Modularity and granularity across the language network-A primary progressive aphasia perspective.
Dementia
Grammar
Repetition
Semantics
Word comprehension
Journal
Cortex; a journal devoted to the study of the nervous system and behavior
ISSN: 1973-8102
Titre abrégé: Cortex
Pays: Italy
ID NLM: 0100725
Informations de publication
Date de publication:
08 2021
08 2021
Historique:
received:
21
12
2020
revised:
22
03
2021
accepted:
05
05
2021
pubmed:
22
6
2021
medline:
4
8
2021
entrez:
21
6
2021
Statut:
ppublish
Résumé
Tests of grammar, repetition and semantics were administered to 62 prospectively enrolled right-handed participants with primary progressive aphasia (PPA). Structural brain images were obtained at the time of testing. Regression analyses uncovered 3 clearly delineated non-overlapping left hemisphere clusters where cortical thinning (atrophy) was significantly correlated with impaired performance. A morphosyntactic cluster associated with the grammaticality of sentence construction was located predominantly within the middle and inferior frontal gyri; a phonolexical cluster associated with language repetition was located in the temporoparietal junction; a lexicosemantic cluster associated with object naming and single word comprehension was located within the middle and anterior parts of the temporal lobe and extended into insular, orbitofrontal, and mediotemporal cortices. Commonality analyses were undertaken to explore whether these three clusters were as modular as indicated by the regression analyses or whether some underlying functional granularity could be uncovered. Modularity was defined as the exclusive association of an anatomical cluster with a single type of language task whereas granularity was defined as the association of a single anatomical cluster with more than one type of language task. The commonality analyses revealed a predominantly modular organization with quantitatively minor instances of inter-cluster granularity. The results also reconfirmed previous work on PPA which had shown that Wernicke's area is not essential for word comprehension, that naming impairments can be based either on deficits of lexical retrieval or word comprehension, and that the essential substrates of word comprehension encompass much wider areas of the temporal lobe than the temporal pole. The anatomy of the language network has traditionally been explored through patients with focal cerebrovascular accidents and experiments based on functional activation. Investigations on PPA are showing that focal neurodegenerations can add new perspectives to existing models of the language network.
Identifiants
pubmed: 34153680
pii: S0010-9452(21)00189-1
doi: 10.1016/j.cortex.2021.05.002
pmc: PMC8319115
mid: NIHMS1708202
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
482-496Subventions
Organisme : NIDCD NIH HHS
ID : R01 DC008552
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG072977
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG013854
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG056258
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001422
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS075075
Pays : United States
Informations de copyright
Copyright © 2021 The Author(s). Published by Elsevier Ltd.. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest None by any of the authors.
Références
Nature. 1994 Nov 17;372(6503):260-3
pubmed: 7969469
Psychol Rev. 1989 Oct;96(4):523-68
pubmed: 2798649
J Neurosci. 2011 Mar 2;31(9):3344-50
pubmed: 21368046
Brain. 1991 Apr;114 ( Pt 2):743-54
pubmed: 2043946
Neurology. 1993 Nov;43(11):2412-4
pubmed: 8232972
Science. 2006 Nov 24;314(5803):1311-4
pubmed: 17124325
Proc Natl Acad Sci U S A. 2017 May 2;114(18):E3669-E3678
pubmed: 28416691
Curr Opin Neurobiol. 2014 Oct;28:136-41
pubmed: 25062474
Brain. 2001 Jan;124(Pt 1):83-95
pubmed: 11133789
J Neurolinguistics. 2011 Mar;24(2):183-201
pubmed: 22279249
Nat Rev Neurosci. 2008 Dec;9(12):920-33
pubmed: 19020511
Ann Neurol. 1985 Jun;17(6):549-57
pubmed: 4026225
Neuropsychologia. 2013 Aug;51(10):1814-22
pubmed: 23778263
Sci Am. 1972 Apr;226(4):76-83
pubmed: 5014017
Aphasiology. 2012;26(1):20-43
pubmed: 22199417
Neuroimage. 2002 Apr;15(4):870-8
pubmed: 11906227
Brain. 2010 Jul;133(Pt 7):2069-88
pubmed: 20542982
Curr Neurol Neurosci Rep. 2017 Aug;17(8):58
pubmed: 28656532
J Cogn Neurosci. 2015 Mar;27(3):464-73
pubmed: 25244113
J Neurosci. 2005 Jun 1;25(22):5397-403
pubmed: 15930389
Neuron. 2011 Oct 20;72(2):385-96
pubmed: 22017995
Cortex. 2015 Jul;68:100-10
pubmed: 25444577
Adv Exp Med Biol. 2021;1281:33-49
pubmed: 33433867
Brain. 1992 Dec;115 ( Pt 6):1753-68
pubmed: 1486459
J Neurosci. 2012 Apr 4;32(14):4848-55
pubmed: 22492040
Nature. 1988 Feb 18;331(6157):585-9
pubmed: 3277066
Curr Biol. 1994 Dec 1;4(12):1125-7
pubmed: 7704578
Cortex. 2019 Jul;116:4-44
pubmed: 30268324
J Neurophysiol. 2010 Aug;104(2):1177-94
pubmed: 20410363
Ann Neurol. 2017 Jun;81(6):759-768
pubmed: 28445916
Hum Brain Mapp. 2002 Aug;16(4):251-61
pubmed: 12112766
Cortex. 2019 Oct;119:497-510
pubmed: 31527011
Cereb Cortex. 2020 Mar 14;30(3):1481-1498
pubmed: 31670779
J Neurosci. 2010 Dec 15;30(50):16845-54
pubmed: 21159955
Brain. 2020 Oct 1;143(10):3121-3135
pubmed: 32940648
Cortex. 2008 Sep;44(8):953-61
pubmed: 18614162
Brain. 2013 Feb;136(Pt 2):601-18
pubmed: 23361063
Curr Opin Neurobiol. 1999 Apr;9(2):235-9
pubmed: 10322178
Hum Brain Mapp. 1999;8(4):272-84
pubmed: 10619420
Neuroimage. 1999 Jul;10(1):15-35
pubmed: 10385578
Cogn Behav Neurol. 2019 Mar;32(1):46-53
pubmed: 30896577
Neurology. 2019 Jan 15;92(3):e224-e233
pubmed: 30578374
Cereb Cortex. 2013 Jan;23(1):139-47
pubmed: 22275482
Ann Neurol. 1995 Apr;37(4):538-45
pubmed: 7717691
Neuron. 2016 Mar 16;89(6):1187-1193
pubmed: 26924439
Brain. 2009 Dec;132(Pt 12):3411-27
pubmed: 19942676
Neuron. 2017 Jul 19;95(2):457-471.e5
pubmed: 28728026
Cereb Cortex. 2005 May;15(5):616-27
pubmed: 15342435
Alzheimer Dis Assoc Disord. 2008 Oct-Dec;22(4):343-51
pubmed: 18580588
Neurology. 2015 Dec 15;85(24):2170-5
pubmed: 26567270
Neuroscience. 2019 Aug 10;413:219-229
pubmed: 31200104
J Neurosci. 2012 Aug 1;32(31):10649-61
pubmed: 22855814
IEEE Trans Med Imaging. 2007 Apr;26(4):518-29
pubmed: 17427739
Philos Trans R Soc Lond B Biol Sci. 2005 Apr 29;360(1456):815-36
pubmed: 15937014
J Neurosci. 2010 Aug 18;30(33):11057-61
pubmed: 20720112
Brain. 2013 Aug;136(Pt 8):2619-28
pubmed: 23820597
Science. 2019 Oct 4;366(6461):62-66
pubmed: 31604303
Neurology. 2011 Mar 15;76(11):1006-14
pubmed: 21325651
Brain. 2009 Sep;132(Pt 9):2553-65
pubmed: 19506067
Hum Brain Mapp. 2001 Aug;13(4):199-212
pubmed: 11410949
Neurology. 2020 Feb 11;94(6):e594-e606
pubmed: 31996450
Proc Natl Acad Sci U S A. 2000 Sep 26;97(20):11050-5
pubmed: 10984517
Exp Brain Res. 1989;77(3):451-75
pubmed: 2806441
Brain Lang. 2013 Nov;127(2):181-91
pubmed: 24404576
Ann N Y Acad Sci. 2016 Apr;1369(1):132-53
pubmed: 27096882
Brain Lang. 2020 Jan;200:104712
pubmed: 31704517
J Speech Lang Hear Res. 2018 Feb 15;61(2):373-385
pubmed: 29411008
J Neurosci. 2013 Mar 27;33(13):5439-53
pubmed: 23536060
Science. 2009 Oct 16;326(5951):445-9
pubmed: 19833971
Brain Lang. 2004 May;89(2):329-36
pubmed: 15068915
Neuron. 2006 Jun 15;50(6):963-74
pubmed: 16772176
Neurology. 2014 Sep 23;83(13):1184-91
pubmed: 25165386
Ann Neurol. 2005 Jan;57(1):8-16
pubmed: 15597383
Brain Lang. 2012 Mar;120(3):237-50
pubmed: 22244508
Brain. 1998 Jun;121 ( Pt 6):1013-52
pubmed: 9648540
Brain Lang. 2003 Jun;85(3):402-8
pubmed: 12744952
Brain Lang. 2012 Feb;120(2):163-73
pubmed: 20472279
Physiol Rev. 2011 Oct;91(4):1357-92
pubmed: 22013214
Cereb Cortex. 2001 Mar;11(3):223-37
pubmed: 11230094
Am J Alzheimers Dis Other Demen. 2009 Oct-Nov;24(5):408-16
pubmed: 19700669
Cortex. 2019 Dec;121:468-480
pubmed: 31530376
Cortex. 2016 Apr;77:164-166
pubmed: 26387007
Alzheimer Dis Assoc Disord. 2017 Apr-Jun;31(2):101-106
pubmed: 28288010
Neuroimage. 2005 Jul 15;26(4):975-85
pubmed: 15893473
Proc Natl Acad Sci U S A. 2008 Nov 18;105(46):18035-40
pubmed: 19004769
Cognition. 2004 May-Jun;92(1-2):145-77
pubmed: 15037129
Brain. 2008 Aug;131(Pt 8):2013-27
pubmed: 18669510
Brain. 2015 Aug;138(Pt 8):2423-37
pubmed: 26112340
J Neurosci. 1994 Apr;14(4):1908-19
pubmed: 8158246
Front Psychol. 2013 Jul 12;4:416
pubmed: 23874313
Brain. 2013 Feb;136(Pt 2):619-29
pubmed: 23378217
Brain. 2012 May;135(Pt 5):1537-53
pubmed: 22525158
Ann Neurol. 2008 Oct;64(4):367-78
pubmed: 18991346
Int J Mol Sci. 2020 Oct 11;21(20):
pubmed: 33050556
Brain. 1991 Aug;114 ( Pt 4):1803-17
pubmed: 1884179
Trends Cogn Sci. 2020 Apr;24(4):270-284
pubmed: 32160565
Neuron. 1999 Oct;24(2):427-32
pubmed: 10571235
Ann Neurol. 2004 Mar;55(3):335-46
pubmed: 14991811
Nat Rev Neurosci. 2007 May;8(5):393-402
pubmed: 17431404
J Neurosci. 2009 Dec 16;29(50):15762-9
pubmed: 20016092
Neuroimage. 2012 Feb 15;59(4):3514-21
pubmed: 22100771
Ann Neurol. 2019 May;85(5):630-643
pubmed: 30851133
Neuroimage. 2011 Apr 15;55(4):1836-46
pubmed: 21168512