Polyunsaturated Fatty Acid Levels and the Risk of Keratinocyte Cancer: A Mendelian Randomization Analysis.
Adult
Aged
Australia
/ epidemiology
Biomarkers, Tumor
/ blood
Carcinoma, Basal Cell
/ epidemiology
Carcinoma, Squamous Cell
/ epidemiology
Fatty Acids, Unsaturated
/ blood
Female
Genome-Wide Association Study
Humans
Keratinocytes
/ pathology
Male
Mendelian Randomization Analysis
Middle Aged
Polymorphism, Single Nucleotide
Risk Factors
Skin Neoplasms
/ epidemiology
United Kingdom
/ epidemiology
Journal
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
ISSN: 1538-7755
Titre abrégé: Cancer Epidemiol Biomarkers Prev
Pays: United States
ID NLM: 9200608
Informations de publication
Date de publication:
08 2021
08 2021
Historique:
received:
13
12
2020
revised:
20
02
2021
accepted:
19
05
2021
pubmed:
6
6
2021
medline:
25
2
2022
entrez:
5
6
2021
Statut:
ppublish
Résumé
Keratinocyte cancer is the commonest cancer, imposing a high economic burden on the health care system. Observational studies have shown mixed associations between polyunsaturated fatty acids (PUFA) and keratinocyte cancer, basal cell carcinoma (BCC), and squamous cell carcinoma (SCC). We explored whether genetically predicted PUFA levels are associated with BCC and SCC risks. We conducted a two-sample Mendelian randomization study using PUFA level genome-wide association studies (GWAS) from the Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium ( One SD increase in genetically predicted levels of linoleic acid [OR = 0.94, 95% confidence interval (CI) = 0.91-0.97, Higher genetically predicted levels of linoleic acid and alpha-linolenic acid were associated with a reduced BCC risk, but arachidonic acid and eicosapentaenoic acid were associated with a higher BCC risk. PUFA-related diet and supplementation could influence BCC etiology.
Sections du résumé
BACKGROUND
Keratinocyte cancer is the commonest cancer, imposing a high economic burden on the health care system. Observational studies have shown mixed associations between polyunsaturated fatty acids (PUFA) and keratinocyte cancer, basal cell carcinoma (BCC), and squamous cell carcinoma (SCC). We explored whether genetically predicted PUFA levels are associated with BCC and SCC risks.
METHODS
We conducted a two-sample Mendelian randomization study using PUFA level genome-wide association studies (GWAS) from the Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium (
RESULTS
One SD increase in genetically predicted levels of linoleic acid [OR = 0.94, 95% confidence interval (CI) = 0.91-0.97,
CONCLUSIONS
Higher genetically predicted levels of linoleic acid and alpha-linolenic acid were associated with a reduced BCC risk, but arachidonic acid and eicosapentaenoic acid were associated with a higher BCC risk.
IMPACT
PUFA-related diet and supplementation could influence BCC etiology.
Identifiants
pubmed: 34088753
pii: 1055-9965.EPI-20-1765
doi: 10.1158/1055-9965.EPI-20-1765
pmc: PMC9306272
doi:
Substances chimiques
Biomarkers, Tumor
0
Fatty Acids, Unsaturated
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1591-1598Informations de copyright
©2021 The Authors; Published by the American Association for Cancer Research.
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