Antioxidant activity of Lactobacillus plantarum NJAU-01 in an animal model of aging.
Antioxidant capacity
D-galactose-induced aging animal
Jinhua Ham
Lactobacillus plantarum NJAU-01
Malondialdehyde
Journal
BMC microbiology
ISSN: 1471-2180
Titre abrégé: BMC Microbiol
Pays: England
ID NLM: 100966981
Informations de publication
Date de publication:
15 06 2021
15 06 2021
Historique:
received:
04
01
2021
accepted:
03
06
2021
entrez:
16
6
2021
pubmed:
17
6
2021
medline:
15
12
2021
Statut:
epublish
Résumé
Excessive reactive oxygen species (ROS) can cause serious damage to the human body and may cause various chronic diseases. Studies have found that lactic acid bacteria (LAB) have antioxidant and anti-aging effects, and are important resources for the development of microbial antioxidants. This paper was to explore the potential role of an antioxidant strain, Lactobacillus plantarum NJAU-01 screened from traditional dry-cured meat product Jinhua Ham in regulating D-galactose-induced subacute senescence of mice. A total of 48 specific pathogen free Kun Ming mice (SPF KM mice) were randomly allocated into 6 groups: control group with sterile saline injection, aging group with subcutaneously injection of D-galactose, treatments groups with injection of D-galactose and intragastric administration of 10 The results showed that the treatment group of L. plantarum NJAU-01 at 10 Thus, this study demonstrates that L. plantarum NJAU-01 can alleviate oxidative stress by increasing the activities of enzymes involved in oxidation resistance and decreasing level of lipid oxidation in mice.
Sections du résumé
BACKGROUND
Excessive reactive oxygen species (ROS) can cause serious damage to the human body and may cause various chronic diseases. Studies have found that lactic acid bacteria (LAB) have antioxidant and anti-aging effects, and are important resources for the development of microbial antioxidants. This paper was to explore the potential role of an antioxidant strain, Lactobacillus plantarum NJAU-01 screened from traditional dry-cured meat product Jinhua Ham in regulating D-galactose-induced subacute senescence of mice. A total of 48 specific pathogen free Kun Ming mice (SPF KM mice) were randomly allocated into 6 groups: control group with sterile saline injection, aging group with subcutaneously injection of D-galactose, treatments groups with injection of D-galactose and intragastric administration of 10
RESULTS
The results showed that the treatment group of L. plantarum NJAU-01 at 10
CONCLUSIONS
Thus, this study demonstrates that L. plantarum NJAU-01 can alleviate oxidative stress by increasing the activities of enzymes involved in oxidation resistance and decreasing level of lipid oxidation in mice.
Identifiants
pubmed: 34130624
doi: 10.1186/s12866-021-02248-5
pii: 10.1186/s12866-021-02248-5
pmc: PMC8207596
doi:
Substances chimiques
Antioxidants
0
Malondialdehyde
4Y8F71G49Q
Catalase
EC 1.11.1.6
Glutathione Peroxidase
EC 1.11.1.9
Superoxide Dismutase
EC 1.15.1.1
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
182Subventions
Organisme : Jiangsu Agriculture Science and Technology Innovation Fund
ID : CX(18)1006,CX(19)2018)
Organisme : Natural Science Foundation of Jiangsu Province
ID : BK20190888
Organisme : National Natural Science Foundation of China
ID : No. 31901610
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