Polygenic Risk Scores have high diagnostic capacity in ankylosing spondylitis.
Adult
Asian People
Back Pain
/ diagnosis
C-Reactive Protein
/ metabolism
Case-Control Studies
Chronic Pain
/ diagnosis
Female
HLA-B27 Antigen
/ genetics
Humans
Magnetic Resonance Imaging
Male
Multifactorial Inheritance
Reproducibility of Results
Risk Factors
Sacroiliac Joint
/ diagnostic imaging
Spondylitis, Ankylosing
/ diagnosis
White People
ankylosing
genetic
low back pain
magnetic resonance imaging
polymorphism
spondylitis
Journal
Annals of the rheumatic diseases
ISSN: 1468-2060
Titre abrégé: Ann Rheum Dis
Pays: England
ID NLM: 0372355
Informations de publication
Date de publication:
09 2021
09 2021
Historique:
received:
04
11
2020
revised:
23
03
2021
accepted:
29
03
2021
pubmed:
24
6
2021
medline:
21
9
2021
entrez:
23
6
2021
Statut:
ppublish
Résumé
We sought to test the hypothesis that Polygenic Risk Scores (PRSs) have strong capacity to discriminate cases of ankylosing spondylitis (AS) from healthy controls and individuals in the community with chronic back pain. PRSs were developed and validated in individuals of European and East Asian ethnicity, using data from genome-wide association studies in 15 585 AS cases and 20 452 controls. The discriminatory values of PRSs in these populations were compared with other widely used diagnostic tests, including C-reactive protein (CRP), In people of European descent, PRS had high discriminatory capacity with area under the curve (AUC) in receiver operator characteristic analysis of 0.924. This was significantly better than for PRS have higher discriminatory capacity for AS than CRP, sacroiliac MRI or
Identifiants
pubmed: 34161253
pii: annrheumdis-2020-219446
doi: 10.1136/annrheumdis-2020-219446
pmc: PMC8364478
mid: NIHMS1698337
doi:
Substances chimiques
HLA-B27 Antigen
0
C-Reactive Protein
9007-41-4
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1168-1174Subventions
Organisme : Arthritis Research UK
ID : 19536
Pays : United Kingdom
Organisme : Intramural NIH HHS
ID : Z99 AR999999
Pays : United States
Organisme : Wellcome Trust
ID : 076113
Pays : United Kingdom
Organisme : NIAMS NIH HHS
ID : R01 AR046208
Pays : United States
Organisme : NCRR NIH HHS
ID : M01 RR000425
Pays : United States
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : Arthritis Research UK
ID : 18797
Pays : United Kingdom
Investigateurs
Jian Yin
(J)
Lei Jiang
(L)
Lin Zhou
(L)
Ting Li
(T)
Qingwen Wang
(Q)
Tianwang Li
(T)
Guanmin Gao
(G)
Shengqian Xu
(S)
Weiguo Xiao
(W)
Hui Shen
(H)
Jingguo Zhou
(J)
Yuquan You
(Y)
Dongbao Zhao
(D)
Qing Cai
(Q)
Shengming Dai
(S)
Lan He
(L)
Ping Zhu
(P)
Zhenyu Jiang
(Z)
Jian Xu
(J)
Huaxiang Wu
(H)
Lie Dai
(L)
Yang Li
(Y)
Feng Ding
(F)
Xiaochun Zhu
(X)
Chongyang Liu
(C)
Dongyi He
(D)
Liyun Zhang
(L)
Zhijun Li
(Z)
Futao Zhao
(F)
Hanshi Xu
(H)
Niansong Wang
(N)
Youlian Wang
(Y)
Lindi Jiang
(L)
Yu Zhang
(Y)
Jinwei Chen
(J)
Fang Cheng
(F)
Zhiyi Zhang
(Z)
Yifang Mei
(Y)
Liangjing Lv
(L)
Lingli Dong
(L)
Jing Yang
(J)
Yinong Li
(Y)
Xiaodong Wang
(X)
Xiaofeng Li
(X)
Hongsheng Sun
(H)
Xianming Long
(X)
Xiao Zhang
(X)
Qinghong Yu
(Q)
Xiaodan Kong
(X)
Yi Zheng
(Y)
Miaojia Zhang
(M)
Yi Tao
(Y)
Yisha Li
(Y)
Xinwang Duan
(X)
Qianghua Wei
(Q)
Xiaofei Wang
(X)
Jie Han
(J)
Rong Mu
(R)
Yiping Lin
(Y)
Jian Zhu
(J)
Xiaoyuan Chen
(X)
Commentaires et corrections
Type : ErratumIn
Informations de copyright
© Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.
Déclaration de conflit d'intérêts
Competing interests: None declared.
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