Low-Grade Endotoxemia and Thrombosis in COVID-19.
Biomarkers
/ blood
COVID-19
/ blood
Correlation of Data
Endotoxemia
/ diagnosis
Female
Fibrin Fibrinogen Degradation Products
/ analysis
Haptoglobins
/ metabolism
Humans
Intestinal Mucosa
/ metabolism
Lipopolysaccharides
/ analysis
Male
Middle Aged
Permeability
Pneumonia, Viral
/ diagnosis
Protein Precursors
/ metabolism
SARS-CoV-2
/ pathogenicity
Thrombosis
/ blood
Journal
Clinical and translational gastroenterology
ISSN: 2155-384X
Titre abrégé: Clin Transl Gastroenterol
Pays: United States
ID NLM: 101532142
Informations de publication
Date de publication:
04 06 2021
04 06 2021
Historique:
received:
21
09
2020
accepted:
12
03
2021
entrez:
7
6
2021
pubmed:
8
6
2021
medline:
22
6
2021
Statut:
epublish
Résumé
Patients with community-acquired pneumonia display enhanced levels of lipopolysaccharides (LPS) compared with controls, suggesting that low-grade endotoxemia may be implicated in vascular disturbances. It is unknown whether this occurs in patients with coronavirus 2019 (COVID-19) and its impact on thrombotic complications. We measured serum levels of zonulin, a marker of gut permeability, LPS, and D-dimer in 81 patients with COVID-19 and 81 healthy subjects; the occurrence of thrombotic events in COVID-19 during the intrahospital stay was registered. Serum LPS and zonulin were higher in patients with COVID-19 than in control subjects and, in COVID-19, significantly correlated (R = 0.513; P < 0.001). Among the 81 patients with COVID-19, 11 (14%) experienced thrombotic events in the arterial (n = 5) and venous circulation (n = 6) during a median follow-up of 18 days (interquartile range 11-27 days). A logistic regression analysis showed that LPS (P = 0.024) and D-dimer (P = 0.041) independently predicted thrombotic events. The study reports that low-grade endotoxemia is detectable in patients with COVID-19 and is associated with thrombotic events. The coexistence of low-grade endotoxemia with enhanced levels of zonulin may suggest enhanced gut permeability as an underlying mechanism.
Identifiants
pubmed: 34092777
doi: 10.14309/ctg.0000000000000348
pii: 01720094-202106000-00005
pmc: PMC8183715
doi:
Substances chimiques
Biomarkers
0
Fibrin Fibrinogen Degradation Products
0
Haptoglobins
0
Lipopolysaccharides
0
Protein Precursors
0
fibrin fragment D
0
zonulin
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e00348Commentaires et corrections
Type : CommentIn
Type : CommentIn
Informations de copyright
Copyright © 2021 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of The American College of Gastroenterology.
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