Case report of a clinically indolent but morphologically high-grade cutaneous mast cell tumor in an adult: Atypical cutaneous mastocytoma or mast cell sarcoma?
adult
case reports
mast-cell sarcoma
mastocytoma
mastocytosis
Journal
Journal of cutaneous pathology
ISSN: 1600-0560
Titre abrégé: J Cutan Pathol
Pays: United States
ID NLM: 0425124
Informations de publication
Date de publication:
Nov 2021
Nov 2021
Historique:
revised:
03
05
2021
received:
27
02
2021
accepted:
15
05
2021
pubmed:
22
6
2021
medline:
9
2
2022
entrez:
21
6
2021
Statut:
ppublish
Résumé
We present a case of an adult male with a solitary mast cell tumor of the skin with unusual nuclear pleomorphism and mitotic activity. The tumor was excised, recurred within 2 years, was reexcised after 4 years and did not recur >6 years after diagnosis. The tumor showed progressive cytonuclear atypia and a high mitotic and proliferation rate by Ki67-staining from the onset. No KIT mutations were identified in the tumor and bone marrow. Serum tryptase levels and a bone marrow aspirate and trephine biopsy were normal. Although the histomorphology of the skin tumor was consistent with mast cell sarcoma, the clinical behavior without systemic progression argued against this diagnosis. The tumor was finally considered as atypical mastocytoma, borderline to mast cell sarcoma. Currently, the patient is in close follow-up and still in complete remission.
Identifiants
pubmed: 34152029
doi: 10.1111/cup.14088
pmc: PMC8638666
doi:
Types de publication
Case Reports
Langues
eng
Sous-ensembles de citation
IM
Pagination
1404-1409Subventions
Organisme : Austrian Science Fund (FWF)
ID : F4704-B20
Organisme : Austrian Science Fund (FWF)
ID : P32470-B
Informations de copyright
© 2021 The Authors. Journal of Cutaneous Pathology published by John Wiley & Sons Ltd.
Références
J Cutan Pathol. 2021 Nov;48(11):1404-1409
pubmed: 34152029
J Allergy Clin Immunol. 2016 Jan;137(1):35-45
pubmed: 26476479
Am J Surg Pathol. 2012 May;36(5):779-82
pubmed: 22498828
Am J Ophthalmol Case Rep. 2018 Jan 04;9:103-105
pubmed: 29468227
Haematologica. 2007 Dec;92(12):e126-9
pubmed: 18055976
Arch Dermatol. 2004 Oct;140(10):1275-80
pubmed: 15492195
Leuk Res. 2001 Jul;25(7):529-36
pubmed: 11377677
J Dermatol Surg Oncol. 1993 May;19(5):487-8
pubmed: 8496494
Blood. 2017 Mar 16;129(11):1420-1427
pubmed: 28031180
Indian J Dermatol Venereol Leprol. 2009 Jan-Feb;75(1):101
pubmed: 19180694
Indian J Dermatol Venereol Leprol. 1997 Sep-Oct;63(5):310-1
pubmed: 20944363
Indian J Dermatol Venereol Leprol. 2008 Jan-Feb;74(1):41-3
pubmed: 18187823
J Allergy Clin Immunol Pract. 2019 Jan;7(1):81-87
pubmed: 30416055
Leuk Res. 2001 Jul;25(7):603-25
pubmed: 11377686
Am J Dermatopathol. 2002 Dec;24(6):490-2
pubmed: 12454601
Arch Dermatol. 1961 Nov;84:806-15
pubmed: 14452118
J Cutan Pathol. 2012 Aug;39(8):773-6
pubmed: 22725660
J Am Acad Dermatol. 2011 Sep;65(3):683-684
pubmed: 21839341
Ophthalmic Plast Reconstr Surg. 2017 Jan/Feb;33(1):e10-e13
pubmed: 25603535
J Clin Pathol. 2011 Nov;64(11):1035-7
pubmed: 21778298
Mod Pathol. 1999 Jul;12(7):739-43
pubmed: 10430280
Dermatol Pract Concept. 2016 Jul 31;6(3):31-8
pubmed: 27648381
J Clin Oncol. 2013 Feb 20;31(6):e90-7
pubmed: 23129735
Arch Ophthalmol. 2001 Nov;119(11):1716-9
pubmed: 11709028
Am J Surg Pathol. 2003 Jul;27(7):1013-9
pubmed: 12826896
J Cutan Pathol. 2009 Nov;36(11):1215-20
pubmed: 19602070
J Clin Pathol. 1986 Jun;39(6):596-602
pubmed: 3088063
Am J Dermatopathol. 2019 Apr;41(4):296-299
pubmed: 30252695
Mod Pathol. 2013 Apr;26(4):533-43
pubmed: 23196796
Pathol Res Pract. 2012 Nov 15;208(11):683-6
pubmed: 22963840
Oncotarget. 2016 Oct 4;7(40):66299-66309
pubmed: 27602777
Ann Hematol. 2014 Jun;93(6):1067-9
pubmed: 24141335
J Cutan Pathol. 2018 Feb;45(2):176-179
pubmed: 29148588
Joint Bone Spine. 2003 Feb;70(1):64-6
pubmed: 12639621
Int J Hematol. 2011 Nov;94(5):491-4
pubmed: 22020400
Am J Dermatopathol. 2017 Apr;39(4):310-312
pubmed: 28328617
J Cutan Pathol. 2021 Jan;48(1):116-122
pubmed: 32896008