Probiotics ameliorate alveolar bone loss by regulating gut microbiota.
Alveolar Bone Loss
/ metabolism
Animals
Cytokines
/ blood
Down-Regulation
/ drug effects
Feces
/ chemistry
Female
Femur
/ diagnostic imaging
Gastrointestinal Microbiome
/ drug effects
Mandible
/ diagnostic imaging
Ovariectomy
Probiotics
/ pharmacology
Rats
Rats, Sprague-Dawley
T-Lymphocytes, Regulatory
/ cytology
Th17 Cells
/ cytology
X-Ray Microtomography
Th17 cell
Treg cell
alveolar bones
oestrogen deficiency
osteoimmunology
probiotics
Journal
Cell proliferation
ISSN: 1365-2184
Titre abrégé: Cell Prolif
Pays: England
ID NLM: 9105195
Informations de publication
Date de publication:
Jul 2021
Jul 2021
Historique:
revised:
16
04
2021
received:
08
02
2021
accepted:
15
05
2021
pubmed:
9
6
2021
medline:
13
7
2021
entrez:
8
6
2021
Statut:
ppublish
Résumé
Oestrogen deficiency is an aetiological factor of postmenopausal osteoporosis (PMO), which not only decreases bone density in vertebrae and long bone but also aggravates inflammatory alveolar bone loss. Recent evidence has suggested the critical role of gut microbiota in osteoimmunology and its influence on bone metabolisms. The present study aimed to evaluate the therapeutic effects of probiotics on alveolar bone loss under oestrogen-deficient condition. Inflammatory alveolar bone loss was established in ovariectomized (OVX) rats, and rats were daily intragastrically administered with probiotics until sacrifice. Gut microbiota composition, intestinal permeability, systemic immune status and alveolar bone loss were assessed to reveal the underlying correlation between gut microbiota and bone metabolisms. We found administration of probiotics significantly prevented inflammatory alveolar bone resorption in OVX rats. By enriching butyrate-producing genera and enhancing gut butyrate production, probiotics improved intestinal barrier and decreased gut permeability in the OVX rats. Furthermore, the oestrogen deprivation-induced inflammatory responses were suppressed in probiotics-treated OVX rats, as reflected by reduced serum levels of inflammatory cytokines and a balanced distribution of CD4 This study demonstrated that probiotics can effectively attenuate alveolar bone loss by modulating gut microbiota and further regulating osteoimmune response and thus represent a promising adjuvant in the treatment of alveolar bone loss under oestrogen deficiency.
Identifiants
pubmed: 34101283
doi: 10.1111/cpr.13075
pmc: PMC8249787
doi:
Substances chimiques
Cytokines
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e13075Subventions
Organisme : National Natural Science Foundation of China
ID : 81771099
Organisme : National Natural Science Foundation of China
ID : 81800989
Organisme : National Natural Science Foundation of China
ID : 81870754
Organisme : Science and Technology Department of Sichuan Province
ID : 2018SZ0121
Commentaires et corrections
Type : ErratumIn
Informations de copyright
© 2021 The Authors. Cell Proliferation published by John Wiley & Sons Ltd.
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