Immunogenicity of BNT162b2 mRNA COVID-19 vaccine and SARS-CoV-2 infection in lung transplant recipients.
COVID-19
antibody response
immunogenicity
lung transplantation
mRNA vaccine
Journal
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation
ISSN: 1557-3117
Titre abrégé: J Heart Lung Transplant
Pays: United States
ID NLM: 9102703
Informations de publication
Date de publication:
08 2021
08 2021
Historique:
received:
03
04
2021
revised:
10
05
2021
accepted:
11
05
2021
pubmed:
15
6
2021
medline:
8
9
2021
entrez:
14
6
2021
Statut:
ppublish
Résumé
The immunogenicity of the novel mRNA COVID-19 vaccine in immunocompromised lung transplant recipients is still unknown. We compared the antibody response after the first and second doses of the BNT162b2 mRNA COVID-19 vaccine (Pfizer-BioNTech) with the response after natural SARS-CoV-2 infection in lung transplant recipients. None of the vaccinees tested after two doses of the mRNA BNT162b2 vaccine developed anti-SARS-CoV-2 IgG, while 85% patients presented an antibody response after SARS-CoV-2 infection. The absence of antibody response to vaccination led us to investigate the cellular response in a subset of patients. We detected SARS-CoV-2 specific T-cells in 4 out of 12 tested patients. Some patients therefore might have clinical benefit from the vaccine despite an absent antibody response. These results contrast with the excellent antibody response in immunocompetent individuals observed in mRNA BNT162b2 trials and indicate an urgent need to identify the best vaccine type and scheme for immunocompromised transplanted patients.
Identifiants
pubmed: 34120839
pii: S1053-2498(21)02318-4
doi: 10.1016/j.healun.2021.05.004
pmc: PMC8139179
pii:
doi:
Substances chimiques
COVID-19 Vaccines
0
BNT162 Vaccine
N38TVC63NU
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
754-758Commentaires et corrections
Type : CommentIn
Informations de copyright
Copyright © 2021 International Society for Heart and Lung Transplantation. Published by Elsevier Inc. All rights reserved.
Références
Cytometry B Clin Cytom. 2017 Sep;92(5):380-388
pubmed: 26647177
Am J Transplant. 2021 May;21(5):1816-1824
pubmed: 33089648
JAMA. 2021 May 4;325(17):1784-1786
pubmed: 33720292
Transplantation. 2021 Jan 1;105(1):177-186
pubmed: 33141808
Am J Transplant. 2020 Nov;20(11):3072-3080
pubmed: 32881315
Transpl Infect Dis. 2020 Dec;22(6):e13364
pubmed: 32521074