The long lives of primates and the 'invariant rate of ageing' hypothesis.
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
16 06 2021
16 06 2021
Historique:
received:
29
11
2020
accepted:
19
05
2021
entrez:
17
6
2021
pubmed:
18
6
2021
medline:
29
6
2021
Statut:
epublish
Résumé
Is it possible to slow the rate of ageing, or do biological constraints limit its plasticity? We test the 'invariant rate of ageing' hypothesis, which posits that the rate of ageing is relatively fixed within species, with a collection of 39 human and nonhuman primate datasets across seven genera. We first recapitulate, in nonhuman primates, the highly regular relationship between life expectancy and lifespan equality seen in humans. We next demonstrate that variation in the rate of ageing within genera is orders of magnitude smaller than variation in pre-adult and age-independent mortality. Finally, we demonstrate that changes in the rate of ageing, but not other mortality parameters, produce striking, species-atypical changes in mortality patterns. Our results support the invariant rate of ageing hypothesis, implying biological constraints on how much the human rate of ageing can be slowed.
Identifiants
pubmed: 34135334
doi: 10.1038/s41467-021-23894-3
pii: 10.1038/s41467-021-23894-3
pmc: PMC8209124
doi:
Banques de données
Dryad
['10.5061/dryad.4b8gthtb4']
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
3666Subventions
Organisme : NIA NIH HHS
ID : P01 AG031719
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG053330
Pays : United States
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