Exercise training decreases intercostal and transversus abdominis muscle blood flows in heart failure rats during submaximal exercise.
Diaphragm
HFrEF
Respiratory muscle work
Journal
Respiratory physiology & neurobiology
ISSN: 1878-1519
Titre abrégé: Respir Physiol Neurobiol
Pays: Netherlands
ID NLM: 101140022
Informations de publication
Date de publication:
10 2021
10 2021
Historique:
received:
25
02
2021
revised:
18
05
2021
accepted:
02
06
2021
pubmed:
7
6
2021
medline:
21
1
2022
entrez:
6
6
2021
Statut:
ppublish
Résumé
Diaphragm muscle blood flow (BF) and vascular conductance (VC) are elevated with chronic heart failure (HF) during exercise. Exercise training (ExT) elicits beneficial respiratory muscle and pulmonary system adaptations in HF. We hypothesized that diaphragm BF and VC would be lower in HF rats following ExT than their sedentary counterparts (Sed). Respiratory muscle BFs and mean arterial pressure were measured via radiolabeled microspheres and carotid artery catheter, respectively, during submaximal treadmill exercise (20 m/min, 5 % grade). During exercise, no differences were present between HF + ExT and HF + Sed in diaphragm BFs (201 ± 36 vs. 227 ± 44 mL/min/100 g) or VCs (both, p > 0.05). HF + ExT compared to HF + Sed had lower intercostal BF (27 ± 3 vs. 41 ± 5 mL/min/100 g) and VC (0.21 ± 0.02 vs. 0.31 ± 0.04 mL/min/mmHg/100 g) during exercise (both, p < 0.05). Further, HF + ExT compared to HF + Sed had lower transversus abdominis BF (20 ± 1 vs. 35 ± 6 mL/min/100 g) and VC (0.14 ± 0.02 vs. 0.27 ± 0.05 mL/min/mmHg/100 g) during exercise (both, p < 0.05). These data suggest that exercise training lowers the intercostal and transversus abdominis BF responses in HF rats during submaximal treadmill exercise.
Identifiants
pubmed: 34091075
pii: S1569-9048(21)00095-1
doi: 10.1016/j.resp.2021.103710
pmc: PMC8319098
mid: NIHMS1713589
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
103710Subventions
Organisme : NICHD NIH HHS
ID : K12 HD065987
Pays : United States
Organisme : NIGMS NIH HHS
ID : P20 GM103466
Pays : United States
Organisme : NHLBI NIH HHS
ID : R15 HL108328
Pays : United States
Organisme : NHLBI NIH HHS
ID : T32 HL007111
Pays : United States
Informations de copyright
Copyright © 2021 Elsevier B.V. All rights reserved.
Références
J Physiol. 2010 Jul 1;588(Pt 13):2487-501
pubmed: 20457736
Exerc Sport Sci Rev. 2006 Oct;34(4):194-201
pubmed: 17031258
Physiol Rep. 2020 Jun;8(12):e14484
pubmed: 32562374
Circulation. 1992 Jun;85(6):2119-31
pubmed: 1591831
J Appl Physiol (1985). 1988 Aug;65(2):964-70
pubmed: 3139623
Respir Physiol Neurobiol. 2018 Jan;247:140-145
pubmed: 29037770
Can J Cardiol. 2017 Apr;33(4):508-514
pubmed: 28132741
Respir Physiol Neurobiol. 2019 May;263:26-30
pubmed: 30825527
Am J Physiol Heart Circ Physiol. 2012 Mar 1;302(5):H1050-63
pubmed: 22101528
Am J Physiol. 1992 Feb;262(2 Pt 2):H411-9
pubmed: 1539701
Respir Physiol Neurobiol. 2020 Oct;281:103518
pubmed: 32777269
Eur J Appl Physiol. 2012 Aug;112(8):3061-8
pubmed: 22194005
Am J Physiol Heart Circ Physiol. 2015 Nov;309(9):H1419-39
pubmed: 26320036
Cardiovasc Res. 2002 Dec;56(3):479-86
pubmed: 12445889
Am J Physiol. 1980 Oct;239(4):H443-H449
pubmed: 7425136
Exp Physiol. 2019 Jan;104(1):70-80
pubmed: 30298957
J Appl Physiol (1985). 2011 Dec;111(6):1664-70
pubmed: 21903877
Respir Physiol. 1995 Aug;101(2):171-82
pubmed: 8570919
J Appl Physiol (1985). 1997 Oct;83(4):1291-9
pubmed: 9338439
J Appl Physiol (1985). 2004 Nov;97(5):1866-73
pubmed: 15220300
Am J Physiol Heart Circ Physiol. 2008 Jun;294(6):H2465-72
pubmed: 18375714
Am J Physiol. 1993 Nov;265(5 Pt 2):H1721-6
pubmed: 8238585
Eur J Heart Fail. 2014 May;16(5):574-82
pubmed: 24634346
Circulation. 1989 Feb;79(2):324-9
pubmed: 2914350
Am J Physiol Heart Circ Physiol. 2010 Dec;299(6):H1755-61
pubmed: 20817826
J Appl Physiol (1985). 2017 Apr 1;122(4):918-924
pubmed: 28126910
J Appl Physiol (1985). 2012 Jan;112(1):127-34
pubmed: 21979803
J Physiol. 1961 Sep;158:1-14
pubmed: 13696595
Respir Physiol Neurobiol. 2017 Sep;243:20-26
pubmed: 28495570
J Appl Physiol (1985). 2000 Jan;88(1):186-94
pubmed: 10642380
Respir Physiol Neurobiol. 2016 Aug;230:54-9
pubmed: 27195511
Am Heart J. 2009 Nov;158(5):768.e1-7
pubmed: 19853695
Eur Respir J. 2012 Jun;39(6):1449-57
pubmed: 22034652
Nitric Oxide. 2018 Apr 1;74:1-9
pubmed: 29288804