Brain Dynamics Underlying Cognitive Flexibility Across the Lifespan.
aging
central executive network
default mode network
executive function
salience network
Journal
Cerebral cortex (New York, N.Y. : 1991)
ISSN: 1460-2199
Titre abrégé: Cereb Cortex
Pays: United States
ID NLM: 9110718
Informations de publication
Date de publication:
01 10 2021
01 10 2021
Historique:
received:
17
02
2021
revised:
13
05
2021
accepted:
16
05
2021
pubmed:
20
6
2021
medline:
1
4
2022
entrez:
19
6
2021
Statut:
ppublish
Résumé
The neural mechanisms contributing to flexible cognition and behavior and how they change with development and aging are incompletely understood. The current study explored intrinsic brain dynamics across the lifespan using resting-state fMRI data (n = 601, 6-85 years) and examined the interactions between age and brain dynamics among three neurocognitive networks (midcingulo-insular network, M-CIN; medial frontoparietal network, M-FPN; and lateral frontoparietal network, L-FPN) in relation to behavioral measures of cognitive flexibility. Hierarchical multiple regression analysis revealed brain dynamics among a brain state characterized by co-activation of the L-FPN and M-FPN, and brain state transitions, moderated the relationship between quadratic effects of age and cognitive flexibility as measured by scores on the Delis-Kaplan Executive Function System (D-KEFS) test. Furthermore, simple slope analyses of significant interactions revealed children and older adults were more likely to exhibit brain dynamic patterns associated with poorer cognitive flexibility compared with younger adults. Our findings link changes in cognitive flexibility observed with age with the underlying brain dynamics supporting these changes. Preventative and intervention measures should prioritize targeting these networks with cognitive flexibility training to promote optimal outcomes across the lifespan.
Identifiants
pubmed: 34145442
pii: 6304413
doi: 10.1093/cercor/bhab156
pmc: PMC8491685
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
5263-5274Subventions
Organisme : University of Miami
Organisme : NIMH NIH HHS
ID : R01 MH107549
Pays : United States
Organisme : NARSAD Young Investigator Award
Organisme : Canadian Institute for Advanced Research
Organisme : NIMH NIH HHS
ID : R03 MH121668
Pays : United States
Informations de copyright
© The Author(s) 2021. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
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