Von Willebrand Factor Facilitates Intravascular Dissemination of Microsporidia

Encephalitozoon hellem infection intravascular dissemination microsporidia von Willebrand factor

Journal

Frontiers in cellular and infection microbiology
ISSN: 2235-2988
Titre abrégé: Front Cell Infect Microbiol
Pays: Switzerland
ID NLM: 101585359

Informations de publication

Date de publication:
2021
Historique:
received: 14 04 2021
accepted: 04 05 2021
entrez: 7 6 2021
pubmed: 8 6 2021
medline: 6 7 2021
Statut: epublish

Résumé

Microsporidia are a group of spore-forming, fungus-related pathogens that can infect both invertebrates and vertebrates including humans. The primary infection site is usually digestive tract, but systemic infections occur as well and cause damages to organs such as lung, brain, and liver. The systemic spread of microsporidia may be intravascular, requiring attachment and colonization in the presence of shear stress. Von Willebrand Factor (VWF) is a large multimeric intravascular protein and the key attachment sites for platelets and coagulation factors. Here in this study, we investigated the interactions between VWF and microsporidia

Identifiants

pubmed: 34095003
doi: 10.3389/fcimb.2021.694957
pmc: PMC8176104
doi:

Substances chimiques

von Willebrand Factor 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

694957

Informations de copyright

Copyright © 2021 Bao, Mo, An, Luo, Poncz, Pan, Li and Zhou.

Déclaration de conflit d'intérêts

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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Auteurs

Jialing Bao (J)

State Key Laboratory of Silkworm Genome Biology, Southwest University, Chongqing, China.
Chongqing Key Laboratory of Microsporidia Infection and Control, Southwest University, Chongqing, China.

Biying Mo (B)

State Key Laboratory of Silkworm Genome Biology, Southwest University, Chongqing, China.
Chongqing Key Laboratory of Microsporidia Infection and Control, Southwest University, Chongqing, China.

Guozhen An (G)

State Key Laboratory of Silkworm Genome Biology, Southwest University, Chongqing, China.
Chongqing Key Laboratory of Microsporidia Infection and Control, Southwest University, Chongqing, China.

Jian Luo (J)

State Key Laboratory of Silkworm Genome Biology, Southwest University, Chongqing, China.
Chongqing Key Laboratory of Microsporidia Infection and Control, Southwest University, Chongqing, China.

Mortimer Poncz (M)

Department of Pediatrics, The Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States.

Guoqing Pan (G)

State Key Laboratory of Silkworm Genome Biology, Southwest University, Chongqing, China.
Chongqing Key Laboratory of Microsporidia Infection and Control, Southwest University, Chongqing, China.

Tian Li (T)

State Key Laboratory of Silkworm Genome Biology, Southwest University, Chongqing, China.
Chongqing Key Laboratory of Microsporidia Infection and Control, Southwest University, Chongqing, China.

Zeyang Zhou (Z)

State Key Laboratory of Silkworm Genome Biology, Southwest University, Chongqing, China.
Chongqing Key Laboratory of Microsporidia Infection and Control, Southwest University, Chongqing, China.
College of Life Sciences, Chongqing Normal University, Chongqing, China.

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