Contribution of Extrahepatic Aldehyde Oxidase Activity to Human Clearance.

Aldehyde Oxidase / metabolism Aldehydes / metabolism Blood Vessels / enzymology Correlation of Data Enzyme Assays / methods Heterocyclic Compounds / metabolism Humans Intestines / enzymology Kidney / enzymology Liver / enzymology Lung / enzymology Metabolic Clearance Rate Tissue Distribution / physiology

Journal

Drug metabolism and disposition: the biological fate of chemicals
ISSN: 1521-009X
Titre abrégé: Drug Metab Dispos
Pays: United States
ID NLM: 9421550

Informations de publication

Date de publication:
09 2021
Historique:
received: 14 11 2020
accepted: 10 06 2021
pubmed: 25 6 2021
medline: 25 3 2022
entrez: 24 6 2021
Statut: ppublish

Résumé

Aldehyde oxidase (AOX) is a soluble, cytosolic enzyme that metabolizes various

Identifiants

DOI: 10.1124/dmd.120.000313 PMID: 34162687
pubmed: 34162687
pii: dmd.120.000313
doi: 10.1124/dmd.120.000313
doi:

Substances chimiques

Aldehydes 0
Heterocyclic Compounds 0
Aldehyde Oxidase EC 1.2.3.1

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

743-749

Informations de copyright

Copyright © 2021 by The Author(s).

Auteurs

Kirk D Kozminski (KD)

Takeda Pharmaceuticals Limited, San Diego, California (K.D.K., J.S., M.A.Z.); and BioIVT, Baltimore, Maryland (S.H.) kirk.kozminski@takeda.com.

Jangir Selimkhanov (J)

Takeda Pharmaceuticals Limited, San Diego, California (K.D.K., J.S., M.A.Z.); and BioIVT, Baltimore, Maryland (S.H.).

Scott Heyward (S)

Takeda Pharmaceuticals Limited, San Diego, California (K.D.K., J.S., M.A.Z.); and BioIVT, Baltimore, Maryland (S.H.).

Michael A Zientek (MA)

Takeda Pharmaceuticals Limited, San Diego, California (K.D.K., J.S., M.A.Z.); and BioIVT, Baltimore, Maryland (S.H.).

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Classifications MeSH

questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Oxidoreductases › Oxidoreductases acting on aldehyde or oxo group donors › Aldehyde oxidoreductases › Aldehyde oxidase › Contribution of Extrahepatic Aldehyde Oxidase...
questionsmedicales.fr › Composés chimiques organiques › Aldéhydes › Contribution of Extrahepatic Aldehyde Oxidase...
questionsmedicales.fr › Système cardiovasculaire › Vaisseaux sanguins › Contribution of Extrahepatic Aldehyde Oxidase...
questionsmedicales.fr › Disciplines des sciences naturelles › Mathématiques › Corrélation de données › Contribution of Extrahepatic Aldehyde Oxidase...
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Dosages enzymatiques › Contribution of Extrahepatic Aldehyde Oxidase...
questionsmedicales.fr › Composés hétérocycliques › Contribution of Extrahepatic Aldehyde Oxidase...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Contribution of Extrahepatic Aldehyde Oxidase...
questionsmedicales.fr › Système digestif › Tube digestif › Intestins › Contribution of Extrahepatic Aldehyde Oxidase...
questionsmedicales.fr › Appareil urogénital › Voies urinaires › Rein › Contribution of Extrahepatic Aldehyde Oxidase...
questionsmedicales.fr › Système digestif › Foie › Contribution of Extrahepatic Aldehyde Oxidase...
questionsmedicales.fr › Appareil respiratoire › Poumon › Contribution of Extrahepatic Aldehyde Oxidase...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Pharmacocinétique › Taux de clairance métabolique › Contribution of Extrahepatic Aldehyde Oxidase...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Pharmacocinétique › Distribution tissulaire › Contribution of Extrahepatic Aldehyde Oxidase...