KL-VS heterozygosity is associated with lower amyloid-dependent tau accumulation and memory impairment in Alzheimer's disease.
Aged
Alzheimer Disease
/ genetics
Amyloid beta-Peptides
/ metabolism
Apolipoproteins E
/ genetics
Brain
/ diagnostic imaging
Female
Gene Expression
Glucuronidase
/ genetics
Heterozygote
Humans
Klotho Proteins
Male
Memory Disorders
/ genetics
Middle Aged
Polymorphism, Single Nucleotide
Positron-Emission Tomography
/ methods
Protein Binding
tau Proteins
/ metabolism
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
22 06 2021
22 06 2021
Historique:
received:
10
08
2020
accepted:
12
05
2021
entrez:
23
6
2021
pubmed:
24
6
2021
medline:
20
7
2021
Statut:
epublish
Résumé
Klotho-VS heterozygosity (KL-VS
Identifiants
pubmed: 34158479
doi: 10.1038/s41467-021-23755-z
pii: 10.1038/s41467-021-23755-z
pmc: PMC8219708
doi:
Substances chimiques
Amyloid beta-Peptides
0
Apolipoproteins E
0
tau Proteins
0
Glucuronidase
EC 3.2.1.31
Klotho Proteins
EC 3.2.1.31
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
3825Subventions
Organisme : NIA NIH HHS
ID : P30 AG066462
Pays : United States
Organisme : NIA NIH HHS
ID : U01 AG024904
Pays : United States
Organisme : CIHR
Pays : Canada
Investigateurs
Michael Weiner
(M)
Paul Aisen
(P)
Ronald Petersen
(R)
Clifford R Jack
(CR)
William Jagust
(W)
John Q Trojanowki
(JQ)
Arthur W Toga
(AW)
Laurel Beckett
(L)
Robert C Green
(RC)
Andrew J Saykin
(AJ)
John Morris
(J)
Leslie M Shaw
(LM)
Enchi Liu
(E)
Tom Montine
(T)
Ronald G Thomas
(RG)
Michael Donohue
(M)
Sarah Walter
(S)
Devon Gessert
(D)
Tamie Sather
(T)
Gus Jiminez
(G)
Danielle Harvey
(D)
Matthew Bernstein
(M)
Nick Fox
(N)
Paul Thompson
(P)
Norbert Schuff
(N)
Charles DeCArli
(C)
Bret Borowski
(B)
Jeff Gunter
(J)
Matt Senjem
(M)
Prashanthi Vemuri
(P)
David Jones
(D)
Kejal Kantarci
(K)
Chad Ward
(C)
Robert A Koeppe
(RA)
Norm Foster
(N)
Eric M Reiman
(EM)
Kewei Chen
(K)
Chet Mathis
(C)
Susan Landau
(S)
Nigel J Cairns
(NJ)
Erin Householder
(E)
Lisa Taylor Reinwald
(LT)
Virginia Lee
(V)
Magdalena Korecka
(M)
Michal Figurski
(M)
Karen Crawford
(K)
Scott Neu
(S)
Tatiana M Foroud
(TM)
Steven Potkin
(S)
Li Shen
(L)
Faber Kelley
(F)
Sungeun Kim
(S)
Kwangsik Nho
(K)
Zaven Kachaturian
(Z)
Richard Frank
(R)
Peter J Snyder
(PJ)
Susan Molchan
(S)
Jeffrey Kaye
(J)
Joseph Quinn
(J)
Betty Lind
(B)
Raina Carter
(R)
Sara Dolen
(S)
Lon S Schneider
(LS)
Sonia Pawluczyk
(S)
Mauricio Beccera
(M)
Liberty Teodoro
(L)
Bryan M Spann
(BM)
James Brewer
(J)
Helen Vanderswag
(H)
Adam Fleisher
(A)
Judith L Heidebrink
(JL)
Joanne L Lord
(JL)
Sara S Mason
(SS)
Colleen S Albers
(CS)
David Knopman
(D)
Kris Johnson
(K)
Rachelle S Doody
(RS)
Javier Villanueva Meyer
(JV)
Munir Chowdhury
(M)
Susan Rountree
(S)
Mimi Dang
(M)
Yaakov Stern
(Y)
Lawrence S Honig
(LS)
Karen L Bell
(KL)
Beau Ances
(B)
John C Morris
(JC)
Maria Carroll
(M)
Sue Leon
(S)
Mark A Mintun
(MA)
Stacy Schneider
(S)
Angela OliverNG
(A)
Randall Griffith
(R)
David Clark
(D)
David Geldmacher
(D)
John Brockington
(J)
Erik Roberson
(E)
Hillel Grossman
(H)
Effie Mitsis
(E)
Leyla deToledo-Morrell
(L)
Raj C Shah
(RC)
Ranjan Duara
(R)
Daniel Varon
(D)
Maria T Greig
(MT)
Peggy Roberts
(P)
Marilyn Albert
(M)
Chiadi Onyike
(C)
Daniel D'Agostino
(D)
Stephanie Kielb
(S)
James E Galvin
(JE)
Dana M Pogorelec
(DM)
Brittany Cerbone
(B)
Christina A Michel
(CA)
Henry Rusinek
(H)
Mony J de Leon
(MJ)
Lidia Glodzik
(L)
Susan De Santi
(S)
P Murali Doraiswamy
(PM)
Jeffrey R Petrella
(JR)
Terence Z Wong
(TZ)
Steven E Arnold
(SE)
Jason H Karlawish
(JH)
David Wolk
(D)
Charles D Smith
(CD)
Greg Jicha
(G)
Peter Hardy
(P)
Partha Sinha
(P)
Elizabeth Oates
(E)
Gary Conrad
(G)
Oscar L Lopez
(OL)
MaryAnn Oakley
(M)
Donna M Simpson
(DM)
Anton P Porsteinsson
(AP)
Bonnie S Goldstein
(BS)
Kim Martin
(K)
Kelly M Makino
(KM)
M Saleem Ismail
(MS)
Connie Brand
(C)
Ruth A Mulnard
(RA)
Gaby Thai
(G)
Catherine Mc Adams Ortiz
(C)
Kyle Womack
(K)
Dana Mathews
(D)
Mary Quiceno
(M)
Ramon Diaz Arrastia
(RD)
Richard King
(R)
Myron Weiner
(M)
Kristen Martin Cook
(KM)
Michael DeVous
(M)
Allan I Levey
(AI)
James J Lah
(JJ)
Janet S Cellar
(JS)
Jeffrey M Burns
(JM)
Heather S Anderson
(HS)
Russell H Swerdlow
(RH)
Liana Apostolova
(L)
Kathleen Tingus
(K)
Ellen Woo
(E)
Daniel H S Silverman
(DHS)
Po H Lu
(PH)
George Bartzokis
(G)
Neill R Graff Radford
(NRG)
Francine ParfittH
(F)
Tracy Kendall
(T)
Heather Johnson
(H)
Martin R Farlow
(MR)
Ann Marie Hake
(AM)
Brandy R Matthews
(BR)
Scott Herring
(S)
Cynthia Hunt
(C)
Christopher H van Dyck
(CH)
Richard E Carson
(RE)
Martha G MacAvoy
(MG)
Howard Chertkow
(H)
Howard Bergman
(H)
Chris Hosein
(C)
Sandra Black
(S)
Bojana Stefanovic
(B)
Curtis Caldwell
(C)
Ging Yuek Robin Hsiung
(GYR)
Howard Feldman
(H)
Benita Mudge
(B)
Michele Assaly Past
(MA)
Andrew Kertesz
(A)
John Rogers
(J)
Dick Trost
(D)
Charles Bernick
(C)
Donna Munic
(D)
Diana Kerwin
(D)
Marek Marsel Mesulam
(MM)
Kristine Lipowski
(K)
Chuang Kuo Wu
(CK)
Nancy Johnson
(N)
Carl Sadowsky
(C)
Walter Martinez
(W)
Teresa Villena
(T)
Raymond Scott Turner
(RS)
Kathleen Johnson
(K)
Brigid Reynolds
(B)
Reisa A Sperling
(RA)
Keith A Johnson
(KA)
Gad Marshall
(G)
Meghan Frey
(M)
Jerome Yesavage
(J)
Joy L Taylor
(JL)
Barton Lane
(B)
Allyson Rosen
(A)
Jared Tinklenberg
(J)
Marwan N Sabbagh
(MN)
Christine M Belden
(CM)
Sandra A Jacobson
(SA)
Sherye A Sirrel
(SA)
Neil Kowall
(N)
Ronald Killiany
(R)
Andrew E Budson
(AE)
Alexander Norbash
(A)
Patricia Lynn Johnson
(PL)
Thomas O Obisesan
(TO)
Saba Wolday
(S)
Joanne Allard
(J)
Alan Lerner
(A)
Paula Ogrocki
(P)
Leon Hudson
(L)
Evan Fletcher
(E)
Owen Carmichael
(O)
John Olichney
(J)
Charles DeCarli
(C)
Smita Kittur
(S)
Michael Borrie
(M)
T Y Lee
(TY)
Rob Bartha
(R)
Sterling Johnson
(S)
Sanjay Asthana
(S)
Cynthia M Carlsson
(CM)
Steven G Potkin
(SG)
Adrian Preda
(A)
Dana Nguyen
(D)
Pierre Tariot
(P)
Stephanie Reeder
(S)
Vernice Bates
(V)
Horacio Capote
(H)
Michelle Rainka
(M)
Douglas W Scharre
(DW)
Maria Kataki
(M)
Anahita Adeli
(A)
Earl A Zimmerman
(EA)
Dzintra Celmins
(D)
Alice D Brown
(AD)
Godfrey D Pearlson
(GD)
Karen Blank
(K)
Karen Anderson
(K)
Robert B Santulli
(RB)
Tamar J Kitzmiller
(TJ)
Eben S Schwartz
(ES)
Kaycee M SinkS
(KM)
Jeff D Williamson
(JD)
Pradeep Garg
(P)
Franklin Watkins
(F)
Brian R Ott
(BR)
Henry Querfurth
(H)
Geoffrey Tremont
(G)
Stephen Salloway
(S)
Paul Malloy
(P)
Stephen Correia
(S)
Howard J Rosen
(HJ)
Bruce L Miller
(BL)
Jacobo Mintzer
(J)
Kenneth Spicer
(K)
David Bachman
(D)
Elizabether Finger
(E)
Stephen Pasternak
(S)
Irina Rachinsky
(I)
Dick Drost
(D)
Nunzio Pomara
(N)
Raymundo Hernando
(R)
Antero Sarrael
(A)
Susan K Schultz
(SK)
Laura L Boles Ponto
(LLB)
Hyungsub Shim
(H)
Karen Elizabeth Smith
(KE)
Norman Relkin
(N)
Gloria Chaing
(G)
Lisa Raudin
(L)
Amanda Smith
(A)
Kristin Fargher
(K)
Balebail Ashok Raj
(BA)
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