Reference Intervals for Serum Thyroid-Stimulating Hormone Based on a Recent Nationwide Cross-Sectional Study and Meta-Analysis.


Journal

Frontiers in endocrinology
ISSN: 1664-2392
Titre abrégé: Front Endocrinol (Lausanne)
Pays: Switzerland
ID NLM: 101555782

Informations de publication

Date de publication:
2021
Historique:
received: 29 01 2021
accepted: 29 03 2021
entrez: 18 6 2021
pubmed: 19 6 2021
medline: 13 1 2022
Statut: epublish

Résumé

The aim of our study was to compare the reference intervals (RIs) [median (2.5 Primary data were derived from a recently published cross-sectional study in mainland China. Secondary data were obtained from online databases. The RIs for TSH were calculated in the reference population according to the National Academy of Clinical Biochemistry (NACB) standard and in the disease-free population. A meta-analysis of ethnicity- and iodine status-specific TSH RIs was performed. The primary data showed that the TSH RI (mU/L) in the disease-free population was 2.33 (0.67, 7.87), which is wider than the published RI [2.28 (0.74, 7.04)] in the reference population. The meta-analysis showed that whether in the reference or disease-free population, the RIs in Yellows were much higher than those in Caucasians. In the reference population, the median and 2.5 Yellows have a higher TSH RI than Caucasians. In the reference population, both the median and 2.5

Identifiants

pubmed: 34140930
doi: 10.3389/fendo.2021.660277
pmc: PMC8204855
doi:

Substances chimiques

Thyrotropin 9002-71-5
Iodine 9679TC07X4

Types de publication

Journal Article Meta-Analysis Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

660277

Informations de copyright

Copyright © 2021 Wang, Li, Zhai, Wang, Zhang, Gao, Liu, Teng and Shan.

Déclaration de conflit d'intérêts

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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Auteurs

Xichang Wang (X)

Department of Endocrinology and Metabolism and the institute of Endocrinology, The NHC Key Laboratory of Diagnosis and Treatment of Thyroid Diseases, The First Hospital of China Medical University, Shenyang, China.

Yongze Li (Y)

Department of Endocrinology and Metabolism and the institute of Endocrinology, The NHC Key Laboratory of Diagnosis and Treatment of Thyroid Diseases, The First Hospital of China Medical University, Shenyang, China.

Xiaodan Zhai (X)

Department of Endocrinology and Metabolism, Shengjing Affiliated Hospital of China Medical University, Shenyang, China.

Haoyu Wang (H)

Department of Endocrinology and Metabolism and the institute of Endocrinology, The NHC Key Laboratory of Diagnosis and Treatment of Thyroid Diseases, The First Hospital of China Medical University, Shenyang, China.

Fan Zhang (F)

Department of Endocrinology and Metabolism and the institute of Endocrinology, The NHC Key Laboratory of Diagnosis and Treatment of Thyroid Diseases, The First Hospital of China Medical University, Shenyang, China.

Xiaotong Gao (X)

Department of Endocrinology and Metabolism and the institute of Endocrinology, The NHC Key Laboratory of Diagnosis and Treatment of Thyroid Diseases, The First Hospital of China Medical University, Shenyang, China.

Shengyu Liu (S)

Department of Endocrinology and Metabolism and the institute of Endocrinology, The NHC Key Laboratory of Diagnosis and Treatment of Thyroid Diseases, The First Hospital of China Medical University, Shenyang, China.

Weiping Teng (W)

Department of Endocrinology and Metabolism and the institute of Endocrinology, The NHC Key Laboratory of Diagnosis and Treatment of Thyroid Diseases, The First Hospital of China Medical University, Shenyang, China.

Zhongyan Shan (Z)

Department of Endocrinology and Metabolism and the institute of Endocrinology, The NHC Key Laboratory of Diagnosis and Treatment of Thyroid Diseases, The First Hospital of China Medical University, Shenyang, China.

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