Single-marker and haplotype-based genome-wide association studies for the number of teats in two heavy pig breeds.
ARL4C
FRMD4A
HOXB1
Sus scrofa
VRTN
Landrace
Large White
morphological trait
single nucleotide polymorphism
Journal
Animal genetics
ISSN: 1365-2052
Titre abrégé: Anim Genet
Pays: England
ID NLM: 8605704
Informations de publication
Date de publication:
Aug 2021
Aug 2021
Historique:
accepted:
12
05
2021
pubmed:
8
6
2021
medline:
2
9
2021
entrez:
7
6
2021
Statut:
ppublish
Résumé
The number of teats is a reproductive-related trait of great economic relevance as it affects the mothering ability of the sows and thus the number of properly weaned piglets. Moreover, genetic improvement of this trait is fundamental to parallelly help the selection for increased litter size. We present the results of single-marker and haplotypes-based genome-wide association studies for the number of teats in two large cohorts of heavy pig breeds (Italian Large White and Italian Landrace) including 3990 animals genotyped with the 70K GGP Porcine BeadChip and other 1927 animals genotyped with the Illumina PorcineSNP60 BeadChip. In the Italian Large White population, genome scans identified three genome regions (SSC7, SSC10, and SSC12) that confirmed the involvement of the VRTN gene (as we previously reported) and highlighted additional loci known to affect teat counts, including the FRMD4A and HOXB1 gene regions. A different picture emerged in the Italian Landrace population, with a total of 12 genome regions in eight chromosomes (SSC3, SSC6, SSC8, SSC11, SSC13, SSC14, SSC15, and SSC16) mainly detected via the haplotype-based genome scan. The most relevant QTL was close to the ARL4C gene on SSC15. Markers in the VRTN gene region were not significant in the Italian Landrace breed. The use of both single-marker and haplotype-based genome-wide association analyses can be helpful to exploit and dissect the genome of the pigs of different populations. Overall, the obtained results supported the polygenic nature of the investigated trait and better elucidated its genetic architecture in Italian heavy pigs.
Identifiants
pubmed: 34096632
doi: 10.1111/age.13095
pmc: PMC8362157
doi:
Substances chimiques
Genetic Markers
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
440-450Subventions
Organisme : Università di Bologna
ID : RFO 2018-2019
Organisme : Ministero dell'Istruzione, dell'Università e della Ricerca
ID : PRIN2017 - PigPhenomics
Organisme : European Agricultural Fund for Rural Development
Organisme : Ministero delle Politiche Agricole Alimentari e Forestali
Organisme : Ministero degli Affari Esteri e della Cooperazione Internazionale
Informations de copyright
© 2021 The Authors. Animal Genetics published by John Wiley & Sons Ltd on behalf of Stichting International Foundation for Animal Genetics.
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