Functional Insights into the High-Molecular-Mass Penicillin-Binding Proteins of Streptococcus agalactiae Revealed by Gene Deletion and Transposon Mutagenesis Analysis.

Anti-Bacterial Agents / pharmacology Bacterial Proteins / chemistry Gene Deletion Mutagenesis Mutagenesis, Insertional Penicillin-Binding Proteins / chemistry Penicillins / pharmacology Streptococcus agalactiae / drug effects
TraDIS group B streptococcus penicillin-binding proteins

Journal

Journal of bacteriology
ISSN: 1098-5530
Titre abrégé: J Bacteriol
Pays: United States
ID NLM: 2985120R

Informations de publication

Date de publication:
09 08 2021
Historique:
pubmed: 15 6 2021
medline: 21 10 2021
entrez: 14 6 2021
Statut: ppublish

Résumé

High-molecular-mass penicillin-binding proteins (PBPs) are enzymes that catalyze the biosynthesis of bacterial cell wall peptidoglycan. The Gram-positive bacterial pathogen Streptococcus agalactiae (group B streptococcus [GBS]) produces five high-molecular-mass PBPs, namely, PBP1A, PBP1B, PBP2A, PBP2B, and PBP2X. Among these, only PBP2X is essential for cell viability, whereas the other four PBPs are individually dispensable. The biological function of the four nonessential PBPs is poorly characterized in GBS. We deleted the

Identifiants

DOI: 10.1128/JB.00234-21 PMID: 34124943 PMC: PMC8351624
pubmed: 34124943
doi: 10.1128/JB.00234-21
pmc: PMC8351624
doi:

Substances chimiques

Anti-Bacterial Agents 0
Bacterial Proteins 0
Penicillin-Binding Proteins 0
Penicillins 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

e0023421

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Auteurs

Luchang Zhu (L)

Center for Molecular and Translational Human Infectious Diseases Research, Houston Methodist Research Institute, Department of Pathology and Genomic Medicine, Houston Methodist Hospital, Houston, Texas, USA.
Department of Pathology and Laboratory Medicine, Weill Medical College of Cornell University, New York, New York, USA.

Prasanti Yerramilli (P)

Center for Molecular and Translational Human Infectious Diseases Research, Houston Methodist Research Institute, Department of Pathology and Genomic Medicine, Houston Methodist Hospital, Houston, Texas, USA.

Layne Pruitt (L)

Center for Molecular and Translational Human Infectious Diseases Research, Houston Methodist Research Institute, Department of Pathology and Genomic Medicine, Houston Methodist Hospital, Houston, Texas, USA.

Abhishek Mishra (A)

Center for Molecular and Translational Human Infectious Diseases Research, Houston Methodist Research Institute, Department of Pathology and Genomic Medicine, Houston Methodist Hospital, Houston, Texas, USA.

Randall J Olsen (RJ)

Center for Molecular and Translational Human Infectious Diseases Research, Houston Methodist Research Institute, Department of Pathology and Genomic Medicine, Houston Methodist Hospital, Houston, Texas, USA.
Department of Pathology and Laboratory Medicine, Weill Medical College of Cornell University, New York, New York, USA.

Stephen B Beres (SB)

Center for Molecular and Translational Human Infectious Diseases Research, Houston Methodist Research Institute, Department of Pathology and Genomic Medicine, Houston Methodist Hospital, Houston, Texas, USA.

Andrew S Waller (AS)

Intervacc, Stockholm, Sweden.
Department of Biomedical Science and Veterinary Public Health, Swedish University of Agricultural Sciences, Uppsala, Sweden.

James M Musser (JM)

Center for Molecular and Translational Human Infectious Diseases Research, Houston Methodist Research Institute, Department of Pathology and Genomic Medicine, Houston Methodist Hospital, Houston, Texas, USA.
Department of Pathology and Laboratory Medicine, Weill Medical College of Cornell University, New York, New York, USA.

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Classifications MeSH

questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antibactériens › Functional Insights into the...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines bactériennes › Functional Insights into the...
questionsmedicales.fr › Phénomènes génétiques › Mutagenèse › Délétion de séquence › Délétion de gène › Functional Insights into the...
questionsmedicales.fr › Phénomènes génétiques › Mutagenèse › Functional Insights into the...
questionsmedicales.fr › Phénomènes génétiques › Mutagenèse › Mutagenèse par insertion › Functional Insights into the...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines bactériennes › Protéines de liaison aux pénicillines › Functional Insights into the...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › bêta-Lactames › Pénicillines › Functional Insights into the...
questionsmedicales.fr › Bactéries › Bactéries à Gram positif › Lactobacillales › Streptococcaceae › Streptococcus › Streptococcus agalactiae › Functional Insights into the...