Silicon, an important exposure marker in vivo in silicosis research.
Administration, Inhalation
Adult
Aged
Animals
Humans
Inhalation Exposure
Iron
Lung
/ drug effects
Male
Middle Aged
Mining
Occupational Exposure
Pulmonary Surfactant-Associated Protein D
/ blood
Rats, Wistar
Silicon
/ blood
Silicon Dioxide
/ administration & dosage
Silicosis
/ blood
Transforming Growth Factor beta1
/ blood
Tumor Necrosis Factor-alpha
/ blood
Uteroglobin
/ blood
CC16
SP-D
Silicon
Silicosis
TGF-β1
TNF-α
Journal
International archives of occupational and environmental health
ISSN: 1432-1246
Titre abrégé: Int Arch Occup Environ Health
Pays: Germany
ID NLM: 7512134
Informations de publication
Date de publication:
Oct 2021
Oct 2021
Historique:
received:
29
07
2019
accepted:
27
03
2021
pubmed:
11
6
2021
medline:
24
9
2021
entrez:
10
6
2021
Statut:
ppublish
Résumé
The degree of silicosis exposure is closely related to the progress of silicosis. At present, we use animal and human studies to explore whether silicon can be an important exposure marker in the development of silicosis. Rats were randomly divided into 2 groups: (1) controls; and (2) silicosis. Rats in the silicosis group were killed at 4, 8, 12, 16, 24 h, 3, 7, 14, 21, and 28 days. Hematoxylin-eosin (HE) and immunohistochemistry (IHC) were performed to observe the histomorphology of lung tissue. The expression levels of CC16 and SP-D were detected using ELISA kits. In addition, we conducted a population study. Workers who have been selected to work in an iron mine for more than 1 year as research objects. The population was divided into four groups: silicosis exposure group (workers exposed to silica dust for more than 1 year in an iron mine were selected); patients group (silicosis patients); observation group (evidence of disease not meeting formal diagnostic criteria) and control group. Both the levels of trace silicon in the urine and blood of rats and human subjects were measured with ICP-MS. Serum levels of silicon were immediately increased in rats exposed to silicon dust. Similarly, our population study revealed that the silicon level in the silica exposure group and the observing group (exposed but no obvious symptoms) were significantly increased over that of the control group (P < 0.05). In subjects with extended exposure to silica, the serum and urine silicon level in exposed workers appeared to rapidly increase, reaching its peak in 1-5 years, followed by a gradual decline thereafter. Workers exposed to dust for less than 10 years were divided into subgroups by 2-year limit. The levels of serum silicon, urine silicon, TGF-β1, and TNF-α were significantly higher than that of control group. Changes of the serum levels of silicon occurred earlier than the expression of cytokines such as TNF-α, TGF-β
Identifiants
pubmed: 34110461
doi: 10.1007/s00420-021-01729-4
pii: 10.1007/s00420-021-01729-4
doi:
Substances chimiques
Pulmonary Surfactant-Associated Protein D
0
Scgb1a1 protein, rat
0
Transforming Growth Factor beta1
0
Tumor Necrosis Factor-alpha
0
Silicon Dioxide
7631-86-9
Uteroglobin
9060-09-7
Iron
E1UOL152H7
Silicon
Z4152N8IUI
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1513-1522Subventions
Organisme : National Natural Science Foundation of China
ID : 81673119
Organisme : National Natural Science Foundation of China
ID : 81602814
Organisme : Natural Science Foundation of Hebei Province
ID : H2018209337
Organisme : Hebei Provincial Key Research and Development Project (CN)
ID : 192777129D
Organisme : Science and Technology Research Project of Colleges and Universities in Hebei Province
ID : ZD2016026
Informations de copyright
© 2021. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
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