Relative Strengths of Three Linearizations of Receptor Availability: Saturation, Inhibition, and Occupancy Plots.

Brain / metabolism Linear Models Positron-Emission Tomography / methods Radiopharmaceuticals / metabolism Tomography, X-Ray Computed
Lassen plots PET binding potential inhibition plot

Journal

Journal of nuclear medicine : official publication, Society of Nuclear Medicine
ISSN: 1535-5667
Titre abrégé: J Nucl Med
Pays: United States
ID NLM: 0217410

Informations de publication

Date de publication:
02 2022
Historique:
received: 15 12 2020
revised: 23 04 2021
pubmed: 6 6 2021
medline: 30 4 2022
entrez: 5 6 2021
Statut: ppublish

Résumé

We derived three widely used linearizations from the definition of receptor availability in molecular imaging with positron emission tomography (PET). The purpose of the present research was to determine the convergence of the results of the 3 methods in terms of 3 parameters-occupancy (s), distribution volume of the nondisplaceable reference binding compartment (V

Identifiants

DOI: 10.2967/jnumed.117.204453 PMID: 34088774 PMC: PMC8805780
pubmed: 34088774
pii: jnumed.117.204453
doi: 10.2967/jnumed.117.204453
pmc: PMC8805780
doi:

Substances chimiques

Radiopharmaceuticals 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

294-301

Informations de copyright

© 2022 by the Society of Nuclear Medicine and Molecular Imaging.

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Auteurs

Javad Khodaii (J)

Department of Mechanical Engineering, Amirkabir University of Technology, Tehran, Iran.
Research Center for Integrative Medicine in Aging, Aging Research Institute, Tabriz University of Medical Sciences, Tabriz, Iran.

Mostafa Araj-Khodaei (M)

Research Center for Integrative Medicine in Aging, Aging Research Institute, Tabriz University of Medical Sciences, Tabriz, Iran.

Manouchehr S Vafaee (MS)

BRIDGE (Brain Research Inter-Disciplinary Guided Excellence), Department of Clinical Research, University of Southern Denmark, Odense, Denmark.
Research Unit for Psychiatry, Southern Region, University of Southern Denmark, Odense, Denmark.
Department of Nuclear Medicine, Odense University Hospital, Odense, Denmark.

Dean F Wong (DF)

Mallinckrodt Institute of Radiology, Washington University, St. Louis, Missouri.

Albert Gjedde (A)

BRIDGE (Brain Research Inter-Disciplinary Guided Excellence), Department of Clinical Research, University of Southern Denmark, Odense, Denmark; albert.gjedde@clin.au.dk.
Department of Nuclear Medicine, Odense University Hospital, Odense, Denmark.
Translational Neuropsychiatry Unit, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.
Panum Institute, Department of Neuroscience, University of Copenhagen, Copenhagen, Denmark; and.
Neurosciences Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

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