B cell signatures and tertiary lymphoid structures contribute to outcome in head and neck squamous cell carcinoma.

Analysis of Variance B-Lymphocytes / immunology CD4-Positive T-Lymphocytes CD8-Positive T-Lymphocytes / immunology Gene Expression Head and Neck Neoplasms / genetics Humans Immunotherapy / methods Papillomavirus Infections Semaphorins / genetics Squamous Cell Carcinoma of Head and Neck / genetics Survival Analysis T-Lymphocytes Tertiary Lymphoid Structures / metabolism

Journal

Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555

Informations de publication

Date de publication:
07 06 2021
Historique:
received: 13 05 2020
accepted: 21 04 2021
entrez: 8 6 2021
pubmed: 9 6 2021
medline: 23 6 2021
Statut: epublish

Résumé

Current immunotherapy paradigms aim to reinvigorate CD8

Identifiants

DOI: 10.1038/s41467-021-23355-x PMID: 34099645 PMC: PMC8184766
pubmed: 34099645
doi: 10.1038/s41467-021-23355-x
pii: 10.1038/s41467-021-23355-x
pmc: PMC8184766
doi:

Substances chimiques

SEMA4A protein, human 0
Semaphorins 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

3349

Subventions

Organisme : NIDCR NIH HHS
ID : R01 DE028343
Pays : United States
Organisme : NCI NIH HHS
ID : T32 CA082084
Pays : United States

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Auteurs

Ayana T Ruffin (AT)

Department of Immunology, University of Pittsburgh, Pittsburgh, PA, USA.
Tumor Microenvironment Center, Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA, USA.
Program in Microbiology and Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Hillman Cancer Center, Pittsburgh, PA, USA.

Anthony R Cillo (AR)

Department of Immunology, University of Pittsburgh, Pittsburgh, PA, USA.
Tumor Microenvironment Center, Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA, USA.
Hillman Cancer Center, Pittsburgh, PA, USA.
ORCID: 0000-0002-3213-3129

Tracy Tabib (T)

Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.

Angen Liu (A)

Department of Otolaryngology, University of Pittsburgh, Pittsburgh, PA, USA.

Sayali Onkar (S)

Department of Immunology, University of Pittsburgh, Pittsburgh, PA, USA.
Tumor Microenvironment Center, Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA, USA.
Program in Microbiology and Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Hillman Cancer Center, Pittsburgh, PA, USA.

Sheryl R Kunning (SR)

Department of Immunology, University of Pittsburgh, Pittsburgh, PA, USA.
Tumor Microenvironment Center, Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA, USA.
Hillman Cancer Center, Pittsburgh, PA, USA.

Caleb Lampenfeld (C)

Department of Immunology, University of Pittsburgh, Pittsburgh, PA, USA.
Tumor Microenvironment Center, Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA, USA.
Hillman Cancer Center, Pittsburgh, PA, USA.

Huda I Atiya (HI)

Hillman Cancer Center, Pittsburgh, PA, USA.
Division of Hematology and Oncology, Department of Medicine, Hillman Cancer Center, Pittsburgh, PA, USA.

Irina Abecassis (I)

Department of Immunology, University of Pittsburgh, Pittsburgh, PA, USA.
Tumor Microenvironment Center, Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA, USA.
Hillman Cancer Center, Pittsburgh, PA, USA.

Cornelius H L Kürten (CHL)

Department of Otorhinolaryngology, University Duisburg-Essen, Essen, Germany.
ORCID: 0000-0002-2720-0075

Zengbiao Qi (Z)

Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.

Ryan Soose (R)

Department of Otolaryngology, University of Pittsburgh, Pittsburgh, PA, USA.

Umamaheswar Duvvuri (U)

Hillman Cancer Center, Pittsburgh, PA, USA.
Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.

Seungwon Kim (S)

Department of Otolaryngology, University of Pittsburgh, Pittsburgh, PA, USA.

Steffi Oesterrich (S)

Hillman Cancer Center, Pittsburgh, PA, USA.
Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA, USA.
Women's Cancer Research Center, Magee-Womens Research Institute, University of Pittsburgh, Pittsburgh, PA, USA.
ORCID: 0000-0002-2537-6923

Robert Lafyatis (R)

Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
Department of Otolaryngology, University of Pittsburgh, Pittsburgh, PA, USA.

Lan G Coffman (LG)

Hillman Cancer Center, Pittsburgh, PA, USA.
Division of Hematology and Oncology, Department of Medicine, Hillman Cancer Center, Pittsburgh, PA, USA.
ORCID: 0000-0002-3753-1652

Robert L Ferris (RL)

Department of Immunology, University of Pittsburgh, Pittsburgh, PA, USA.
Tumor Microenvironment Center, Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA, USA.
Hillman Cancer Center, Pittsburgh, PA, USA.
Department of Otolaryngology, University of Pittsburgh, Pittsburgh, PA, USA.
Cancer Immunology and Immunotherapy Program, UPMC Hillman Cancer Center, Pittsburgh, PA, USA.

Dario A A Vignali (DAA)

Department of Immunology, University of Pittsburgh, Pittsburgh, PA, USA.
Tumor Microenvironment Center, Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA, USA.
Hillman Cancer Center, Pittsburgh, PA, USA.
Cancer Immunology and Immunotherapy Program, UPMC Hillman Cancer Center, Pittsburgh, PA, USA.
ORCID: 0000-0002-2771-5992

Tullia C Bruno (TC)

Department of Immunology, University of Pittsburgh, Pittsburgh, PA, USA. tbruno@pitt.edu.
Tumor Microenvironment Center, Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA, USA. tbruno@pitt.edu.
Hillman Cancer Center, Pittsburgh, PA, USA. tbruno@pitt.edu.
Cancer Immunology and Immunotherapy Program, UPMC Hillman Cancer Center, Pittsburgh, PA, USA. tbruno@pitt.edu.
ORCID: 0000-0002-6433-0207

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Classifications MeSH

questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Statistiques comme sujet › Analyse de variance › B cell signatures and tertiary lymphoid...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes B › B cell signatures and tertiary lymphoid...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Lymphocytes T CD4+ › B cell signatures and tertiary lymphoid...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Lymphocytes T CD8+ › B cell signatures and tertiary lymphoid...
questionsmedicales.fr › Phénomènes génétiques › Expression des gènes › B cell signatures and tertiary lymphoid...
questionsmedicales.fr › Tumeurs › Tumeurs par siège › Tumeurs de la tête et du cou › B cell signatures and tertiary lymphoid...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › B cell signatures and tertiary lymphoid...
questionsmedicales.fr › Thérapeutique › Biothérapie › Immunothérapie › B cell signatures and tertiary lymphoid...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Caractéristiques de la maladie › Maladies transmissibles › Maladies sexuellement transmissibles › Maladies sexuellement transmissibles virales › Infections à papillomavirus › B cell signatures and tertiary lymphoid...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Sémaphorines › B cell signatures and tertiary lymphoid...
questionsmedicales.fr › Tumeurs › Tumeurs par siège › Tumeurs de la tête et du cou › Carcinome épidermoïde de la tête et du cou › B cell signatures and tertiary lymphoid...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Statistiques comme sujet › Analyse de survie › B cell signatures and tertiary lymphoid...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › B cell signatures and tertiary lymphoid...
questionsmedicales.fr › États, signes et symptômes pathologiques › États anatomopathologiques › Structures lymphoïdes tertiaires › B cell signatures and tertiary lymphoid...