Alcohol intake and total mortality in 142 960 individuals from the MORGAM Project: a population-based study.
Alcohol intake
HDL cholesterol
cancer mortality
cardiovascular mortality
cohort study
mortality
Journal
Addiction (Abingdon, England)
ISSN: 1360-0443
Titre abrégé: Addiction
Pays: England
ID NLM: 9304118
Informations de publication
Date de publication:
02 2022
02 2022
Historique:
revised:
02
11
2020
received:
19
07
2020
accepted:
26
05
2021
pubmed:
10
6
2021
medline:
2
2
2022
entrez:
9
6
2021
Statut:
ppublish
Résumé
To test the association of alcohol consumption with total and cause-specific mortality risk. Prospective observational multi-centre population-based study. Sixteen cohorts (15 from Europe) in the MOnica Risk, Genetics, Archiving and Monograph (MORGAM) Project. A total of 142 960 individuals (mean age 50 ± 13 years, 53.9% men). Average alcohol intake by food frequency questionnaire, total and cause-specific mortality. In comparison with life-time abstainers, consumption of alcohol less than 10 g/day was associated with an average 11% [95% confidence interval (CI) = 7-14%] reduction in the risk of total mortality, while intake > 20 g/day was associated with a 13% (95% CI = 7-20%) increase in the risk of total mortality. Comparable findings were observed for cardiovascular (CV) deaths. With regard to cancer, drinking up to 10 g/day was not associated with either mortality risk reduction or increase, while alcohol intake > 20 g/day was associated with a 22% (95% CI = 10-35%) increased risk of mortality. The association of alcohol with fatal outcomes was similar in men and women, differed somewhat between countries and was more apparent in individuals preferring wine, suggesting that benefits may not be due to ethanol but other ingredients. Mediation analysis showed that high-density lipoprotein cholesterol explained 2.9 and 18.7% of the association between low alcohol intake and total as well as CV mortality, respectively. In comparison with life-time abstainers, consuming less than one drink per day (nadir at 5 g/day) was associated with a reduced risk of total, cardiovascular and other causes mortality, except cancer. Intake of more than two drinks per day was associated with an increased risk of total, cardiovascular and especially cancer mortality.
Substances chimiques
Cholesterol, HDL
0
Types de publication
Journal Article
Multicenter Study
Observational Study
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
312-325Subventions
Organisme : Medical Research Council
ID : G0601463
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/K023241/1
Pays : United Kingdom
Organisme : Medical Research Council London
ID : G0601463 (80983)
Commentaires et corrections
Type : CommentIn
Type : CommentIn
Type : CommentIn
Informations de copyright
© 2021 The Authors. Addiction published by John Wiley & Sons Ltd on behalf of Society for the Study of Addiction.
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