Impact of sex and

Adult Aged Aged, 80 and over Alzheimer Disease / complications Apolipoprotein E4 / genetics Cardiometabolic Risk Factors Cerebral Cortex / blood supply Cerebrovascular Circulation / genetics Cognitive Dysfunction / diagnosis Female Follow-Up Studies Genotype Humans Longitudinal Studies Magnetic Resonance Imaging / methods Male Middle Aged Sex Factors Spin Labels
APOE gene Alzheimer’s disease Cerebral perfusion cardiometabolic measurements chromosomal sex

Journal

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
ISSN: 1559-7016
Titre abrégé: J Cereb Blood Flow Metab
Pays: United States
ID NLM: 8112566

Informations de publication

Date de publication:
11 2021
Historique:
pubmed: 10 6 2021
medline: 18 12 2021
entrez: 9 6 2021
Statut: ppublish

Résumé

Cerebral hypoperfusion is thought to contribute to cognitive decline in Alzheimer's disease, but the natural trajectory of cerebral perfusion in cognitively healthy adults has not been well-studied. This longitudinal study is consisted of 950 participants (40-89 years), who were cognitively unimpaired at their first visit. We investigated the age-related changes in cerebral perfusion, and their associations with

Identifiants

DOI: 10.1177/0271678X211021313 PMID: 34102919 PMC: PMC8545048
pubmed: 34102919
doi: 10.1177/0271678X211021313
pmc: PMC8545048
doi:

Substances chimiques

Apolipoprotein E4 0
Spin Labels 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

Langues

eng

Sous-ensembles de citation

IM

Pagination

3016-3027

Subventions

Organisme : NIA NIH HHS
ID : R01 AG037639
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG062167
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG027161
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR002373
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG062715
Pays : United States
Organisme : NCATS NIH HHS
ID : KL2 TR002374
Pays : United States
Organisme : NIA NIH HHS
ID : P50 AG033514
Pays : United States
Organisme : NCRR NIH HHS
ID : UL1 RR025011
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG021155
Pays : United States

Références

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Auteurs

Rui Wang (R)

Wisconsin Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
The Swedish School of Sport and Health Science, GIH, Stockholm, Sweden.
Division of Clinical Geriatrics, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm, Sweden.
ORCID: 0000-0001-7209-741X

Jennifer M Oh (JM)

Wisconsin Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
Geriatric Research Education and Clinical Center, William S. Middleton Memorial Veterans Hospital, Madison, WI, USA.

Alice Motovylyak (A)

Wisconsin Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.

Yue Ma (Y)

Wisconsin Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.

Mark A Sager (MA)

Wisconsin Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
Wisconsin Alzheimer's Institute, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.

Howard A Rowley (HA)

Wisconsin Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
Department of Radiology, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.

Kevin M Johnson (KM)

Department of Medical Physics, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.

Catherine L Gallagher (CL)

Wisconsin Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
Geriatric Research Education and Clinical Center, William S. Middleton Memorial Veterans Hospital, Madison, WI, USA.

Cynthia M Carlsson (CM)

Wisconsin Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
Geriatric Research Education and Clinical Center, William S. Middleton Memorial Veterans Hospital, Madison, WI, USA.

Barbara B Bendlin (BB)

Wisconsin Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
Geriatric Research Education and Clinical Center, William S. Middleton Memorial Veterans Hospital, Madison, WI, USA.
Wisconsin Alzheimer's Institute, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.

Sterling C Johnson (SC)

Wisconsin Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
Geriatric Research Education and Clinical Center, William S. Middleton Memorial Veterans Hospital, Madison, WI, USA.
Wisconsin Alzheimer's Institute, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.

Sanjay Asthana (S)

Wisconsin Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
Geriatric Research Education and Clinical Center, William S. Middleton Memorial Veterans Hospital, Madison, WI, USA.

Laura Eisenmenger (L)

Wisconsin Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
Department of Radiology, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.

Ozioma C Okonkwo (OC)

Wisconsin Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
Geriatric Research Education and Clinical Center, William S. Middleton Memorial Veterans Hospital, Madison, WI, USA.
Wisconsin Alzheimer's Institute, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Impact of sex and
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Impact of sex and
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Sujet âgé de 80 ans ou plus › Impact of sex and
questionsmedicales.fr › Troubles mentaux › Troubles neurocognitifs › Démence › Maladie d'Alzheimer › Impact of sex and
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Lipoprotéines › Apolipoprotéines › Apolipoprotéines E › Apolipoprotéine E4 › Impact of sex and
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Statistiques comme sujet › Probabilité › Risque › Facteurs de risque › Facteurs de risque de maladie cardiaque › Facteurs de risque cardiométabolique › Impact of sex and
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Prosencéphale › Télencéphale › Cerveau › Cortex cérébral › Impact of sex and
questionsmedicales.fr › Phénomènes physiologiques respiratoires et circulatoires › Phénomènes physiologiques cardiovasculaires › Circulation sanguine › Circulation cérébrovasculaire › Impact of sex and
questionsmedicales.fr › Troubles mentaux › Troubles neurocognitifs › Troubles de la cognition › Dysfonctionnement cognitif › Impact of sex and
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Études de suivi › Impact of sex and
questionsmedicales.fr › Phénomènes génétiques › Génotype › Impact of sex and
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Impact of sex and
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Études longitudinales › Impact of sex and
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Imagerie diagnostique › Tomographie › Imagerie par résonance magnétique › Impact of sex and
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › Impact of sex and
questionsmedicales.fr › Environnement et santé publique › Santé publique › Facteurs épidémiologiques › Facteurs sexuels › Impact of sex and
questionsmedicales.fr › Composés chimiques organiques › Radicaux libres › Marqueurs de spin › Impact of sex and