Uncialamycin-based antibody-drug conjugates: Unique enediyne ADCs exhibiting bystander killing effect.
antibody–drug conjugates
bystander killing effect
enediyne payloads
Journal
Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876
Informations de publication
Date de publication:
22 06 2021
22 06 2021
Historique:
entrez:
22
6
2021
pubmed:
23
6
2021
medline:
15
12
2021
Statut:
ppublish
Résumé
Antibody-drug conjugates (ADCs) have emerged as valuable targeted anticancer therapeutics with at least 11 approved therapies and over 80 advancing through clinical trials. Enediyne DNA-damaging payloads represented by the flagship of this family of antitumor agents,
Identifiants
pubmed: 34155147
pii: 2107042118
doi: 10.1073/pnas.2107042118
pmc: PMC8237573
pii:
doi:
Substances chimiques
Anthraquinones
0
Immunoconjugates
0
uncialamycin
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Déclaration de conflit d'intérêts
The authors declare no competing interest.
Références
Chem Soc Rev. 2019 Aug 12;48(16):4361-4374
pubmed: 31294429
Bioconjug Chem. 2002 Jan-Feb;13(1):47-58
pubmed: 11792178
Angew Chem Int Ed Engl. 2007;46(25):4704-7
pubmed: 17497617
Mol Cancer Ther. 2017 Jan;16(1):116-123
pubmed: 28062707
Expert Rev Clin Pharmacol. 2018 Jun;11(6):549-559
pubmed: 29787320
Bioconjug Chem. 2015 Apr 15;26(4):650-9
pubmed: 25643134
Cancer Res. 1998 Jul 15;58(14):2925-8
pubmed: 9679947
Blood. 2014 May 15;123(20):3128-38
pubmed: 24569262
Cancer Res. 1993 Jul 15;53(14):3336-42
pubmed: 8324745
Bioconjug Chem. 2018 Apr 18;29(4):1155-1167
pubmed: 29481745
J Am Chem Soc. 2016 Jul 6;138(26):8235-46
pubmed: 27266267
Blood. 2009 Sep 24;114(13):2721-9
pubmed: 19633198
J Med Chem. 2014 Aug 28;57(16):6949-64
pubmed: 24967516
Blood. 2003 Aug 15;102(4):1458-65
pubmed: 12714494
Clin Cancer Res. 2016 Oct 15;22(20):5097-5108
pubmed: 27026201
J Pharmacokinet Pharmacodyn. 2016 Dec;43(6):567-582
pubmed: 27670282
Clin Cancer Res. 2011 May 15;17(10):3157-69
pubmed: 21372224
Antib Ther. 2021 Jan;4(1):1-15
pubmed: 33554043
BMC Cancer. 2019 Mar 4;19(1):194
pubmed: 30832603
Cancer Immunol Immunother. 2007 Jul;56(7):1107-17
pubmed: 17160682
Blood Adv. 2019 Jan 8;3(1):96-104
pubmed: 30622147
J Nat Prod. 2021 Mar 26;84(3):917-931
pubmed: 33635651
Drugs. 2017 Sep;77(14):1603-1610
pubmed: 28819740
Haematologica. 2019 Jan;104(1):7-9
pubmed: 30598494
Cancer Res. 2016 May 15;76(10):3003-13
pubmed: 27013195
Clin Cancer Res. 2009 Feb 1;15(3):832-9
pubmed: 19188153
J Clin Pharmacol. 2004 Aug;44(8):873-80
pubmed: 15286091
Blood. 2018 Mar 8;131(10):1094-1105
pubmed: 29298756
Blood. 2004 Mar 1;103(5):1807-14
pubmed: 14615373
Angew Chem Int Ed Engl. 2008;47(1):185-9
pubmed: 18058881
Br J Cancer. 2017 Dec 5;117(12):1736-1742
pubmed: 29065110
Org Lett. 2005 Nov 10;7(23):5233-6
pubmed: 16268546