Expression of DEP Domain-Containing 1B in Canine Lymphoma and Other Types of Canine Tumours.

Animals Dog Diseases Dogs GTPase-Activating Proteins / metabolism Immunohistochemistry / veterinary Lymph Nodes Lymphoma / veterinary
DEPDC1B cDNAmicroarray canine lymphoma

Journal

Journal of comparative pathology
ISSN: 1532-3129
Titre abrégé: J Comp Pathol
Pays: England
ID NLM: 0102444

Informations de publication

Date de publication:
May 2021
Historique:
received: 08 06 2020
revised: 08 01 2021
accepted: 19 04 2021
entrez: 13 6 2021
pubmed: 14 6 2021
medline: 9 11 2021
Statut: ppublish

Résumé

Canine lymphoma is the most common haematological malignancy in dogs and is typically treated with multidrug chemotherapy. Most cases are at risk of relapse after several courses of chemotherapy and the oncogenic mechanism remains unknown. This study was aimed at identifying genes expressed in canine lymphoma by cDNA microarray. We found elevated expression of Dishevelled, EGL-10 and pleckstrin (DEP) domain-containing 1B (DEPDC1B) in canine lymphoma cells compared with cells and tissues from healthy dogs. Canine DEPDC1B protein was detected in 13 of 41 lymphoma specimens by immunohistochemistry, but was not detected in lymph nodes from normal dogs. Immunoreactive DEPDC1B protein was also detected in several other types of canine tumour. This is the first report documenting the association of DEPDC1B with canine cancer and the results suggest that DEPDC1B might serve as a potential marker or therapeutic target for canine malignancies.

Identifiants

DOI: 10.1016/j.jcpa.2021.04.005 PMID: 34119232
pubmed: 34119232
pii: S0021-9975(21)00051-7
doi: 10.1016/j.jcpa.2021.04.005
pii:
doi:

Substances chimiques

GTPase-Activating Proteins 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

55-65

Informations de copyright

Copyright © 2021 Elsevier Ltd. All rights reserved.

Auteurs

Yuki Morinaga (Y)

Laboratory of Molecular Diagnostics and Therapeutics, Japan.

Masaya Igase (M)

Laboratory of Molecular Diagnostics and Therapeutics, Japan.

Takuma Yanase (T)

Laboratory of Molecular Diagnostics and Therapeutics, Japan.

Yusuke Sakai (Y)

Laboratory of Veterinary Pathology, Joint Faculty of Veterinary Medicine, Yamaguchi University, Yamaguchi, Japan.

Hiroki Sakai (H)

Laboratory of Veterinary Pathology, Faculty of Applied Biological Sciences, Gifu University, Gifu, Japan.

Aki Fujiwara-Igarashi (A)

Department of Veterinary Internal Medicine, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan.

Hajime Tsujimoto (H)

Department of Veterinary Internal Medicine, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan.

Masaru Okuda (M)

Laboratory of Veterinary Internal Medicine, Joint Faculty of Veterinary Medicine, Yamaguchi University, Yamaguchi, Japan.

Takuya Mizuno (T)

Laboratory of Molecular Diagnostics and Therapeutics, Japan. Electronic address: mizutaku@yamaguchi-u.ac.jp.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Expression of DEP Domain-Containing 1B in...
questionsmedicales.fr › Maladies de l'animal › Maladies des chiens › Expression of DEP Domain-Containing 1B in...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Carnivora › Pinnipedia › Canidae › Chiens › Expression of DEP Domain-Containing 1B in...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Régulateurs des protéines G › Protéines d'activation de la GTPase › Expression of DEP Domain-Containing 1B in...
questionsmedicales.fr › Disciplines des sciences naturelles › Chimie › Biochimie › Immunohistochimie › Expression of DEP Domain-Containing 1B in...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Système lymphatique › Tissu lymphoïde › Noeuds lymphatiques › Expression of DEP Domain-Containing 1B in...
questionsmedicales.fr › Maladies du système immunitaire › Syndromes immunoprolifératifs › Syndromes lymphoprolifératifs › Lymphomes › Expression of DEP Domain-Containing 1B in...