Inefficient Placental Virus Replication and Absence of Neonatal Cell-Specific Immunity Upon Sars-CoV-2 Infection During Pregnancy.
SARS-CoV
T cell response
human trial
prenatal infection
variants of concern
vertical transfer
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2021
2021
Historique:
received:
21
04
2021
accepted:
13
05
2021
entrez:
21
6
2021
pubmed:
22
6
2021
medline:
25
6
2021
Statut:
epublish
Résumé
Pregnant women have been carefully observed during the COVID-19 pandemic, as the pregnancy-specific immune adaptation is known to increase the risk for infections. Recent evidence indicates that even though most pregnant have a mild or asymptomatic course, a severe course of COVID-19 and a higher risk of progression to diseases have also been described, along with a heightened risk for pregnancy complications. Yet, vertical transmission of the virus is rare and the possibility of placental SARS-CoV-2 infection as a prerequisite for vertical transmission requires further studies. We here assessed the severity of COVID-19 and onset of neonatal infections in an observational study of women infected with SARS-CoV-2 during pregnancy. Our placental analyses showed a paucity of SARS-CoV-2 viral expression
Identifiants
pubmed: 34149740
doi: 10.3389/fimmu.2021.698578
pmc: PMC8211452
doi:
Types de publication
Journal Article
Observational Study
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
698578Informations de copyright
Copyright © 2021 Tallarek, Urbschat, Fonseca Brito, Stanelle-Bertram, Krasemann, Frascaroli, Thiele, Wieczorek, Felber, Lütgehetmann, Markert, Hecher, Brune, Stahl, Gabriel, Diemert and Arck.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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