-94
pubmed: 26037927
J Biol Chem. 2017 Jan 27;292(4):1267-1287
pubmed: 27856635
Am J Respir Crit Care Med. 2016 Jul 15;194(2):209-17
pubmed: 26808711
Circ Res. 2012 Jun 22;111(1):37-49
pubmed: 22628578
Eur Surg. 2016;48:92-98
pubmed: 27110233
Chin Med J (Engl). 2012 Nov;125(22):3997-4002
pubmed: 23158132
Clin Vaccine Immunol. 2014 Apr;21(4):534-45
pubmed: 24521784
Atherosclerosis. 2016 Nov;254:228-236
pubmed: 27764724
Nature. 2009 Jan 29;457(7229):557-61
pubmed: 19136945
Cell Mol Immunol. 2016 May;13(3):369-78
pubmed: 25942600
Retrovirology. 2013 Jul 17;10:73
pubmed: 23866860
Pharmacol Ther. 2020 Oct 24;:107715
pubmed: 33141028
Arterioscler Thromb Vasc Biol. 2015 Apr;35(4):804-16
pubmed: 25705917
Front Biosci (Landmark Ed). 2013 Jan 01;18:638-49
pubmed: 23276949
Front Immunol. 2020 Oct 14;11:595813
pubmed: 33154757
Clin Vaccine Immunol. 2016 Dec 5;23(12):926-933
pubmed: 27733422
Front Immunol. 2018 Apr 19;9:799
pubmed: 29725331
Nature. 1959 Jul 25;184(Suppl 5):291-2
pubmed: 14428599
Nat Rev Drug Discov. 2019 Jul;18(7):553-566
pubmed: 30967658
Am J Physiol. 1996 Sep;271(3 Pt 2):H842-9
pubmed: 8853316
FASEB J. 2019 Nov;33(11):11993-12007
pubmed: 31393790
J Am Heart Assoc. 2017 Jul 6;6(7):
pubmed: 28684641
Cardiovasc Hematol Disord Drug Targets. 2014;14(1):3-14
pubmed: 25088124
Elife. 2017 May 30;6:
pubmed: 28556776
Cell Rep. 2020 Apr 21;31(3):107548
pubmed: 32320649
Nat Rev Immunol. 2019 Apr;19(4):218-230
pubmed: 30679808
Sci Rep. 2016 Dec 12;6:38975
pubmed: 27941911
Am J Transl Res. 2016 Feb 15;8(2):765-77
pubmed: 27158368
Circ Res. 2018 Mar 2;122(5):664-669
pubmed: 29367213
Mol Immunol. 2015 Dec;68(2 Pt C):513-9
pubmed: 26260211