Investigation of the association between cerebral iron content and myelin content in normative aging using quantitative magnetic resonance neuroimaging.
Adult
Aged
Aged, 80 and over
Aging
/ metabolism
Body Water
Brain Chemistry
Cross-Sectional Studies
Female
Gray Matter
/ diagnostic imaging
Humans
Image Processing, Computer-Assisted
Iron
/ analysis
Magnetic Resonance Imaging
/ methods
Male
Middle Aged
Myelin Sheath
/ chemistry
Oligodendroglia
/ chemistry
White Matter
/ diagnostic imaging
Young Adult
Aging
Iron
Myelin
Quantitative MRI
Journal
NeuroImage
ISSN: 1095-9572
Titre abrégé: Neuroimage
Pays: United States
ID NLM: 9215515
Informations de publication
Date de publication:
01 10 2021
01 10 2021
Historique:
received:
31
01
2021
revised:
10
06
2021
accepted:
11
06
2021
pubmed:
18
6
2021
medline:
29
10
2021
entrez:
17
6
2021
Statut:
ppublish
Résumé
Myelin loss and iron accumulation are cardinal features of aging and various neurodegenerative diseases. Oligodendrocytes incorporate iron as a metabolic substrate for myelin synthesis and maintenance. An emerging hypothesis in Alzheimer's disease research suggests that myelin breakdown releases substantial stores of iron that may accumulate, leading to further myelin breakdown and neurodegeneration. We assessed associations between iron content and myelin content in critical brain regions using quantitative magnetic resonance imaging (MRI) on a cohort of cognitively unimpaired adults ranging in age from 21 to 94 years. We measured whole-brain myelin water fraction (MWF), a surrogate of myelin content, using multicomponent relaxometry, and whole-brain iron content using susceptibility weighted imaging in all individuals. MWF was negatively associated with iron content in most brain regions evaluated indicating that lower myelin content corresponds to higher iron content. Moreover, iron content was significantly higher with advanced age in most structures, with men exhibiting a trend towards higher iron content as compared to women. Finally, relationship between MWF and age, in all brain regions investigated, suggests that brain myelination continues until middle age, followed by degeneration at older ages. This work establishes a foundation for further investigations of the etiology and sequelae of myelin breakdown and iron accumulation in neurodegeneration and may lead to new imaging markers for disease progression and treatment.
Identifiants
pubmed: 34139358
pii: S1053-8119(21)00543-7
doi: 10.1016/j.neuroimage.2021.118267
pmc: PMC8370037
mid: NIHMS1732172
pii:
doi:
Substances chimiques
Iron
E1UOL152H7
Types de publication
Comparative Study
Journal Article
Research Support, N.I.H., Intramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
118267Subventions
Organisme : NIA NIH HHS
ID : P30 AG066507
Pays : United States
Organisme : Intramural NIH HHS
ID : Z99 AG999999
Pays : United States
Informations de copyright
Copyright © 2021. Published by Elsevier Inc.
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