A review of significance of Aspergillus detection in airways of ICU COVID-19 patients.
Aspergillus fumigatus
COVID-19
SARS-CoV-2
colonisation
intensive care unit
invasive pulmonary aspergillosis
mortality
Journal
Mycoses
ISSN: 1439-0507
Titre abrégé: Mycoses
Pays: Germany
ID NLM: 8805008
Informations de publication
Date de publication:
Sep 2021
Sep 2021
Historique:
revised:
31
05
2021
received:
22
02
2021
accepted:
05
06
2021
pubmed:
19
6
2021
medline:
20
8
2021
entrez:
18
6
2021
Statut:
ppublish
Résumé
It is now well known that patients with SARS-CoV-2 infection admitted in ICU and mechanically ventilated are at risk of developing invasive pulmonary aspergillosis (IPA). Nevertheless, symptomatology of IPA is often atypical in mechanically ventilated patients, and radiological aspects in SARS-CoV-2 pneumonia and IPA are difficult to differentiate. In this context, the significance of the presence of Aspergillus in airway specimens (detected by culture, galactomannan antigen or specific PCR) remains to be fully understood. To decipher the relevance of the detection of Aspergillus, we performed a comprehensive review of all published cases of respiratory Aspergillus colonisation and IPA in COVID-19 patients. The comparison of patients receiving or not antifungal treatment allowed us to highlight the most important criteria for the decision to treat. The comparison of surviving and non-surviving patients made it possible to unveil criteria associated with mortality that should be taken into account in the treatment decision.
Identifiants
pubmed: 34143533
doi: 10.1111/myc.13341
pmc: PMC8447125
doi:
Substances chimiques
Antifungal Agents
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
980-988Informations de copyright
© 2021 Wiley-VCH GmbH.
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