Atypical Inflammatory Syndrome Triggered by SARS-CoV-2 in Infants with Down Syndrome.
COVID-19
Down syndrome
MIS-C
inborn errors of immunity
Journal
Journal of clinical immunology
ISSN: 1573-2592
Titre abrégé: J Clin Immunol
Pays: Netherlands
ID NLM: 8102137
Informations de publication
Date de publication:
10 2021
10 2021
Historique:
received:
19
03
2021
accepted:
25
05
2021
pubmed:
6
6
2021
medline:
28
9
2021
entrez:
5
6
2021
Statut:
ppublish
Résumé
While adults with Down syndrome (DS) are at increased risk of severe COVID-19 pneumonia, little is known about COVID-19 in children with DS. In children without DS, SARS-CoV-2 can rarely cause severe COVID-19 pneumonia, or an even rarer and more typically pediatric condition, multisystem inflammatory syndrome in children (MIS-C). Although the underlying mechanisms are still unknown, MIS-C is thought to be primarily immune-mediated. Here, we describe an atypical, severe form of MIS-C in two infant girls with DS who were hospitalized for over 4 months. Immunological evaluation revealed pronounced neutrophilia, B cell depletion, increased circulating IL-6 and IL-8, and elevated markers of immune activation ICAM1 and FcɣRI. Importantly, uninfected children with DS presented with similar but less stark immune features at steady state, possibly explaining risk of further uncontrolled inflammation following SARS-CoV-2 infection. Overall, a severe, atypical form of MIS-C may occur in children with DS.
Identifiants
pubmed: 34089457
doi: 10.1007/s10875-021-01078-4
pii: 10.1007/s10875-021-01078-4
pmc: PMC8178650
doi:
Types de publication
Case Reports
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
1457-1462Subventions
Organisme : NIAID NIH HHS
ID : T32 AI007647
Pays : United States
Organisme : NICHD NIH HHS
ID : T32 HD075735
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI150300
Pays : United States
Organisme : Eunice Kennedy Shriver National Institute of Child Health and Human Development
ID : T32HD075735
Organisme : National Institute of Allergy and Infectious Diseases
ID : R01AI150300
Informations de copyright
© 2021. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
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