Long-term exposure to low-level air pollution and incidence of asthma: the ELAPSE project.

Adult Air Pollutants / analysis Air Pollution / analysis Asthma Child Environmental Exposure / analysis Europe Humans Incidence Particulate Matter / analysis Sweden

Journal

The European respiratory journal
ISSN: 1399-3003
Titre abrégé: Eur Respir J
Pays: England
ID NLM: 8803460

Informations de publication

Date de publication:
06 2021
Historique:
received: 11 08 2020
accepted: 17 11 2020
entrez: 5 6 2021
pubmed: 6 6 2021
medline: 6 7 2021
Statut: epublish

Résumé

Long-term exposure to ambient air pollution has been linked to childhood-onset asthma, although evidence is still insufficient. Within the multicentre project Effects of Low-Level Air Pollution: A Study in Europe (ELAPSE), we examined the associations of long-term exposures to particulate matter with a diameter <2.5 µm (PM We pooled data from three cohorts in Denmark and Sweden with information on asthma hospital diagnoses. The average concentrations of air pollutants in 2010 were modelled by hybrid land-use regression models at participants' baseline residential addresses. Associations of air pollution exposures with asthma incidence were explored with Cox proportional hazard models, adjusting for potential confounders. Of 98 326 participants, 1965 developed asthma during a mean follow-up of 16.6 years. We observed associations in fully adjusted models with hazard ratios of 1.22 (95% CI 1.04-1.43) per 5 μg·m Long-term exposure to air pollution, especially from fossil fuel combustion sources such as motorised traffic, was associated with adult-onset asthma, even at levels below the current limit values.

Sections du résumé

BACKGROUND
Long-term exposure to ambient air pollution has been linked to childhood-onset asthma, although evidence is still insufficient. Within the multicentre project Effects of Low-Level Air Pollution: A Study in Europe (ELAPSE), we examined the associations of long-term exposures to particulate matter with a diameter <2.5 µm (PM
METHODS
We pooled data from three cohorts in Denmark and Sweden with information on asthma hospital diagnoses. The average concentrations of air pollutants in 2010 were modelled by hybrid land-use regression models at participants' baseline residential addresses. Associations of air pollution exposures with asthma incidence were explored with Cox proportional hazard models, adjusting for potential confounders.
RESULTS
Of 98 326 participants, 1965 developed asthma during a mean follow-up of 16.6 years. We observed associations in fully adjusted models with hazard ratios of 1.22 (95% CI 1.04-1.43) per 5 μg·m
CONCLUSIONS
Long-term exposure to air pollution, especially from fossil fuel combustion sources such as motorised traffic, was associated with adult-onset asthma, even at levels below the current limit values.

Identifiants

DOI: 10.1183/13993003.03099-2020 PMID: 34088754
pubmed: 34088754
pii: 57/6/2003099
doi: 10.1183/13993003.03099-2020
pii:
doi:

Substances chimiques

Air Pollutants 0
Particulate Matter 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : Medical Research Council
ID : MR/S019669/1
Pays : United Kingdom

Commentaires et corrections

Type : CommentIn

Informations de copyright

Copyright ©ERS 2021.

Déclaration de conflit d'intérêts

Conflict of interest: S. Liu has nothing to disclose. Conflict of interest: J.T. Jørgensen has nothing to disclose. Conflict of interest: P. Ljungman has nothing to disclose. Conflict of interest: G. Pershagen has nothing to disclose. Conflict of interest: T. Bellander has nothing to disclose. Conflict of interest: K. Leander has nothing to disclose. Conflict of interest: P.K.E. Magnusson has nothing to disclose. Conflict of interest: D. Rizzuto has nothing to disclose. Conflict of interest: U.A. Hvidtfeldt has nothing to disclose. Conflict of interest: O. Raaschou-Nielsen has nothing to disclose. Conflict of interest: K. Wolf has nothing to disclose. Conflict of interest: B. Hoffmann has nothing to disclose. Conflict of interest: B. Brunekreef has nothing to disclose. Conflict of interest: M. Strak has nothing to disclose. Conflict of interest: J. Chen has nothing to disclose. Conflict of interest: A. Mehta has nothing to disclose. Conflict of interest: R.W. Atkinson has nothing to disclose. Conflict of interest: M. Bauwelinck has nothing to disclose. Conflict of interest: R. Varraso has nothing to disclose. Conflict of interest: M-C. Boutron-Ruault has nothing to disclose. Conflict of interest: J. Brandt has nothing to disclose. Conflict of interest: G. Cesaroni has nothing to disclose. Conflict of interest: F. Forastiere has nothing to disclose. Conflict of interest: D. Fecht has nothing to disclose. Conflict of interest: J. Gulliver has nothing to disclose. Conflict of interest: O. Hertel has nothing to disclose. Conflict of interest: K. de Hoogh has nothing to disclose. Conflict of interest: N.A.H. Janssen has nothing to disclose. Conflict of interest: K. Katsouyanni has nothing to disclose. Conflict of interest: M. Ketzel has nothing to disclose. Conflict of interest: J.O. Klompmaker has nothing to disclose. Conflict of interest: G. Nagel has nothing to disclose. Conflict of interest: B. Oftedal has nothing to disclose. Conflict of interest: A. Peters has nothing to disclose. Conflict of interest: A. Tjønneland has nothing to disclose. Conflict of interest: S.P. Rodopoulou has nothing to disclose. Conflict of interest: E Samoli has nothing to disclose. Conflict of interest: D.T. Kristoffersen has nothing to disclose. Conflict of interest: T. Sigsgaard has nothing to disclose. Conflict of interest: M. Stafoggia has nothing to disclose. Conflict of interest: D. Vienneau has nothing to disclose. Conflict of interest: G. Weinmayr has nothing to disclose. Conflict of interest: G. Hoek has nothing to disclose. Conflict of interest: Z.J. Andersen has nothing to disclose.

Auteurs

Shuo Liu (S)

Dept of Public Health, University of Copenhagen, Copenhagen, Denmark.

Jeanette Therming Jørgensen (JT)

Dept of Public Health, University of Copenhagen, Copenhagen, Denmark.

Petter Ljungman (P)

Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Dept of Cardiology, Danderyd University Hospital, Stockholm, Sweden.

Göran Pershagen (G)

Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Center for Occupational and Environmental Medicine, Region Stockholm, Stockholm, Sweden.

Tom Bellander (T)

Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Center for Occupational and Environmental Medicine, Region Stockholm, Stockholm, Sweden.

Karin Leander (K)

Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
ORCID: 0000-0002-1404-9222

Patrik K E Magnusson (PKE)

Dept of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
ORCID: 0000-0002-7315-7899

Debora Rizzuto (D)

Aging Research Center, Dept of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm, Sweden.
The Stockholm Gerontology Research Center, Stockholm, Sweden.

Ulla A Hvidtfeldt (UA)

Danish Cancer Society Research Center, Copenhagen, Denmark.

Ole Raaschou-Nielsen (O)

Danish Cancer Society Research Center, Copenhagen, Denmark.
Dept of Environmental Science, Aarhus University, Roskilde, Denmark.

Kathrin Wolf (K)

Institute of Epidemiology, Helmholtz Zentrum München, Neuherberg, Germany.

Barbara Hoffmann (B)

Institute of Occupational, Social and Environmental Medicine, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.

Bert Brunekreef (B)

Institute for Risk Assessment Sciences (IRAS), Utrecht University, Utrecht, The Netherlands.

Maciej Strak (M)

Institute for Risk Assessment Sciences (IRAS), Utrecht University, Utrecht, The Netherlands.
National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands.

Jie Chen (J)

Institute for Risk Assessment Sciences (IRAS), Utrecht University, Utrecht, The Netherlands.

Amar Mehta (A)

Dept of Public Health, University of Copenhagen, Copenhagen, Denmark.

Richard W Atkinson (RW)

Population Health Research Institute, St George's, University of London, London, UK.

Mariska Bauwelinck (M)

Interface Demography, Dept of Sociology, Vrije Universiteit Brussel, Brussels, Belgium.

Raphaëlle Varraso (R)

CESP, Faculté de Médecine, Université Paris-Saclay, UVSQ, Inserm UMR 1018, Villejuif, France.

Marie-Christine Boutron-Ruault (MC)

CESP, Faculté de Médecine, Université Paris-Saclay, UVSQ, Inserm UMR 1018, Villejuif, France.
Gustave Roussy, Villejuif, France.

Jørgen Brandt (J)

Dept of Environmental Science, Aarhus University, Roskilde, Denmark.
iClimate, Aarhus University Interdisciplinary Center for Climate Change, Roskilde, Denmark.

Giulia Cesaroni (G)

Dept of Epidemiology, Lazio Regional Health Service, ASL Roma 1, Rome, Italy.

Francesco Forastiere (F)

Dept of Epidemiology, Lazio Regional Health Service, ASL Roma 1, Rome, Italy.

Daniela Fecht (D)

MRC Centre for Environment and Health, School of Public Health, Imperial College London, London, UK.

John Gulliver (J)

UK Small Area Health Statistics Unit, Dept of Epidemiology and Biostatistics, Imperial College London, London, UK.
Centre for Environmental Health and Sustainability and School of Geography, Geology and the Environment, University of Leicester, Leicester, UK.

Ole Hertel (O)

Dept of Environmental Science, Aarhus University, Roskilde, Denmark.

Kees de Hoogh (K)

Swiss Tropical and Public Health Institute, Basel, Switzerland.

Nicole A H Janssen (NAH)

National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands.
ORCID: 0000-0002-3117-5984

Klea Katsouyanni (K)

Dept of Hygiene, Epidemiology and Medical Statistics, Medical School, National and Kapodistrian University of Athens, Athens, Greece.

Matthias Ketzel (M)

Dept of Environmental Science, Aarhus University, Roskilde, Denmark.
Global Centre for Clean Air Research, University of Surrey, Guildford, UK.
ORCID: 0000-0001-9519-1935

Jochem O Klompmaker (JO)

Institute for Risk Assessment Sciences (IRAS), Utrecht University, Utrecht, The Netherlands.
National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands.

Gabriele Nagel (G)

Institute of Epidemiology and Medical Biometry, Ulm University, Ulm, Germany.

Bente Oftedal (B)

Dept of Environmental Health, Norwegian Institute of Public Health, Oslo, Norway.

Annette Peters (A)

Institute of Epidemiology, Helmholtz Zentrum München, Neuherberg, Germany.
Epidemiology, Faculty of Medicine, Ludwig Maximilians Universität München, Munich, Germany.

Anne Tjønneland (A)

Dept of Public Health, University of Copenhagen, Copenhagen, Denmark.
Danish Cancer Society Research Center, Copenhagen, Denmark.
ORCID: 0000-0003-4385-2097

Sophia P Rodopoulou (SP)

Dept of Hygiene, Epidemiology and Medical Statistics, Medical School, National and Kapodistrian University of Athens, Athens, Greece.

Evangelia Samoli (E)

Dept of Hygiene, Epidemiology and Medical Statistics, Medical School, National and Kapodistrian University of Athens, Athens, Greece.

Doris Tove Kristoffersen (DT)

Cluster for Health Services Research, Norwegian Institute of Public Health, Oslo, Norway.

Torben Sigsgaard (T)

Dept of Public Health, Environment Occupation and Health, Danish Ramazzini Centre, Aarhus University, Aarhus, Denmark.

Massimo Stafoggia (M)

Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Dept of Epidemiology, Lazio Regional Health Service, ASL Roma 1, Rome, Italy.

Danielle Vienneau (D)

Swiss Tropical and Public Health Institute, Basel, Switzerland.
ORCID: 0000-0002-6309-6439

Gudrun Weinmayr (G)

Institute of Epidemiology and Medical Biometry, Ulm University, Ulm, Germany.

Gerard Hoek (G)

Institute for Risk Assessment Sciences (IRAS), Utrecht University, Utrecht, The Netherlands.

Zorana Jovanovic Andersen (ZJ)

Dept of Public Health, University of Copenhagen, Copenhagen, Denmark zorana.andersen@sund.ku.dk.
Center for Epidemiological Research, Nykøbing F Hospital, Nykøbing F, Denmark.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Long-term exposure to low-level air pollution...
questionsmedicales.fr › Actions chimiques et utilisations › Actions toxiques › Polluants environnementaux › Polluants atmosphériques › Long-term exposure to low-level air pollution...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Pollution de l'environnement › Pollution de l'air › Long-term exposure to low-level air pollution...
questionsmedicales.fr › Maladies du système immunitaire › Hypersensibilité › Hypersensibilité immédiate › Hypersensibilité respiratoire › Asthme › Long-term exposure to low-level air pollution...
questionsmedicales.fr › Personnes › Tranches d'âge › Enfant › Long-term exposure to low-level air pollution...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Pollution de l'environnement › Exposition environnementale › Long-term exposure to low-level air pollution...
questionsmedicales.fr › Régions géographiques › Europe › Long-term exposure to low-level air pollution...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Long-term exposure to low-level air pollution...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Collecte de données › Registre civil › Morbidité › Incidence › Long-term exposure to low-level air pollution...
questionsmedicales.fr › Mélanges complexes › Matière particulaire › Long-term exposure to low-level air pollution...
questionsmedicales.fr › Régions géographiques › Europe › Pays nordiques et scandinaves › Suède › Long-term exposure to low-level air pollution...