Impaired Binding to Junctophilin-2 and Nanostructural Alteration in CPVT Mutation.

Action Potentials Animals Binding Sites Calcium Signaling Cells, Cultured HEK293 Cells Humans Membrane Proteins / metabolism Mice Mice, Inbred C57BL Mutation Myocytes, Cardiac / metabolism Protein Binding Ryanodine Receptor Calcium Release Channel / chemistry Tachycardia, Ventricular / genetics
action potential calcium junctophilin mutation ryanodine receptor ventricular tachycardia

Journal

Circulation research
ISSN: 1524-4571
Titre abrégé: Circ Res
Pays: United States
ID NLM: 0047103

Informations de publication

Date de publication:
23 07 2021
Historique:
pubmed: 12 6 2021
medline: 11 1 2022
entrez: 11 6 2021
Statut: ppublish

Résumé

[Figure: see text].

Identifiants

DOI: 10.1161/CIRCRESAHA.121.319094 PMID: 34111951 PMC: PMC8320243
pubmed: 34111951
doi: 10.1161/CIRCRESAHA.121.319094
pmc: PMC8320243
mid: NIHMS1714619
doi:

Substances chimiques

Membrane Proteins 0
RyR2 protein, human 0
Ryanodine Receptor Calcium Release Channel 0
junctophilin 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

e35-e52

Subventions

Organisme : NIGMS NIH HHS
ID : R01 GM111397
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL055438
Pays : United States
Organisme : British Heart Foundation
ID : FS/15/30/31494
Pays : United Kingdom

Commentaires et corrections

Type : CommentIn

Références

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Auteurs

Liheng Yin (L)

Signaling and Cardiovascular Pathophysiology - UMR-S 1180, Inserm, Université Paris-Saclay 92296 Châtenay-Malabry, France (L.Y., A.Z., R.R., P.J., E.M.-S., O.V., L.L., Y.Y.W., P.M., P.G., R.P., J.L.A., J.-P.B., A.M.G.).

Alexandra Zahradnikova (A)

Signaling and Cardiovascular Pathophysiology - UMR-S 1180, Inserm, Université Paris-Saclay 92296 Châtenay-Malabry, France (L.Y., A.Z., R.R., P.J., E.M.-S., O.V., L.L., Y.Y.W., P.M., P.G., R.P., J.L.A., J.-P.B., A.M.G.).

Riccardo Rizzetto (R)

Signaling and Cardiovascular Pathophysiology - UMR-S 1180, Inserm, Université Paris-Saclay 92296 Châtenay-Malabry, France (L.Y., A.Z., R.R., P.J., E.M.-S., O.V., L.L., Y.Y.W., P.M., P.G., R.P., J.L.A., J.-P.B., A.M.G.).

Simona Boncompagni (S)

CAST, Department of Neuroscience, Imaging and Clinical Sciences (DNICS), Medicine and Ageing Sciences (DMSI), University Gabriele d'Annunzio, Chieti, Italy (S.B., F.P.).

Camille Rabesahala de Meritens (C)

Swansea University Medical School, Institute of Life Science, Swansea, SA2 8PP, UK (C.R.d.M., Y.Z., S.Z.).

Yadan Zhang (Y)

Swansea University Medical School, Institute of Life Science, Swansea, SA2 8PP, UK (C.R.d.M., Y.Z., S.Z.).

Pierre Joanne (P)

Signaling and Cardiovascular Pathophysiology - UMR-S 1180, Inserm, Université Paris-Saclay 92296 Châtenay-Malabry, France (L.Y., A.Z., R.R., P.J., E.M.-S., O.V., L.L., Y.Y.W., P.M., P.G., R.P., J.L.A., J.-P.B., A.M.G.).

Elena Marqués-Sulé (E)

Signaling and Cardiovascular Pathophysiology - UMR-S 1180, Inserm, Université Paris-Saclay 92296 Châtenay-Malabry, France (L.Y., A.Z., R.R., P.J., E.M.-S., O.V., L.L., Y.Y.W., P.M., P.G., R.P., J.L.A., J.-P.B., A.M.G.).
Physiotherapy, University of Valencia, Valencia, Spain (E.M.-S.).

Yuriana Aguilar-Sánchez (Y)

Physiology and Biophysics, Rush University Medical Center, Chicago, IL, USA (Y.A.-S., J.R.-F.).

Miguel Fernández-Tenorio (M)

Physiology, University of Bern, Bern, Switzerland (M.F.-T., E.N.).

Olivier Villejoubert (O)

Signaling and Cardiovascular Pathophysiology - UMR-S 1180, Inserm, Université Paris-Saclay 92296 Châtenay-Malabry, France (L.Y., A.Z., R.R., P.J., E.M.-S., O.V., L.L., Y.Y.W., P.M., P.G., R.P., J.L.A., J.-P.B., A.M.G.).

Linwei Li (L)

Signaling and Cardiovascular Pathophysiology - UMR-S 1180, Inserm, Université Paris-Saclay 92296 Châtenay-Malabry, France (L.Y., A.Z., R.R., P.J., E.M.-S., O.V., L.L., Y.Y.W., P.M., P.G., R.P., J.L.A., J.-P.B., A.M.G.).

Yue Yi Wang (YY)

Signaling and Cardiovascular Pathophysiology - UMR-S 1180, Inserm, Université Paris-Saclay 92296 Châtenay-Malabry, France (L.Y., A.Z., R.R., P.J., E.M.-S., O.V., L.L., Y.Y.W., P.M., P.G., R.P., J.L.A., J.-P.B., A.M.G.).

Philippe Mateo (P)

Signaling and Cardiovascular Pathophysiology - UMR-S 1180, Inserm, Université Paris-Saclay 92296 Châtenay-Malabry, France (L.Y., A.Z., R.R., P.J., E.M.-S., O.V., L.L., Y.Y.W., P.M., P.G., R.P., J.L.A., J.-P.B., A.M.G.).

Valérie Nicolas (V)

IPSIT, 92296 Châtenay-Malabry, France (V.N.).

Pascale Gerbaud (P)

Signaling and Cardiovascular Pathophysiology - UMR-S 1180, Inserm, Université Paris-Saclay 92296 Châtenay-Malabry, France (L.Y., A.Z., R.R., P.J., E.M.-S., O.V., L.L., Y.Y.W., P.M., P.G., R.P., J.L.A., J.-P.B., A.M.G.).

F Anthony Lai (FA)

College of Medicine, Biomedical & Pharmaceutical Research Unit, QU Health, & Biomedical Research Centre, Qatar University, Doha, Qatar (F.A.L.).

Romain Perrier (R)

Julio L Álvarez (JL)

Signaling and Cardiovascular Pathophysiology - UMR-S 1180, Inserm, Université Paris-Saclay 92296 Châtenay-Malabry, France (L.Y., A.Z., R.R., P.J., E.M.-S., O.V., L.L., Y.Y.W., P.M., P.G., R.P., J.L.A., J.-P.B., A.M.G.).
Institute of Cardiology, Havana, Cuba (J.L.A.).

Ernst Niggli (E)

Physiology, University of Bern, Bern, Switzerland (M.F.-T., E.N.).

Héctor H Valdivia (HH)

Medicine and Cardiovascular Research Center, University of Wisconsin-Madison School of Medicine and Public Health, Madison, Wisconsin (H.H.V., C.R.V.).

Carmen R Valdivia (CR)

Medicine and Cardiovascular Research Center, University of Wisconsin-Madison School of Medicine and Public Health, Madison, Wisconsin (H.H.V., C.R.V.).

Josefina Ramos-Franco (J)

Physiology and Biophysics, Rush University Medical Center, Chicago, IL, USA (Y.A.-S., J.R.-F.).

Esther Zorio (E)

Cardiology Department and Unidad de Cardiopatías Familiares, Muerte Súbita y Mecanismos de Enfermedad (CaFaMuSMe), Hospital Universitario y Politécnico La Fe and Instituto de Investigación Sanitaria La Fe, Valencia, Spain (E.Z.).
Center for Biomedical Network Research on Cardiovascular diseases (CIBERCV), Madrid, Spain (E.Z.).

Spyros Zissimopoulos (S)

Swansea University Medical School, Institute of Life Science, Swansea, SA2 8PP, UK (C.R.d.M., Y.Z., S.Z.).

Feliciano Protasi (F)

CAST, Department of Neuroscience, Imaging and Clinical Sciences (DNICS), Medicine and Ageing Sciences (DMSI), University Gabriele d'Annunzio, Chieti, Italy (S.B., F.P.).

Jean-Pierre Benitah (JP)

Signaling and Cardiovascular Pathophysiology - UMR-S 1180, Inserm, Université Paris-Saclay 92296 Châtenay-Malabry, France (L.Y., A.Z., R.R., P.J., E.M.-S., O.V., L.L., Y.Y.W., P.M., P.G., R.P., J.L.A., J.-P.B., A.M.G.).

Ana M Gómez (AM)

Signaling and Cardiovascular Pathophysiology - UMR-S 1180, Inserm, Université Paris-Saclay 92296 Châtenay-Malabry, France (L.Y., A.Z., R.R., P.J., E.M.-S., O.V., L.L., Y.Y.W., P.M., P.G., R.P., J.L.A., J.-P.B., A.M.G.).

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Classifications MeSH

questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système nerveux › Potentiels de membrane › Potentiels d'action › Impaired Binding to Junctophilin-2 and...
questionsmedicales.fr › Eucaryotes › Animaux › Impaired Binding to Junctophilin-2 and...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Sites de fixation › Impaired Binding to Junctophilin-2 and...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › Systèmes de seconds messagers › Signalisation calcique › Impaired Binding to Junctophilin-2 and...
questionsmedicales.fr › Cellules › Cellules cultivées › Impaired Binding to Junctophilin-2 and...
questionsmedicales.fr › Cellules › Cellules épithéliales › Cellules HEK293 › Impaired Binding to Junctophilin-2 and...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Impaired Binding to Junctophilin-2 and...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Impaired Binding to Junctophilin-2 and...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Impaired Binding to Junctophilin-2 and...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › Impaired Binding to Junctophilin-2 and...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Mutation › Impaired Binding to Junctophilin-2 and...
questionsmedicales.fr › Cellules › Cellules musculaires › Myocytes cardiaques › Impaired Binding to Junctophilin-2 and...
questionsmedicales.fr › Métabolisme › Liaison aux protéines › Impaired Binding to Junctophilin-2 and...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Canaux ioniques › Canaux calciques › Canal de libération du calcium du récepteur à la ryanodine › Impaired Binding to Junctophilin-2 and...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Troubles du rythme cardiaque › Tachycardie › Tachycardie ventriculaire › Impaired Binding to Junctophilin-2 and...