The role of 5-lipoxygenase in the pathophysiology of COVID-19 and its therapeutic implications.
Animals
Arachidonate 5-Lipoxygenase
/ metabolism
Arachidonic Acid
/ metabolism
COVID-19
/ enzymology
Cytokine Release Syndrome
Cytokines
/ metabolism
Enzyme Inhibitors
/ pharmacology
Humans
Inflammation
Interleukins
/ metabolism
Leukotrienes
/ metabolism
Lipoxygenase Inhibitors
/ pharmacology
SARS-CoV-2
Treatment Outcome
Virus Diseases
/ drug therapy
COVID-19 Drug Treatment
5-LOX inhibitors
5-lipoxygenase
COVID-19
CRS
SARS-CoV-2
Journal
Inflammation research : official journal of the European Histamine Research Society ... [et al.]
ISSN: 1420-908X
Titre abrégé: Inflamm Res
Pays: Switzerland
ID NLM: 9508160
Informations de publication
Date de publication:
Aug 2021
Aug 2021
Historique:
received:
15
12
2020
accepted:
15
05
2021
revised:
21
04
2021
pubmed:
5
6
2021
medline:
10
8
2021
entrez:
4
6
2021
Statut:
ppublish
Résumé
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, known as coronavirus disease 2019 (COVID-19) causes cytokine release syndrome (CRS), leading to acute respiratory distress syndrome (ARDS), acute kidney and cardiac injury, liver dysfunction, and multiorgan failure. Although several studies have discussed the role of 5-lipoxygenase (5-LOX) in viral infections, such as influenzae and SARS, it remains unexplored in the pathophysiology of COVID-19. 5-LOX acts on free arachidonic acid (AA) to form proinflammatory leukotrienes (LTs). Of note, numerous cells involved with COVID-19 (e.g., inflammatory and smooth muscle cells, platelets, and vascular endothelium) widely express leukotriene receptors. Moreover, 5-LOX metabolites induce the release of cytokines (e.g., tumour necrosis factor-α [TNF-α], interleukin-1α [IL-1α], and interleukin-1β [IL-1β]) and express tissue factor on cell membranes and activate plasmin. Since macrophages, monocytes, neutrophils, and eosinophils can express lipoxygenases, activation of 5-LOX and the subsequent release of LTs may contribute to the severity of COVID-19. This review sheds light on the potential implications of 5-LOX in SARS-CoV-2-mediated infection and the anticipated therapeutic role of 5-LOX inhibitors.
Identifiants
pubmed: 34086061
doi: 10.1007/s00011-021-01473-y
pii: 10.1007/s00011-021-01473-y
pmc: PMC8176665
doi:
Substances chimiques
Cytokines
0
Enzyme Inhibitors
0
Interleukins
0
Leukotrienes
0
Lipoxygenase Inhibitors
0
Arachidonic Acid
27YG812J1I
Arachidonate 5-Lipoxygenase
EC 1.13.11.34
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
877-889Informations de copyright
© 2021. The Author(s), under exclusive licence to Springer Nature Switzerland AG.
Références
Am J Respir Crit Care Med. 2002 Jan 15;165(2):229-35
pubmed: 11790660
Cell Death Differ. 2020 May;27(5):1451-1454
pubmed: 32205856
JAMA. 2020 Apr 7;323(13):1239-1242
pubmed: 32091533
Cell Mol Immunol. 2016 Jul;13(4):432-42
pubmed: 27041635
Crit Care. 2020 May 6;24(1):198
pubmed: 32375845
Arch Med Res. 2020 Apr;51(3):282-286
pubmed: 32229155
Circ Res. 2020 May 8;126(10):1443-1455
pubmed: 32252591
N Engl J Med. 2020 May 7;382(19):1787-1799
pubmed: 32187464
Int J Gen Med. 2013 Dec 09;6:897-903
pubmed: 24357936
bioRxiv. 2020 Dec 24;:
pubmed: 33398280
J Biomed Biotechnol. 2004;2004(2):99-105
pubmed: 15240920
Immunity. 2014 Mar 20;40(3):315-27
pubmed: 24656045
Cancer Metastasis Rev. 2020 Jun;39(2):337-340
pubmed: 32385712
Mucosal Immunol. 2014 May;7(3):549-57
pubmed: 24064666
Travel Med Infect Dis. 2020 Jan - Feb;33:101567
pubmed: 32006657
J Immunol. 2014 Mar 1;192(5):2349-56
pubmed: 24477912
Am J Physiol Renal Physiol. 2019 Apr 1;316(4):F732-F742
pubmed: 30649890
Front Cell Neurosci. 2015 Jan 14;8:436
pubmed: 25642165
Dermatol Ther. 2020 Sep;33(5):e13549
pubmed: 32390279
Am J Physiol Heart Circ Physiol. 2006 Oct;291(4):H1679-85
pubmed: 16714363
Cell. 2020 May 14;181(4):914-921.e10
pubmed: 32330414
Ann Rheum Dis. 2003 Jun;62(6):501-9
pubmed: 12759283
Redox Biol. 2015 Dec;6:297-310
pubmed: 26298204
PLoS One. 2011;6(8):e23730
pubmed: 21904596
Antiviral Res. 2017 Jul;143:142-150
pubmed: 28390872
Arthritis Rheum. 2001 Feb;45(1):86-100
pubmed: 11308068
Lancet. 2003 May 24;361(9371):1767-72
pubmed: 12781535
Semin Diagn Pathol. 2019 May;36(3):152-159
pubmed: 31054790
Curr Rheumatol Rep. 2009 Oct;11(5):357-64
pubmed: 19772831
Bone Res. 2020 Feb 14;8:8
pubmed: 32128276
JAMA. 2020 Apr 28;323(16):1612-1614
pubmed: 32191259
Eur J Pharmacol. 2018 May 15;827:181-188
pubmed: 29548973
J Clin Invest. 2018 Jul 2;128(7):2680-2690
pubmed: 30108195
Br J Pharmacol. 1991 Mar;102(3):769-73
pubmed: 1364851
Mediators Inflamm. 2012;2012:236345
pubmed: 22665949
Expert Opin Ther Targets. 2018 Jan;22(1):31-44
pubmed: 29168929
J Am Soc Nephrol. 2020 Jul;31(7):1380-1383
pubmed: 32366514
Infect Immun. 2004 Aug;72(8):4410-5
pubmed: 15271897
Am J Hematol. 2020 Jul;95(7):834-847
pubmed: 32282949
Nat Rev Immunol. 2020 Jun;20(6):343-344
pubmed: 32327719
Eur J Med Chem. 2018 Jun 10;153:65-72
pubmed: 29133059
J Med Virol. 2020 May;92(5):491-494
pubmed: 32056249
Am J Pathol. 2007 Sep;171(3):715-27
pubmed: 17640961
J Physiol. 1961 Aug;157:589-602
pubmed: 13701120
Prostaglandins Other Lipid Mediat. 2019 Jun;142:24-32
pubmed: 30930090
Circulation. 2020 Jul 7;142(1):68-78
pubmed: 32293910
PLoS One. 2014 Jul 15;9(7):e102622
pubmed: 25025775
Am J Respir Crit Care Med. 2002 Jan 15;165(2):146-7
pubmed: 11790644
Prog Neuropsychopharmacol Biol Psychiatry. 2011 Mar 30;35(2):315-9
pubmed: 20691748
Peptides. 2014 Feb;52:82-9
pubmed: 24361511
Crit Care Med. 1992 Apr;20(4):468-73
pubmed: 1559358
Eur Respir J. 2020 Apr 16;55(4):
pubmed: 32269085
Thromb Haemost. 2020 Jun;120(6):949-956
pubmed: 32349133
Viruses. 2019 Jan 16;11(1):
pubmed: 30654597
J Inflamm Res. 2018 Dec 11;11:477-502
pubmed: 30588058
Pharmacol Rep. 2010 May-Jun;62(3):503-10
pubmed: 20631414
J Clin Invest. 2011 Jun;121(6):2264-77
pubmed: 21576823
J Thromb Haemost. 2020 Jul;18(7):1559-1561
pubmed: 32302453
Nat Microbiol. 2016 Feb 22;1:16004
pubmed: 27572168
J Allergy Clin Immunol. 1999 Apr;103(4):630-6
pubmed: 10200012
Mol Med Rep. 2018 May;17(5):6935-6941
pubmed: 29568899
PLoS One. 2014 Sep 17;9(9):e107890
pubmed: 25229347
Clin Microbiol Rev. 2020 Jun 24;33(4):
pubmed: 32580969
J Clin Virol. 2020 Jun;127:104357
pubmed: 32305884
Nat Rev Immunol. 2020 Jul;20(7):448
pubmed: 32488203
Circ Res. 2000 Sep 1;87(5):E1-9
pubmed: 10969042
Blood. 1994 Apr 1;83(7):1941-51
pubmed: 8142660
J Pharmacol Exp Ther. 2010 Jul;334(1):294-301
pubmed: 20378715
Ann Clin Microbiol Antimicrob. 2020 Sep 2;19(1):40
pubmed: 32878641
Allergy. 2020 Jul;75(7):1564-1581
pubmed: 32396996
Clin Vaccine Immunol. 2013 Mar;20(3):319-27
pubmed: 23283640
World Neurosurg. 2020 Jul;139:344-354
pubmed: 32387786
Front Immunol. 2019 Jun 28;10:1347
pubmed: 31316498
Medchemcomm. 2017 Nov 29;9(2):212-225
pubmed: 30108915
Biochim Biophys Acta Mol Cell Biol Lipids. 2020 Sep;1865(9):158702
pubmed: 32222425
Arterioscler Thromb Vasc Biol. 2006 Jun;26(6):1204-6
pubmed: 16709954
J Infect. 2020 Jun;80(6):607-613
pubmed: 32283152
J Leukoc Biol. 2004 Nov;76(5):961-70
pubmed: 15328337
J Autoimmun. 2020 May;109:102434
pubmed: 32143990
Nat Immunol. 2005 Apr;6(4):353-60
pubmed: 15785761
Acta Pharmacol Sin. 2007 Jun;28(6):763-72
pubmed: 17506934
Life Sci. 2020 Jul 15;253:117723
pubmed: 32360126
J Pharm Pharmacol. 1996 Jan;48(1):46-52
pubmed: 8722494
Am J Pathol. 2003 Dec;163(6):2371-82
pubmed: 14633609
Agents Actions. 1992;Spec No:C37-46
pubmed: 1359745
PLoS One. 2012;7(9):e45480
pubmed: 23029040
Eur J Clin Pharmacol. 2020 Nov;76(11):1501-1504
pubmed: 32583353
Int J Mol Sci. 2019 Jul 22;20(14):
pubmed: 31336653
Cardiovasc Res. 2010 May 1;86(2):243-53
pubmed: 20093252
Biochim Biophys Acta. 2015 Apr;1851(4):331-9
pubmed: 25152163
Br J Pharmacol. 2015 Sep;172(17):4319-30
pubmed: 26040494
Biochem Pharmacol. 2016 Nov 1;119:17-26
pubmed: 27592027
J Heart Lung Transplant. 2020 May;39(5):405-407
pubmed: 32362390
Lancet. 2020 Feb 15;395(10223):507-513
pubmed: 32007143
Indian J Exp Biol. 2005 Dec;43(12):1150-5
pubmed: 16359126
J Thorac Oncol. 2020 May;15(5):700-704
pubmed: 32114094
PLoS One. 2011;6(9):e24774
pubmed: 21931850
Crit Care Med. 2002 May;30(5):1015-23
pubmed: 12006796
Lancet. 2003 May 24;361(9371):1773-8
pubmed: 12781536
Cell Host Microbe. 2020 Jun 10;27(6):879-882.e2
pubmed: 32359396
Front Immunol. 2014 Oct 17;5:514
pubmed: 25368618
Nat Rev Immunol. 2020 Jun;20(6):363-374
pubmed: 32346093
Viral Immunol. 2012 Aug;25(4):277-88
pubmed: 22876772
Cardiovasc Res. 2020 Aug 1;116(10):1666-1687
pubmed: 32352535
Cell. 2013 Jul 3;154(1):213-27
pubmed: 23827684
J Infect Dis. 2016 Feb 15;213(4):532-40
pubmed: 26310310
Biochim Biophys Acta. 2014 Nov;1843(11):2563-2582
pubmed: 24892271
J Biochem. 2015 Feb;157(2):65-71
pubmed: 25480980