Diversity of Sequence Types and Impact of Fitness Cost among Carbapenem-Resistant Acinetobacter baumannii Isolates from Tripoli, Libya.

Acinetobacter Infections / drug therapy Acinetobacter baumannii / genetics Anti-Bacterial Agents / pharmacology Bacterial Proteins / genetics Carbapenems / pharmacology Humans Libya / epidemiology Microbial Sensitivity Tests Multilocus Sequence Typing beta-Lactamases / genetics
Acinetobacter baumannii antimicrobial resistance carbapenems fitness cost

Journal

Antimicrobial agents and chemotherapy
ISSN: 1098-6596
Titre abrégé: Antimicrob Agents Chemother
Pays: United States
ID NLM: 0315061

Informations de publication

Date de publication:
16 07 2021
Historique:
pubmed: 8 6 2021
medline: 10 8 2021
entrez: 7 6 2021
Statut: ppublish

Résumé

We investigated the molecular epidemiology of 21 carbapenem-resistant Acinetobacter baumannii isolates from Libya and assessed their relative fitness. Core genome multilocus sequence typing (MLST) revealed five interhospital transmission clusters. Three clusters were associated with the international clones (IC) IC1, IC2, and IC7. Carbapenem-resistance was associated with

Identifiants

DOI: 10.1128/AAC.00277-21 PMID: 34097495 PMC: PMC8373249
pubmed: 34097495
doi: 10.1128/AAC.00277-21
pmc: PMC8373249
doi:

Substances chimiques

Anti-Bacterial Agents 0
Bacterial Proteins 0
Carbapenems 0
beta-Lactamases EC 3.5.2.6

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

e0027721

Références

Biomed Res Int. 2016;2016:2475067
pubmed: 27274985
Clin Microbiol Infect. 2007 Dec;13(12):1199-201
pubmed: 17850345
J Clin Microbiol. 2006 Jul;44(7):2630-4
pubmed: 16825400
Eur J Epidemiol. 1992 Jan;8(1):9-14
pubmed: 1572437
Clin Infect Dis. 2008 Aug 15;47(4):439-43
pubmed: 18611162
Front Microbiol. 2016 Nov 01;7:1715
pubmed: 27847502
Int J Antimicrob Agents. 2016 Jun;47(6):430-5
pubmed: 27179815
Microb Drug Resist. 2015 Jun;21(3):335-41
pubmed: 25587875
Int J Antimicrob Agents. 2016 Jul;48(1):46-50
pubmed: 27216382
PLoS One. 2017 Jun 8;12(6):e0179228
pubmed: 28594944
Antimicrob Agents Chemother. 2012 Apr;56(4):1877-84
pubmed: 22290977
Indian J Med Microbiol. 2020 Jan-Mar;38(1):52-57
pubmed: 32719209
Clin Orthop Relat Res. 2008 Jun;466(6):1356-62
pubmed: 18347888
J Glob Antimicrob Resist. 2018 Jun;13:37-39
pubmed: 29530497
Clin Infect Dis. 2007 Jun 15;44(12):1577-84
pubmed: 17516401

Auteurs

Antoine G Abou Fayad (AG)

Department of Experimental Pathology, Immunology and Microbiology, Faculty of Medicine, American University of Beirut, Beirut, Lebanon.
Center for Infectious Diseases Research, American University of Beirut, Beirut, Lebanon.
World Health Organization (WHO) Collaborating Center for Reference and Research on Bacterial Pathogens, Beirut, Lebanon.

Louis-Patrick Haraoui (LP)

Department of Microbiology and Infectious Diseases, Faculty of Medicine and Health Sciences, Université de Sherbrooke, Sherbrooke, Quebec, Canada.

Ahmad Sleiman (A)

Department of Experimental Pathology, Immunology and Microbiology, Faculty of Medicine, American University of Beirut, Beirut, Lebanon.
Center for Infectious Diseases Research, American University of Beirut, Beirut, Lebanon.
World Health Organization (WHO) Collaborating Center for Reference and Research on Bacterial Pathogens, Beirut, Lebanon.

Mohamad Jaafar (M)

Department of Experimental Pathology, Immunology and Microbiology, Faculty of Medicine, American University of Beirut, Beirut, Lebanon.
Center for Infectious Diseases Research, American University of Beirut, Beirut, Lebanon.
World Health Organization (WHO) Collaborating Center for Reference and Research on Bacterial Pathogens, Beirut, Lebanon.

Abdulaziz Zorgani (A)

National Center for Disease Control Libya, Reference Laboratory, Tripoli, Libya.

Ghassan M Matar (GM)

Department of Experimental Pathology, Immunology and Microbiology, Faculty of Medicine, American University of Beirut, Beirut, Lebanon.
Center for Infectious Diseases Research, American University of Beirut, Beirut, Lebanon.
World Health Organization (WHO) Collaborating Center for Reference and Research on Bacterial Pathogens, Beirut, Lebanon.

Paul G Higgins (PG)

Institute for Medical Microbiology, Immunology and Hygiene, University of Cologne, Cologne, Germany.
German Centre for Infection Research (DZIF), Partner Site Bonn-Cologne, Cologne, Germany.

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Classifications MeSH

questionsmedicales.fr › Infection › Infections bactériennes et mycoses › Infections bactériennes › Infections bactériennes à Gram négatif › Infections à Moraxellaceae › Infections à Acinetobacter › Diversity of Sequence Types and Impact of...
questionsmedicales.fr › Bactéries › Proteobacteria › Gammaproteobacteria › Moraxellaceae › Acinetobacter › Acinetobacter baumannii › Diversity of Sequence Types and Impact of...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antibactériens › Diversity of Sequence Types and Impact of...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines bactériennes › Diversity of Sequence Types and Impact of...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › bêta-Lactames › Carbapénèmes › Diversity of Sequence Types and Impact of...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Diversity of Sequence Types and Impact of...
questionsmedicales.fr › Régions géographiques › Afrique › Afrique du Nord › Libye › Diversity of Sequence Types and Impact of...
questionsmedicales.fr › Techniques d'investigation › Évaluation préclinique de médicament › Tests de sensibilité microbienne › Diversity of Sequence Types and Impact of...
questionsmedicales.fr › Techniques d'investigation › Techniques génétiques › Analyse de séquence › Analyse de séquence d'ADN › Typage par séquençage multilocus › Diversity of Sequence Types and Impact of...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Amidohydrolases › bêta-Lactamases › Diversity of Sequence Types and Impact of...