Viral load and disease severity in COVID-19.
COVID-19
Coronavirus
Organ dysfunction score
RT-PCR
SARS-CoV-2
Viral load
Journal
Internal and emergency medicine
ISSN: 1970-9366
Titre abrégé: Intern Emerg Med
Pays: Italy
ID NLM: 101263418
Informations de publication
Date de publication:
03 2022
03 2022
Historique:
received:
28
03
2021
accepted:
03
06
2021
pubmed:
17
6
2021
medline:
5
4
2022
entrez:
16
6
2021
Statut:
ppublish
Résumé
The relationship between COVID-19 severity and viral load is unknown. Our objective was to assess the association between viral load and disease severity in COVID-19. In this single center observational study of adults with laboratory confirmed SARS-CoV-2, the first positive in-hospital nasopharyngeal swab was used to calculate the log10 copies/ml [log10 copy number (CN)] of SARS-CoV-2. Four categories based on level of care and modified sequential organ failure assessment score (mSOFA) at time of swab were determined. Median log10CN was compared between different levels of care and mSOFA quartiles. Median log10CN was compared in patients who did and did not receive influenza vaccine, and the correlation between log10CN and D-dimer was examined. We found that of 396 patients, 54.3% were male, and 25% had no major comorbidity. Hospital mortality was 15.7%. Median mSOFA was 2 (IQR 0-3). Median log10CN was 5.5 (IQR 3.3-8.0). Median log10CN was highest in non-intubated ICU patients [6.4 (IQR 4.4-8.1)] and lowest in intubated ICU patients [3.6 (IQR 2.6-6.9)] (p value < 0.01). In adjusted analyses, this difference remained significant [mean difference 1.16 (95% CI 0.18-2.14)]. There was no significant difference in log10CN between other groups in the remaining pairwise comparisons. There was no association between median log10CN and mSOFA in either unadjusted or adjusted analyses or between median log10CN in patients with and without influenza immunization. There was no correlation between log10CN and D-dimer. We conclude, in our cohort, we did not find a clear association between viral load and disease severity in COVID-19 patients. Though viral load was higher in non-intubated ICU patients than in intubated ICU patients there were no other significant differences in viral load by disease severity.
Identifiants
pubmed: 34133005
doi: 10.1007/s11739-021-02786-w
pii: 10.1007/s11739-021-02786-w
pmc: PMC8206885
doi:
Types de publication
Journal Article
Observational Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
359-367Subventions
Organisme : NHLBI NIH HHS
ID : R01 HL136705
Pays : United States
Organisme : NHLBI NIH HHS
ID : K24 HL127101
Pays : United States
Organisme : NIH HHS
ID : 1R03 AA026093
Pays : United States
Organisme : NIH HHS
ID : K24HL127101
Pays : United States
Organisme : NIH HHS
ID : R01HL136705
Pays : United States
Organisme : NIH HHS
ID : 1R01DK112886
Pays : United States
Organisme : NHLBI NIH HHS
ID : K23 HL128814
Pays : United States
Informations de copyright
© 2021. Società Italiana di Medicina Interna (SIMI).
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