Comprehensive evaluation of two Astragalus species (A. campylosema and A. hirsutus) based on biological, toxicological properties and chemical profiling.
Antioxidant
Astragalus species
Cytotoxicity
Enzymes inhibition
Flavonoids
Genotoxicity
HeLa cell Line
Phenolics
Journal
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
ISSN: 1873-6351
Titre abrégé: Food Chem Toxicol
Pays: England
ID NLM: 8207483
Informations de publication
Date de publication:
Aug 2021
Aug 2021
Historique:
received:
08
05
2021
revised:
27
05
2021
accepted:
05
06
2021
pubmed:
12
6
2021
medline:
3
11
2021
entrez:
11
6
2021
Statut:
ppublish
Résumé
Astragalus L. (Fabaceae) is an important genus with numerous species having various traditional medicinal uses making them of interest for scientific investigations to ascertain their therapeutic benefits. In the present study, the quantitative polyphenolic profiles of methanolic extracts from different parts (leaves, flowers, and roots) of two endemic Astragalus species growing in Turkey, i.e. A. campylosema Boiss. and A. hirsutus Vahl were determined, along with their antioxidant and enzyme inhibitory properties. A. campylosema and A. hirsutus extracts showed varying total phenolic (25.80-40.60 and18.59-29.46 mg GAE/g, respectively) and total flavonoid (11.21-105.91 and 16.06-131.91 mg RE/g, respectively) contents. HPLC-MS/MS revealed rutin to be the predominant phenolic compound in all the extracts of A. campylosema and leaf extract of A. hirsutus (133.53-752.42 μg g
Identifiants
pubmed: 34116105
pii: S0278-6915(21)00363-X
doi: 10.1016/j.fct.2021.112330
pii:
doi:
Substances chimiques
Antioxidants
0
Enzyme Inhibitors
0
Flavonoids
0
Glycation End Products, Advanced
0
Plant Extracts
0
Polyphenols
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
112330Informations de copyright
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