Eosinophilic Granulomatosis with Polyangiitis Presenting with Central Retinal Artery Occlusion During Treatment with Anti-interleukin-5 Receptor Monoclonal Antibody.
anti-neutrophil cytoplasmic antibody
asthma
central retinal artery occlusion
eosinophilia
eosinophilic granulomatosis with polyangiitis
Journal
Internal medicine (Tokyo, Japan)
ISSN: 1349-7235
Titre abrégé: Intern Med
Pays: Japan
ID NLM: 9204241
Informations de publication
Date de publication:
15 Nov 2021
15 Nov 2021
Historique:
pubmed:
8
6
2021
medline:
17
11
2021
entrez:
7
6
2021
Statut:
ppublish
Résumé
Eosinophilic granulomatosis with polyangiitis (EGPA) is an anti-neutrophilic cytoplasm antibody (ANCA)-associated vasculitis characterized by asthma and eosinophilia. Although EGPA involves multiple organs, ocular involvement is infrequent and often carries a poor visual prognosis. We herein report a rare case of EGPA presenting with central retinal artery occlusion (CRAO) in which visual loss developed during treatment with anti-interleukin (IL)-5 receptor monoclonal antibody, and improvement in visual outcomes was attained after treatment combining high-dose oral corticosteroids, cyclophosphamide and an anticoagulant. Physicians should consider CRAO as an ophthalmic manifestation of EGPA in patients with severe eosinophilic asthma.
Identifiants
pubmed: 34092731
doi: 10.2169/internalmedicine.7027-21
pmc: PMC8666228
doi:
Substances chimiques
Antibodies, Monoclonal
0
Receptors, Interleukin-5
0
Types de publication
Case Reports
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
3631-3634Références
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