The role of sirtuin 1 on the induction of trained immunity.
Adaptive Immunity
Cells, Cultured
Cytokines
/ metabolism
Genotype
Humans
Immunity, Innate
Immunization
Immunologic Memory
Inflammation
/ immunology
Inflammation Mediators
/ metabolism
Leukocytes, Mononuclear
/ immunology
Mycobacterium bovis
/ immunology
Polymorphism, Single Nucleotide
Sirtuin 1
/ antagonists & inhibitors
beta-Glucans
/ immunology
Inflammation
Sirtuin 1
Trained immunity
Journal
Cellular immunology
ISSN: 1090-2163
Titre abrégé: Cell Immunol
Pays: Netherlands
ID NLM: 1246405
Informations de publication
Date de publication:
08 2021
08 2021
Historique:
received:
26
11
2020
revised:
31
05
2021
accepted:
05
06
2021
pubmed:
21
6
2021
medline:
23
11
2021
entrez:
20
6
2021
Statut:
ppublish
Résumé
Sirtuin 1 (SIRT1) has been described to modify immune responses by modulation of gene transcription. As transcriptional reprogramming is the molecular substrate of trained immunity, a de facto innate immune memory, we investigated the role of SIRT1 in the induction of trained immunity. We identified various SIRT1 genetic single nucleotide polymorphisms affecting innate and adaptive cytokine production of human peripheral blood mononuclear cells (PBMCs) in response to various stimuli on the one hand, and in vitro induction of trained immunity on the other hand. Furthermore, inhibition of SIRT1 upregulated pro-inflammatory innate cytokine production upon stimulation of PBMCs. However, inhibition of SIRT1 in vitro had no effect on cytokine responses upon induction of trained immunity, while activation of SIRT1 mildly modified trained immunity responses. In conclusion, SIRT1 modifies innate cytokine production by PBMCs in response to various microbes, but has only a secondary role for BCG and β-glucan-induced trained immunity responses.
Identifiants
pubmed: 34147841
pii: S0008-8749(21)00112-X
doi: 10.1016/j.cellimm.2021.104393
pii:
doi:
Substances chimiques
Cytokines
0
Inflammation Mediators
0
beta-Glucans
0
SIRT1 protein, human
EC 3.5.1.-
Sirtuin 1
EC 3.5.1.-
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
104393Informations de copyright
Copyright © 2021. Published by Elsevier Inc.