Sphingosine 1-phosphate and its receptors in ischemia.
Atherosclerosis
Ischemic stroke
Myocardial infarction
S1P
S1PRs
Journal
Clinica chimica acta; international journal of clinical chemistry
ISSN: 1873-3492
Titre abrégé: Clin Chim Acta
Pays: Netherlands
ID NLM: 1302422
Informations de publication
Date de publication:
Oct 2021
Oct 2021
Historique:
received:
19
02
2021
revised:
13
06
2021
accepted:
14
06
2021
pubmed:
22
6
2021
medline:
20
8
2021
entrez:
21
6
2021
Statut:
ppublish
Résumé
Sphingosine 1-phosphate (S1P), a metabolite of sphingolipids, is mainly derived from red blood cells (RBCs), platelets and endothelial cells (ECs). It plays important roles in regulating cell survival, vascular integrity and inflammatory responses through its receptors. S1P receptors (S1PRs), including 5 subtypes (S1PR1-5), are G protein-coupled receptors and have been proved to mediate various and complex roles of S1P in atherosclerosis, myocardial infarction (MI) and ischemic stroke by regulating endothelial function and inflammatory response as well as immune cell behavior. This review emphasizes the functions of S1PRs in atherosclerosis and ischemic diseases such as MI and ischemic stroke, enabling mechanistic studies and new S1PRs targeted therapies in atherosclerosis and ischemia in the future.
Identifiants
pubmed: 34153277
pii: S0009-8981(21)00221-7
doi: 10.1016/j.cca.2021.06.020
pii:
doi:
Substances chimiques
Lysophospholipids
0
sphingosine 1-phosphate
26993-30-6
Sphingosine
NGZ37HRE42
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
25-33Informations de copyright
Copyright © 2021 Elsevier B.V. All rights reserved.