Redefining IL11 as a regeneration-limiting hepatotoxin and therapeutic target in acetaminophen-induced liver injury.

Acetaminophen / toxicity Animals Chemical and Drug Induced Liver Injury / drug therapy Chemical and Drug Induced Liver Injury, Chronic Hepatocytes Interleukin-11 Interleukin-11 Receptor alpha Subunit Liver Mice Mice, Inbred C57BL

Journal

Science translational medicine
ISSN: 1946-6242
Titre abrégé: Sci Transl Med
Pays: United States
ID NLM: 101505086

Informations de publication

Date de publication:
09 06 2021
Historique:
received: 07 01 2020
revised: 18 12 2020
accepted: 02 04 2021
entrez: 10 6 2021
pubmed: 11 6 2021
medline: 13 7 2021
Statut: ppublish

Résumé

Acetaminophen (

Identifiants

DOI: 10.1126/scitranslmed.aba8146 PMID: 34108253
pubmed: 34108253
pii: 13/597/eaba8146
doi: 10.1126/scitranslmed.aba8146
pii:
doi:

Substances chimiques

Il11ra1 protein, mouse 0
Interleukin-11 0
Interleukin-11 Receptor alpha Subunit 0
Acetaminophen 362O9ITL9D

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : Medical Research Council
ID : MC_U120085815
Pays : United Kingdom

Commentaires et corrections

Type : CommentIn

Informations de copyright

Copyright © 2021 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.

Auteurs

Anissa A Widjaja (AA)

Cardiovascular and Metabolic Disorders Program, Duke-National University of Singapore Medical School, Singapore 169857, Singapore. stuart.cook@duke-nus.edu.sg anissa.widjaja@duke-nus.edu.sg.
ORCID: 0000-0001-9404-7608

Jinrui Dong (J)

Cardiovascular and Metabolic Disorders Program, Duke-National University of Singapore Medical School, Singapore 169857, Singapore.
ORCID: 0000-0001-8858-0078

Eleonora Adami (E)

Cardiovascular and Metabolic Disorders Program, Duke-National University of Singapore Medical School, Singapore 169857, Singapore.

Sivakumar Viswanathan (S)

Cardiovascular and Metabolic Disorders Program, Duke-National University of Singapore Medical School, Singapore 169857, Singapore.
ORCID: 0000-0002-9263-1656

Benjamin Ng (B)

Cardiovascular and Metabolic Disorders Program, Duke-National University of Singapore Medical School, Singapore 169857, Singapore.
National Heart Research Institute Singapore, National Heart Centre Singapore, Singapore 169609, Singapore.
ORCID: 0000-0001-8970-0932

Leroy S Pakkiri (LS)

Cardiac Department, National University Hospital, Singapore 119074, Singapore.

Sonia P Chothani (SP)

Cardiovascular and Metabolic Disorders Program, Duke-National University of Singapore Medical School, Singapore 169857, Singapore.

Brijesh K Singh (BK)

Cardiovascular and Metabolic Disorders Program, Duke-National University of Singapore Medical School, Singapore 169857, Singapore.
ORCID: 0000-0003-4615-3988

Wei Wen Lim (WW)

National Heart Research Institute Singapore, National Heart Centre Singapore, Singapore 169609, Singapore.
ORCID: 0000-0003-0311-943X

Jin Zhou (J)

Cardiovascular and Metabolic Disorders Program, Duke-National University of Singapore Medical School, Singapore 169857, Singapore.

Shamini G Shekeran (SG)

Cardiovascular and Metabolic Disorders Program, Duke-National University of Singapore Medical School, Singapore 169857, Singapore.

Jessie Tan (J)

Cardiovascular and Metabolic Disorders Program, Duke-National University of Singapore Medical School, Singapore 169857, Singapore.
National Heart Research Institute Singapore, National Heart Centre Singapore, Singapore 169609, Singapore.

Sze Yun Lim (SY)

National Heart Research Institute Singapore, National Heart Centre Singapore, Singapore 169609, Singapore.
ORCID: 0000-0002-4921-3555

Joyce Goh (J)

Cardiovascular and Metabolic Disorders Program, Duke-National University of Singapore Medical School, Singapore 169857, Singapore.

Mao Wang (M)

Cardiovascular and Metabolic Disorders Program, Duke-National University of Singapore Medical School, Singapore 169857, Singapore.
ORCID: 0000-0001-7545-4048

Robert Holgate (R)

Abzena, Babraham Research Campus, Babraham, Cambridge CB22 3AT, UK.

Arron Hearn (A)

Abzena, Babraham Research Campus, Babraham, Cambridge CB22 3AT, UK.
ORCID: 0000-0002-1237-9359

Leanne E Felkin (LE)

National Heart and Lung Institute, Imperial College London, London SW3 6LY, UK.
ORCID: 0000-0003-1402-8314

Paul M Yen (PM)

Cardiovascular and Metabolic Disorders Program, Duke-National University of Singapore Medical School, Singapore 169857, Singapore.

James W Dear (JW)

Pharmacology, Toxicology and Therapeutics, Centre for Cardiovascular Science, University of Edinburgh, Edinburgh EH16 4TJ, UK.
ORCID: 0000-0002-8630-8625

Chester L Drum (CL)

Cardiovascular Research Institute, National University Health System, Singapore 119228, Singapore.
Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore.
Department of Surgery, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore.
ORCID: 0000-0001-6327-4584

Sebastian Schafer (S)

Cardiovascular and Metabolic Disorders Program, Duke-National University of Singapore Medical School, Singapore 169857, Singapore.
National Heart Research Institute Singapore, National Heart Centre Singapore, Singapore 169609, Singapore.

Stuart A Cook (SA)

Cardiovascular and Metabolic Disorders Program, Duke-National University of Singapore Medical School, Singapore 169857, Singapore. stuart.cook@duke-nus.edu.sg anissa.widjaja@duke-nus.edu.sg.
National Heart Research Institute Singapore, National Heart Centre Singapore, Singapore 169609, Singapore.
MRC-London Institute of Medical Sciences, Hammersmith Hospital Campus, London W12 0NN, UK.
ORCID: 0000-0001-6628-194X

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Classifications MeSH

questionsmedicales.fr › Composés chimiques organiques › Amines › Dérivés de l'aniline › Anilides › Acétanilides › Acétaminophène › Redefining IL11 as a regeneration-limiting...
questionsmedicales.fr › Eucaryotes › Animaux › Redefining IL11 as a regeneration-limiting...
questionsmedicales.fr › Troubles dus à des produits chimiques › Intoxication › Lésions hépatiques dues aux substances › Redefining IL11 as a regeneration-limiting...
questionsmedicales.fr › Troubles dus à des produits chimiques › Intoxication › Lésions hépatiques dues aux substances › Lésions hépatiques chroniques d'origine chimique ou médicamenteuse › Redefining IL11 as a regeneration-limiting...
questionsmedicales.fr › Cellules › Cellules épithéliales › Hépatocytes › Redefining IL11 as a regeneration-limiting...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Interleukines › Interleukine-11 › Redefining IL11 as a regeneration-limiting...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs immunologiques › Récepteurs aux cytokines › Récepteurs aux interleukines › Récepteurs à l'interleukine-11 › Sous-unité alpha du récepteur à l'interleukine-11 › Redefining IL11 as a regeneration-limiting...
questionsmedicales.fr › Système digestif › Foie › Redefining IL11 as a regeneration-limiting...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Redefining IL11 as a regeneration-limiting...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › Redefining IL11 as a regeneration-limiting...