Elovl5 is required for proper action potential conduction along peripheral myelinated fibers.
Elovl5
action potential
axon
myelin
polyunsaturated fatty acids
Journal
Glia
ISSN: 1098-1136
Titre abrégé: Glia
Pays: United States
ID NLM: 8806785
Informations de publication
Date de publication:
10 2021
10 2021
Historique:
revised:
31
05
2021
received:
09
10
2020
accepted:
03
06
2021
pubmed:
18
6
2021
medline:
12
3
2022
entrez:
17
6
2021
Statut:
ppublish
Résumé
Elovl5 elongates fatty acids with 18 carbon atoms and in cooperation with other enzymes guarantees the normal levels of very long-chain fatty acids, which are necessary for a proper membrane structure. Action potential conduction along myelinated axons depends on structural integrity of myelin, which is maintained by a correct amount of fatty acids and a proper interaction between fatty acids and myelin proteins. We hypothesized that in Elovl5
Identifiants
pubmed: 34139039
doi: 10.1002/glia.24048
pmc: PMC8453547
doi:
Substances chimiques
Fatty Acids
0
Elovl5 protein, mouse
EC 2.3.1.-
Fatty Acid Elongases
EC 2.3.1.-
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2419-2428Informations de copyright
© 2021 The Authors. GLIA published by Wiley Periodicals LLC.
Références
Cell Metab. 2015 Apr 7;21(4):571-83
pubmed: 25817536
J Neurosci. 2007 Aug 29;27(35):9482-90
pubmed: 17728461
Nat Rev Mol Cell Biol. 2018 May;19(5):281-296
pubmed: 29410529
PLoS One. 2012;7(12):e52904
pubmed: 23300814
Brain Pathol. 2001 Jan;11(1):74-91
pubmed: 11145205
Acta Neuropathol. 1995;90(2):158-63
pubmed: 7484091
J Histochem Cytochem. 2019 Mar;67(3):203-219
pubmed: 30501365
Biochim Biophys Acta. 2006 Dec;1758(12):1864-84
pubmed: 17052686
Nat Rev Mol Cell Biol. 2017 Jun;18(6):361-374
pubmed: 28356571
J Neural Transm Suppl. 1999;55:9-17
pubmed: 10335489
PLoS Comput Biol. 2019 Oct 17;15(10):e1007004
pubmed: 31622338
J Neurosci. 2002 Aug 1;22(15):6507-14
pubmed: 12151530
Biophys J. 2004 Nov;87(5):2976-89
pubmed: 15315947
Front Cell Neurosci. 2017 Oct 30;11:343
pubmed: 29163054
J Clin Invest. 2014 Jun;124(6):2560-70
pubmed: 24762439
Glia. 2006 Mar;53(4):372-81
pubmed: 16288467
J Lipid Res. 1965 Oct;6(4):537-44
pubmed: 5865382
J Lipid Res. 2009 Mar;50(3):412-423
pubmed: 18838740
Nat Rev Mol Cell Biol. 2008 Feb;9(2):112-24
pubmed: 18216768
J Neurochem. 1973 Oct;21(4):759-73
pubmed: 4754856
Neurobiol Dis. 2019 Apr;124:14-28
pubmed: 30389403
Biochim Biophys Acta. 2016 Oct;1858(10):2569-2572
pubmed: 26827711
Int J Mol Sci. 2019 Jul 21;20(14):
pubmed: 31330872
J Lipid Res. 2018 Jun;59(6):1015-1026
pubmed: 29500230
Trends Cell Biol. 2000 Oct;10(10):408-12
pubmed: 10998592
Elife. 2017 Jan 28;6:
pubmed: 28130923
Proc Natl Acad Sci U S A. 2009 Mar 3;106(9):3154-9
pubmed: 19218452
Ann Anat. 2000 Jan;182(1):23-34
pubmed: 10668555
J Physiol. 2011 Feb 1;589(Pt 3):559-73
pubmed: 21098009
Results Probl Cell Differ. 2009;48:1-28
pubmed: 19343313
Neurobiol Aging. 2018 Aug;68:123-133
pubmed: 29602494
J Clin Invest. 2019 Mar 1;129(3):1229-1239
pubmed: 30620338
Brain. 2019 Nov 1;142(11):3382-3397
pubmed: 31637422
J Neurosci Res. 2016 Nov;94(11):1042-8
pubmed: 27638590
Cold Spring Harb Perspect Biol. 2014 Oct 30;7(2):a016311
pubmed: 25359497
Sci Rep. 2019 May 29;9(1):8000
pubmed: 31142762
Exp Neurol. 2015 May;267:209-18
pubmed: 25792482
J Neuropathol Exp Neurol. 2013 Mar;72(3):256-62
pubmed: 23399903
Prog Lipid Res. 2010 Apr;49(2):186-99
pubmed: 20018209
Free Radic Biol Med. 2015 Jul;84:296-310
pubmed: 25801291
J Med Genet. 2018 Jun;55(6):408-414
pubmed: 29496980
Neurogenetics. 2018 Dec;19(4):227-235
pubmed: 30043326
Biochim Biophys Acta. 2004 Jan 20;1688(1):10-7
pubmed: 14732476
Glia. 2021 Oct;69(10):2419-2428
pubmed: 34139039
Glia. 2019 Nov;67(11):2050-2062
pubmed: 31233642