Changes in ghrelin, substance P and vasoactive intestinal peptide levels in the gastroduodenal mucosa of patients with morbid obesity.
Gastroduodenal tissue
Ghrelin
Morbid obesity
Substance P
Vasoactive intestinal peptide
Journal
Neuropeptides
ISSN: 1532-2785
Titre abrégé: Neuropeptides
Pays: Netherlands
ID NLM: 8103156
Informations de publication
Date de publication:
Oct 2021
Oct 2021
Historique:
received:
02
01
2021
revised:
31
05
2021
accepted:
31
05
2021
pubmed:
20
6
2021
medline:
27
1
2022
entrez:
19
6
2021
Statut:
ppublish
Résumé
The aim of the study was to assess changes in levels of substance P (SP), vasoactive intestinal peptide (VIP) and ghrelin in the gastroduodenal mucosa of obese individuals, which has not been studied before. Forty-six patients with a body mass index (BMI) of >40 kg/m Antrum SP levels were higher in the obese group than in the control group. A significant number of obese patients had low VIP levels in the fundus and antrum. Intense ghrelin staining was observed in a limited number of cells in the mucosal area of the gastric fundus that was similar in the control and patient groups. In the antrum and duodenum, ghrelin staining was low in all the samples examined. Here, we found that SP levels are increased, while VIP levels are decreased in the antrum of morbidly obese individuals. Previous studies show that SP increases gastroduodenal motility, that VIP slows it down, and that the gastric emptying rate is higher in obese individuals, preventing negative feedback mechanisms upon food intake. Therefore, increases in SP and decreases in VIP levels in the antrum may contribute to obesity by accelerating gastric emptying.
Identifiants
pubmed: 34146741
pii: S0143-4179(21)00050-0
doi: 10.1016/j.npep.2021.102164
pii:
doi:
Substances chimiques
Ghrelin
0
Substance P
33507-63-0
Vasoactive Intestinal Peptide
37221-79-7
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
102164Informations de copyright
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