Cell-specific and divergent roles of the CD40L-CD40 axis in atherosclerotic vascular disease.


Journal

Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555

Informations de publication

Date de publication:
18 06 2021
Historique:
received: 02 02 2020
accepted: 19 05 2021
entrez: 19 6 2021
pubmed: 20 6 2021
medline: 7 7 2021
Statut: epublish

Résumé

Atherosclerosis is a major underlying cause of cardiovascular disease. Previous studies showed that inhibition of the co-stimulatory CD40 ligand (CD40L)-CD40 signaling axis profoundly attenuates atherosclerosis. As CD40L exerts multiple functions depending on the cell-cell interactions involved, we sought to investigate the function of the most relevant CD40L-expressing cell types in atherosclerosis: T cells and platelets. Atherosclerosis-prone mice with a CD40L-deficiency in CD4

Identifiants

pubmed: 34145241
doi: 10.1038/s41467-021-23909-z
pii: 10.1038/s41467-021-23909-z
pmc: PMC8213756
doi:

Substances chimiques

CD40 Antigens 0
IFNG protein, mouse 0
CD40 Ligand 147205-72-9
Interferon-gamma 82115-62-6

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

3754

Commentaires et corrections

Type : CommentIn

Références

J Biol Chem. 2005 Nov 11;280(45):37610-5
pubmed: 16157583
J Clin Invest. 2004 Aug;114(3):427-37
pubmed: 15286809
Mol Cancer Ther. 2021 Feb;20(2):357-366
pubmed: 33298591
Cell. 1994 Jun 17;77(6):917-29
pubmed: 8004678
Nat Rev Dis Primers. 2019 Aug 16;5(1):56
pubmed: 31420554
Proc Natl Acad Sci U S A. 2000 Jun 20;97(13):7458-63
pubmed: 10861012
Eur J Vasc Endovasc Surg. 1996 Oct;12(3):331-6
pubmed: 8896476
Arterioscler Thromb Vasc Biol. 2017 May;37(5):764-777
pubmed: 28360089
Oncotarget. 2017 May 30;8(22):35542-35557
pubmed: 28415767
Arterioscler Thromb Vasc Biol. 2018 Aug;38(8):1678-1688
pubmed: 29930003
Blood. 2018 Sep 27;132(13):1413-1425
pubmed: 29891536
Proc Natl Acad Sci U S A. 2000 Jun 20;97(13):7464-9
pubmed: 10861013
Circulation. 2002 Jul 23;106(4):399-402
pubmed: 12135935
Blood. 2007 Feb 15;109(4):1503-6
pubmed: 17032923
Immunol Cell Biol. 1998 Feb;76(1):34-40
pubmed: 9553774
Nat Med. 2002 Mar;8(3):247-52
pubmed: 11875495
Circ Res. 2016 Nov 11;119(11):1190-1203
pubmed: 27635087
Circulation. 2011 Jul 12;124(2):185-95
pubmed: 21690490
J Clin Invest. 1997 Jun 1;99(11):2752-61
pubmed: 9169506
Annu Rev Immunol. 2004;22:307-28
pubmed: 15032580
N Engl J Med. 2019 Dec 26;381(26):2497-2505
pubmed: 31733140
Circulation. 2019 May 21;139(21):2466-2482
pubmed: 30894016
J Am Coll Cardiol. 2018 Feb 6;71(5):527-542
pubmed: 29406859
Nat Commun. 2018 Feb 6;9(1):525
pubmed: 29410422
J Immunol. 2010 Aug 1;185(3):1577-83
pubmed: 20585032
Genome Biol. 2014;15(12):550
pubmed: 25516281
Stroke. 2003 Mar;34(3):616-22
pubmed: 12624281
Circulation. 2003 Dec 2;108(22):2776-82
pubmed: 14623801
Nat Med. 2006 Feb;12(2):178-80
pubmed: 16462800
Atherosclerosis. 2019 Dec;291:127-131
pubmed: 31558283
Sci Rep. 2019 Oct 11;9(1):14702
pubmed: 31604965
Arterioscler Thromb Vasc Biol. 2015 Jun;35(6):1374-81
pubmed: 25908768
Arterioscler Thromb Vasc Biol. 2015 Jan;35(1):222-8
pubmed: 25359857
N Engl J Med. 2007 Dec 13;357(24):2482-94
pubmed: 18077812
Circulation. 2003 Apr 29;107(16):2140-5
pubmed: 12695304
Arterioscler Thromb Vasc Biol. 2000 May;20(5):1262-75
pubmed: 10807742
BMJ Open Diabetes Res Care. 2019 Dec 17;7(1):e000829
pubmed: 31908798
N Engl J Med. 2003 Mar 20;348(12):1104-11
pubmed: 12646667
N Engl J Med. 2020 Nov 5;383(19):1838-1847
pubmed: 32865380
Nat Rev Cardiol. 2019 Jan;16(1):21-32
pubmed: 30209355
J Exp Med. 2007 Jul 9;204(7):1653-64
pubmed: 17591855
F1000Res. 2017 Nov 14;6:2010
pubmed: 29333246
Thromb Haemost. 2016 Sep 27;116(4):605-12
pubmed: 27384503
Arterioscler Thromb Vasc Biol. 2005 Jun;25(6):1244-9
pubmed: 15746436
Blood. 2010 Nov 18;116(20):4317-27
pubmed: 20705757
Mol Cell. 2010 May 28;38(4):576-89
pubmed: 20513432
Nat Biomed Eng. 2018 May;2(5):279-292
pubmed: 30936448
BMJ Open. 2018 Sep 17;8(9):e022452
pubmed: 30224390
N Engl J Med. 2017 Sep 21;377(12):1119-1131
pubmed: 28845751
Science. 1993 Sep 3;261(5126):1328-30
pubmed: 7689748
Atherosclerosis. 2005 Dec;183(2):275-82
pubmed: 16002076
J Exp Med. 2010 Feb 15;207(2):391-404
pubmed: 20100871
Arthritis Rheum. 2003 Mar;48(3):719-27
pubmed: 12632425
BMC Cardiovasc Disord. 2014 Aug 30;14:111
pubmed: 25175336
Circulation. 2004 Oct 26;110(17):2552-8
pubmed: 15505108
Arterioscler Thromb Vasc Biol. 2010 Dec;30(12):2424-33
pubmed: 21071692
Trends Cardiovasc Med. 2007 May;17(4):118-23
pubmed: 17482093
Nat Med. 1999 Nov;5(11):1313-6
pubmed: 10546000
Bioinformatics. 2009 Aug 15;25(16):2078-9
pubmed: 19505943
Arterioscler Thromb Vasc Biol. 2020 Apr;40(4):853-864
pubmed: 32078364
Proc Natl Acad Sci U S A. 1997 Mar 4;94(5):1931-6
pubmed: 9050882
Proc Natl Acad Sci U S A. 2008 Jan 22;105(3):973-8
pubmed: 18198277
Immunity. 1994 Jun;1(3):167-78
pubmed: 7534202
Cell Mol Life Sci. 2016 Mar;73(5):901-22
pubmed: 26518635
Nat Rev Cardiol. 2019 Mar;16(3):180-196
pubmed: 30410107
Front Cardiovasc Med. 2017 Jun 20;4:40
pubmed: 28676852
Circ Res. 2019 Jan 18;124(2):315-327
pubmed: 30653442
Immunity. 2015 Jun 16;42(6):1048-61
pubmed: 26070482
Arterioscler Thromb. 1991 Sep-Oct;11(5):1223-30
pubmed: 1911708
Nature. 1998 Jul 9;394(6689):200-3
pubmed: 9671306
Immunity. 2013 Jun 27;38(6):1092-104
pubmed: 23809160
Haematologica. 2019 Jun;104(6):1256-1267
pubmed: 30545925

Auteurs

Michael Lacy (M)

Institute for Cardiovascular Prevention (IPEK), Ludwig-Maximilians-Universität, Munich, Germany.
German Centre for Cardiovascular Research (DZHK), partner site Munich Heart Alliance, Munich, Germany.

Christina Bürger (C)

Institute for Cardiovascular Prevention (IPEK), Ludwig-Maximilians-Universität, Munich, Germany.

Annelie Shami (A)

Department of Clinical Sciences Malmö, Lund University, Clinical Research Center, Malmö, Sweden.

Maiwand Ahmadsei (M)

Institute for Cardiovascular Prevention (IPEK), Ludwig-Maximilians-Universität, Munich, Germany.
German Centre for Cardiovascular Research (DZHK), partner site Munich Heart Alliance, Munich, Germany.
Klinik und Poliklinik für Innere Medizin I, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.

Holger Winkels (H)

Institute for Cardiovascular Prevention (IPEK), Ludwig-Maximilians-Universität, Munich, Germany.
Department III for Internal Medicine, University Hospital Cologne, Cologne, Germany.

Katrin Nitz (K)

Institute for Cardiovascular Prevention (IPEK), Ludwig-Maximilians-Universität, Munich, Germany.
German Centre for Cardiovascular Research (DZHK), partner site Munich Heart Alliance, Munich, Germany.

Claudia M van Tiel (CM)

Department of Medical Biochemistry, Amsterdam Cardiovascular Sciences (ACS), Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, The Netherlands.

Tom T P Seijkens (TTP)

Department of Medical Biochemistry, Amsterdam Cardiovascular Sciences (ACS), Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, The Netherlands.

Pascal J H Kusters (PJH)

Department of Medical Biochemistry, Amsterdam Cardiovascular Sciences (ACS), Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, The Netherlands.

Ela Karshovka (E)

Institute for Cardiovascular Prevention (IPEK), Ludwig-Maximilians-Universität, Munich, Germany.

Koen H M Prange (KHM)

Department of Medical Biochemistry, Amsterdam Cardiovascular Sciences (ACS), Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, The Netherlands.

Yuting Wu (Y)

Institute for Cardiovascular Prevention (IPEK), Ludwig-Maximilians-Universität, Munich, Germany.

Sanne L N Brouns (SLN)

Department of Biochemistry, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht, The Netherlands.

Sigrid Unterlugauer (S)

Institute for Cardiovascular Prevention (IPEK), Ludwig-Maximilians-Universität, Munich, Germany.

Marijke J E Kuijpers (MJE)

Department of Biochemistry, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht, The Netherlands.

Myrthe E Reiche (ME)

Department of Medical Biochemistry, Amsterdam Cardiovascular Sciences (ACS), Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, The Netherlands.

Sabine Steffens (S)

Institute for Cardiovascular Prevention (IPEK), Ludwig-Maximilians-Universität, Munich, Germany.
German Centre for Cardiovascular Research (DZHK), partner site Munich Heart Alliance, Munich, Germany.

Andreas Edsfeldt (A)

Department of Clinical Sciences Malmö, Lund University, Clinical Research Center, Malmö, Sweden.
Department of Cardiology, Skåne University Hospital, Lund University, Malmö, Sweden.
Wallenberg Centre for Molecular Medicine, Lund University, Lund, Sweden.

Remco T A Megens (RTA)

Institute for Cardiovascular Prevention (IPEK), Ludwig-Maximilians-Universität, Munich, Germany.

Johan W M Heemskerk (JWM)

Department of Biochemistry, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht, The Netherlands.

Isabel Goncalves (I)

Department of Clinical Sciences Malmö, Lund University, Clinical Research Center, Malmö, Sweden.
Department of Cardiology, Skåne University Hospital, Lund University, Malmö, Sweden.

Christian Weber (C)

Institute for Cardiovascular Prevention (IPEK), Ludwig-Maximilians-Universität, Munich, Germany.
German Centre for Cardiovascular Research (DZHK), partner site Munich Heart Alliance, Munich, Germany.
Department of Biochemistry, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht, The Netherlands.
Munich Cluster for Systems Neurology (SyNergy), Munich, Germany.

Norbert Gerdes (N)

Institute for Cardiovascular Prevention (IPEK), Ludwig-Maximilians-Universität, Munich, Germany. Norbert.Gerdes@med.uni-duesseldorf.de.
Division of Cardiology, Pulmonology and Vascular Medicine, Medical Faculty, University Hospital Düsseldorf, Düsseldorf, Germany. Norbert.Gerdes@med.uni-duesseldorf.de.

Dorothee Atzler (D)

Institute for Cardiovascular Prevention (IPEK), Ludwig-Maximilians-Universität, Munich, Germany. dorothee.atzler@med.uni-muenchen.de.
German Centre for Cardiovascular Research (DZHK), partner site Munich Heart Alliance, Munich, Germany. dorothee.atzler@med.uni-muenchen.de.
Walther-Straub-Institute of Pharmacology and Toxicology, Ludwig-Maximilians-Universität, Munich, Germany. dorothee.atzler@med.uni-muenchen.de.

Esther Lutgens (E)

Institute for Cardiovascular Prevention (IPEK), Ludwig-Maximilians-Universität, Munich, Germany. Esther.Lutgens@med.uni-muenchen.de.
German Centre for Cardiovascular Research (DZHK), partner site Munich Heart Alliance, Munich, Germany. Esther.Lutgens@med.uni-muenchen.de.
Department of Medical Biochemistry, Amsterdam Cardiovascular Sciences (ACS), Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, The Netherlands. Esther.Lutgens@med.uni-muenchen.de.

Articles similaires

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female
Robotic Surgical Procedures Animals Humans Telemedicine Models, Animal

Odour generalisation and detection dog training.

Lyn Caldicott, Thomas W Pike, Helen E Zulch et al.
1.00
Animals Odorants Dogs Generalization, Psychological Smell
Animals TOR Serine-Threonine Kinases Colorectal Neoplasms Colitis Mice

Classifications MeSH