Pulmonary Apical Cap as a Potential Risk Factor for Pleuroparenchymal Fibroelastosis.
Aged
Biopsy
/ methods
Cachexia
/ diagnosis
Coronary Artery Bypass
/ adverse effects
Diagnosis, Differential
Disease Progression
Dyspnea
/ diagnosis
Fatal Outcome
Humans
Intraoperative Complications
/ pathology
Long Term Adverse Effects
/ pathology
Lung
/ diagnostic imaging
Lung Diseases, Interstitial
/ etiology
Lung Injury
/ complications
Male
Pulmonary Fibrosis
/ etiology
Respiratory Function Tests
/ methods
Tomography, X-Ray Computed
/ methods
pleuroparenchymal fibroelastosis
pulmonary apical cap
Journal
Chest
ISSN: 1931-3543
Titre abrégé: Chest
Pays: United States
ID NLM: 0231335
Informations de publication
Date de publication:
06 2021
06 2021
Historique:
received:
09
09
2020
revised:
19
11
2020
accepted:
01
01
2021
entrez:
8
6
2021
pubmed:
9
6
2021
medline:
25
2
2023
Statut:
ppublish
Résumé
Pleuroparenchymal fibroelastosis (PPFE) is a progressive and frequently fatal interstitial lung disease that involves the upper lobes. Although its cause remains unknown, the histopathologic evidence underlying PPFE bears striking resemblance to that of the pulmonary apical cap (PAC), a relatively common and benign entity. We describe the case of a patient with PAC that evolved into distinctly asymmetric PPFE over 6 years after unilateral surgical lung injury. Given the histologic similarity between these two conditions, we propose that these two entities underlie common biologic pathways of abnormal response to lung injury, with the presence of a PAC increasing susceptibility to the development of PPFE in the face of ongoing inflammatory insults. This case describes the histopathologic evolution of PAC to PPFE before and after an inciting injury.
Identifiants
pubmed: 34099151
pii: S0012-3692(21)00038-6
doi: 10.1016/j.chest.2021.01.011
pii:
doi:
Types de publication
Case Reports
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e365-e370Informations de copyright
Copyright © 2021 American College of Chest Physicians. Published by Elsevier Inc. All rights reserved.