Brain network dynamics during working memory are modulated by dopamine and diminished in schizophrenia.
Adult
Brain
/ diagnostic imaging
Dopamine D2 Receptor Antagonists
/ pharmacology
Female
Humans
Magnetic Resonance Imaging
Male
Memory, Short-Term
/ drug effects
Middle Aged
Nerve Net
/ diagnostic imaging
Prefrontal Cortex
/ diagnostic imaging
Receptors, Dopamine D1
/ genetics
Receptors, Dopamine D2
/ genetics
Schizophrenia
/ diagnostic imaging
Young Adult
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
09 06 2021
09 06 2021
Historique:
received:
26
10
2019
accepted:
27
04
2021
entrez:
10
6
2021
pubmed:
11
6
2021
medline:
23
6
2021
Statut:
epublish
Résumé
Dynamical brain state transitions are critical for flexible working memory but the network mechanisms are incompletely understood. Here, we show that working memory performance entails brain-wide switching between activity states using a combination of functional magnetic resonance imaging in healthy controls and individuals with schizophrenia, pharmacological fMRI, genetic analyses and network control theory. The stability of states relates to dopamine D1 receptor gene expression while state transitions are influenced by D2 receptor expression and pharmacological modulation. Individuals with schizophrenia show altered network control properties, including a more diverse energy landscape and decreased stability of working memory representations. Our results demonstrate the relevance of dopamine signaling for the steering of whole-brain network dynamics during working memory and link these processes to schizophrenia pathophysiology.
Identifiants
pubmed: 34108456
doi: 10.1038/s41467-021-23694-9
pii: 10.1038/s41467-021-23694-9
pmc: PMC8190281
doi:
Substances chimiques
DRD1 protein, human
0
DRD2 protein, human
0
Dopamine D2 Receptor Antagonists
0
Receptors, Dopamine D1
0
Receptors, Dopamine D2
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
3478Subventions
Organisme : NIMH NIH HHS
ID : R01 MH107235
Pays : United States
Organisme : NIDCD NIH HHS
ID : R01 DC009209
Pays : United States
Organisme : NIMH NIH HHS
ID : R21 MH106799
Pays : United States
Organisme : NICHD NIH HHS
ID : R01 HD086888
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH107703
Pays : United States
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