Epitope Mapping of Allergenic Lipid Transfer Proteins.
IgE-epitope mapping
Lipid transfer protein
Peptide microarray
Plant food allergy
Journal
Methods in molecular biology (Clifton, N.J.)
ISSN: 1940-6029
Titre abrégé: Methods Mol Biol
Pays: United States
ID NLM: 9214969
Informations de publication
Date de publication:
2021
2021
Historique:
entrez:
11
6
2021
pubmed:
12
6
2021
medline:
26
8
2021
Statut:
ppublish
Résumé
Food allergy is becoming a great problem in industrialized countries. Thus, there is the need for a robust understanding of all aspects characterizing IgE response to allergens. The epitope mapping of B-cell epitopes has the potential to become a fundamental tool for food allergy diagnosis and prognosis and to lead to a better understanding of the pathogenesis. Using this approach, we have worked on epitope mapping of the most important plant food allergens identified in the Mediterranean area. The final aim of this study is to define the immune response regarding B epitopes and its clinical relevance in LTP allergy. This chapter describes the protocol to produce microarrays using a library of overlapping peptides corresponding to the primary sequences of allergenic lipid transfer proteins.
Identifiants
pubmed: 34115355
doi: 10.1007/978-1-0716-1562-1_8
doi:
Substances chimiques
Carrier Proteins
0
lipid transfer protein
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
107-117Références
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