Effect of ivabradine on heart rate, functional capacity and pulmonary artery pressure in patients of COPD with cor pulmonale.
COPD
Cor pulmonale
Ivabradine
Journal
Indian heart journal
ISSN: 2213-3763
Titre abrégé: Indian Heart J
Pays: India
ID NLM: 0374675
Informations de publication
Date de publication:
Historique:
received:
16
09
2020
revised:
14
01
2021
accepted:
23
03
2021
entrez:
22
6
2021
pubmed:
23
6
2021
medline:
21
10
2021
Statut:
ppublish
Résumé
We studied the effects of heart rate reduction by ivabradine to the ongoing therapy in patients with chronic obstructive pulmonary disease (COPD) and cor pulmonale.100 patients of COPD with cor pulmonale with sinus heart rate ≥ 90 bpm were randomly assigned to either ivabradine 5 mg twice daily (50 patients) or placebo (50 patients) alongwith standard therapy. Assessment was done at baseline and after 6 months which included 6 min walk test (6MWT), dyspnea scoring by modified borg scale, Lung function test by forced expiratory volume in 1 s (FEV1) and pulmonary artery systolic pressure (PASP) by echocardiogram. The drug group showed a significant reduction in heart rate from 95.1 ± 8.2 bpm to 71.1 ± 6.2 bpm (p < 0.001). This group also showed significant improvement in 6-min walk distance and dyspnea on modified Borg scale (p < 0.001) at 6 months follow up. However no significant difference was found between both groups regarding PASP or FEV1 at 6 months.
Identifiants
pubmed: 34154759
pii: S0019-4832(21)00067-5
doi: 10.1016/j.ihj.2021.03.009
pmc: PMC8322798
pii:
doi:
Substances chimiques
Ivabradine
3H48L0LPZQ
Types de publication
Journal Article
Randomized Controlled Trial
Langues
eng
Sous-ensembles de citation
IM
Pagination
369-371Informations de copyright
Copyright © 2021 Cardiological Society of India. Published by Elsevier B.V. All rights reserved.
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