A Novel Subset of CD95
Adipose Tissue, White
/ metabolism
Animals
Aorta
Aortic Diseases
/ etiology
Atherosclerosis
/ etiology
B7-2 Antigen
/ analysis
Cells, Cultured
Culture Media, Conditioned
/ pharmacology
Diet, High-Fat
/ adverse effects
Disease Progression
Endothelial Cells
/ drug effects
Female
Humans
Inflammation
/ complications
Intercellular Adhesion Molecule-1
/ biosynthesis
Macrophages
/ chemistry
Male
Mice
Mice, Inbred C57BL
Mice, Knockout, ApoE
MicroRNAs
/ physiology
Obesity, Metabolically Benign
/ immunology
Vasculitis
/ etiology
fas Receptor
/ analysis
CD95 (Fas)
Macrophage
adipose tissue
atherosclerosis
metabolic
metabolic disease
miR-155
obesity
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2020
2020
Historique:
received:
21
10
2020
accepted:
20
11
2020
entrez:
25
1
2021
pubmed:
26
1
2021
medline:
8
7
2021
Statut:
epublish
Résumé
Metabolically healthy obesity (MHO) accounts for roughly 35% of all obese patients. There is no clear consensus that has been reached on whether MHO is a stable condition or merely a transitory period between metabolically healthy lean and metabolically unhealthy obesity (MUO). Additionally, the mechanisms underlying MHO and any transition to MUO are not clear. Macrophages are the most common immune cells in adipose tissues and have a significant presence in atherosclerosis. Fas (or CD95), which is highly expressed on macrophages, is classically recognized as a pro-apoptotic cell surface receptor. However, Fas also plays a significant role as a pro-inflammatory molecule. Previously, we established a mouse model (ApoE
Identifiants
pubmed: 33488632
doi: 10.3389/fimmu.2020.619951
pmc: PMC7817616
doi:
Substances chimiques
B7-2 Antigen
0
Cd86 protein, mouse
0
Culture Media, Conditioned
0
ICAM1 protein, human
0
MicroRNAs
0
Mirn155 microRNA, mouse
0
fas Receptor
0
Intercellular Adhesion Molecule-1
126547-89-5
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
619951Subventions
Organisme : NHLBI NIH HHS
ID : R01 HL138749
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL130233
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL131460
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK104116
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL147565
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK113775
Pays : United States
Informations de copyright
Copyright © 2021 Johnson, Drummer IV, Shan, Shao, Sun, Lu, Saaoud, Xu, Nanayakkara, Fang, Bagi, Jiang, Choi, Wang and Yang.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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